Eschenmoser's salt | 36627-00-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Eschenmoser's salt
• 英文别名: Eschenmoser salt；N,N-dimethylaminomethyl iodide；iodomethyl-dimethyl-amine；Jodmethyl-dimethyl-amin；N-methyl-N-methylenemethanaminium iodide；N,N-dimethylmethyleneimmonium iodide；Dimethyl-methylen-ammonium-jodid；1-Iodo-N,N-dimethylmethanamine
• CAS: 36627-00-6
• 化学式: C₃H₈IN
• 分子量: 185.008
• InChiKey: VWCCXXIHYWIBTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  5
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

安全信息

• 海关编码：
  2921199090

反应信息

• 作为反应物：
  描述：

  丁香酚 、 Eschenmoser's salt 在 resin-NMe₃⁽¹⁺⁾*NaCO₃^(1-) 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 以90%的产率得到6-dimethylaminomethyl-2-methoxy-4-allylphenol
  参考文献：
  名称：

  Synthesis of the β₂ Agonist (R)-Salmeterol Using a Sequence of Supported Reagents and Scavenging Agents

  摘要：

  graphicThe enantioselective synthesis of (R)-salmeterol has been achieved by using a sequence of supported reagents and sequestering agents. The saligenin core was installed by a regiospecific alkylation and a chiral auxiliary approach was employed to introduce the desired stereochemistry via a diastereoselective reduction.

  DOI：

  10.1021/ol020128g
• 作为产物：
  描述：

  四甲基甲烷二胺 在 氢碘酸 、 N,N-二甲基甲酰胺 作用下， 生成 Eschenmoser's salt 、 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Boehme et al., Chemische Berichte, 1958, vol. 91, p. 340,344

  摘要：

  DOI：

文献信息

• Novel inhibitors of chymase
  申请人：Hawkins J. Michael

  公开号：US20050176769A1

  公开（公告）日：2005-08-11

  The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.

  本发明涉及一种化合物，其化学式为(I)，以及制备这些化合物的方法、组合物、中间体和衍生物，以及治疗炎症和丝氨酸蛋白酶介导的疾病的方法。
• Unified total synthesis of (+)-chinensiolide B and (+)-8-epigrosheimin
  作者：Saumen Hajra、Susit Acharyya、Abhisek Mandal、Ramkrishna Maity

  DOI：10.1039/c7ob01217a

  日期：——

  An expedient synthetic approach has been developed for the unified total synthesis of (+)-chinensiolide B and (+)-8-epigrosheimin. The point of divergence was provided by the lactone aldehyde 6, in which four contiguous stereocenters were achieved by stereocontrolled Evans syn-aldol reaction of R-carvone derived enantiopure aldehyde and chiral N-succinyl-oxazolidinone. The lactone aldehyde 6 was synthesized

  已经开发了一种方便的合成方法，用于统一合成（+）-chinensiolide B和（+）-8-epigrosheimin。分歧点是由内酯醛6提供的，其中通过R-香芹酮衍生的对映纯醛和手性N-琥珀酰-恶唑烷酮的立体控制Evans syn-aldol反应获得了四个连续的立体中心。分三步以数克的量合成内酯醛6。高度优化的化学和立体选择反应以及官能团的相互转化使我们能够从6位组装（+）-chinensiolide B amd（+）-8-epigrosheimin。
• Catalyst system
  申请人：Eastham Graham

  公开号：US20060252935A1

  公开（公告）日：2006-11-09

  A catalyst suitable for carbonylating ethylenically unsaturated compounds comprising a Group VIIIB metal or compound thereof and a metallocene.

  一种适用于酰化乙烯基不饱和化合物的催化剂，包括VIIIB族金属或其化合物和金属茂配合物。
• Catalyst System
  申请人：Eastham Graham

  公开号：US20070282124A1

  公开（公告）日：2007-12-06

  The present invention provides a catalyst system capable of catalysing the carbonylation of an ethylenically unsaturated compound, which system is obtainable by combining: a) a metal of Group VIB or Group VIIIB or a compound thereof, b) a bidentate phosphine, arsine or stibine ligand, and c) an acid, wherein said ligand is present in at least a 2:1 molar excess compared to said metal or said metal in said metal compound, and that said acid is present in at least a 2:1 molar excess compared to said ligand, a process for the carbonylation of an ethylenically unsaturated compound, a reaction medium, and use of the system.

  本发明提供了一种催化剂系统，能够催化含有乙烯基不饱和化合物的羰基化反应，该系统可通过以下步骤获得：a) 一种第VIB或第VIIIB族金属或其化合物，b) 一种双齿膦、砷或锑配体，c) 一种酸。其中，所述配体的摩尔量至少比所述金属或所述金属化合物中的金属高2:1，所述酸的摩尔量至少比所述配体高2:1。本发明还提供了一种含有乙烯基不饱和化合物的羰基化反应的方法、反应介质以及该系统的使用。
• CATALYST SYSTEM
  申请人：Lucite International UK Limited

  公开号：US20150321186A1

  公开（公告）日：2015-11-12

  The present invention provides a catalyst system capable of catalysing the carbonylation of an ethylenically unsaturated compound, which system is obtainable by combining: a) a metal of Group VIB or Group VIIIB or a compound thereof, b) a bidentate phosphine, arsine or stibine ligand, and c) an acid, wherein said ligand is present in at least a 2:1 molar excess compared to said metal or said metal in said metal compound, and that said acid is present in at least a 2:1 molar excess compared to said ligand, a process for the carbonylation of an ethylenically unsaturated compound, a reaction medium, and use of the system.

  本发明提供了一种催化剂系统，能够催化烯丙基不饱和化合物的羰基化反应，该系统可通过以下步骤获得： a）第VIB族或第VIIIB族金属或其化合物； b）二齿膦、砷或锑配体； c）酸； 其中，所述配体的摩尔量至少比所述金属或所述金属化合物中的金属高2:1，所述酸的摩尔量至少比所述配体高2:1。本发明还提供了一种烯丙基不饱和化合物的羰基化反应过程、反应介质和该系统的用途。