| 1132644-63-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环丁烷
• CAS: 1132644-63-3
• 化学式: C₃₀H₃₉N₃O₂
• 分子量: 473.659
• InChiKey: BVDKYCVYZYRHCB-GNKBHMEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.17
• 重原子数：
  35.0
• 可旋转键数：
  3.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  52.65
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  4-(tert-butyl)cyclohexanisocyanate 、 在 三乙胺 作用下， 生成 、
  参考文献：
  名称：

  Spiro-piperidine azetidinones as potent TRPV1 antagonists

  摘要：

  A series of spiro-piperidine azetidinone were synthesized and evaluated as potential TRPV1 antagonists. An important issue of plasma stability was investigated and resolved. Further focused SAR study lead to the discovery of a potent antagonist with good oral pharmacokinetic profile in rat. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.12.024

文献信息

• Spiro-piperidine azetidinones as potent TRPV1 antagonists
  作者：Dong Xiao、Anandan Palani、Robert Aslanian、Brian A. McKittrick、Andrew T. McPhail、Craig C. Correll、P. Tara Phelps、John C. Anthes、Diane Rindgen

  DOI：10.1016/j.bmcl.2008.12.024

  日期：2009.2

  A series of spiro-piperidine azetidinone were synthesized and evaluated as potential TRPV1 antagonists. An important issue of plasma stability was investigated and resolved. Further focused SAR study lead to the discovery of a potent antagonist with good oral pharmacokinetic profile in rat. (C) 2008 Elsevier Ltd. All rights reserved.