2-chloromethyl-5,5-dimethyl-[1,3]dioxane | 6282-80-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: 2-chloromethyl-5,5-dimethyl-[1,3]dioxane
• 英文别名: 2-chloromethyl-5,5-dimethyl-1,3-dioxane；5,5-Dimethyl-2-chlormethyl-dioxan-(1,3)；5,5-Dimethyl-2-chlormethyl-1,3-dioxan；5,5-Dimethyl-2-chlormethyl-m-dioxan；2-(Chloromethyl)-5,5-dimethyl-1,3-dioxane
• CAS: 6282-80-0
• 化学式: C₇H₁₃ClO₂
• mdl: MFCD19232333
• 分子量: 164.632
• InChiKey: SWKNHIFWKFUIKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-chloromethyl-5,5-dimethyl-[1,3]dioxane 在 silica gel 作用下， 生成 3-(2-chloro-ethoxy)-2,2-dimethyl-propionaldehyde
  参考文献：
  名称：

  A New Rearrangement. Catalytic Isomerization of m-Dioxanes to β-Alkoxy Aldehydes. II. Scope and Limitations

  摘要：

  DOI：

  10.1021/ja00876a018
• 作为产物：
  描述：

  氯乙醛 、 2,2-二甲基-1,3-丙二醇 在 phosphorus modified SO₄^(2-)/TiO₂ 作用下， 以 环己烷 为溶剂， 反应 2.0h， 以98%的产率得到2-chloromethyl-5,5-dimethyl-[1,3]dioxane
  参考文献：
  名称：

  PHOSPHORUS PROMOTED SO4(2-)/TiO2 SOLID ACID CATALYST FOR ACETALIZATION REACTION

  摘要：

  A novel phosphorus modified SO42-/TiO2 catalyst was synthesized by a facile coprecipitation method, followed by calcination. The catalytic performance of this novel solid acid was evaluated by acetalization. The results showed that the phosphorus was very efficient to enhance the catalytic activity of SO42-/TiO2. The solid acid owned high activity for the acetalization with the yields over 90%. Moreover, the solid acid could be reused for six times without loss of initial catalytic activities.

  DOI：

  10.4067/s0717-97072015000300006

文献信息

• Imidazole derivatives and salts thereof, their synthesis, and pharmaceutical formulations
  申请人：THE WELLCOME FOUNDATION LIMITED

  公开号：EP0003560A2

  公开（公告）日：1979-08-22

  Pharmaceutical formulations comprising an imidazole (or pharmaceutically acceptable salt thereof) of formula: wherein (i) A is an aliphatic hydrocarbon residue of from 1 to 4 carbon atoms and R is a naphthyl, tetrahydronaphthyl, heterocyclyl, arylthio, arylalkylthio, aryloxy, arylalkyloxy, arylhydroxymethylene, arylcarbonyl, arylalkylcarbonyl, alkyloxy, alkylthio or a substituted cycloalkyl or cycloalkenyl group or (ii) A is a -S02- group and R is aryl or heterocyclyl or (iii) A is a chemical bond and R is a heterocyclyl or substituted phenyl group, or (iv) A is an aliphatic hydrocarbon residue of from 1 to 3 carbon atoms and R is a halophenyl group. Some of these imidazoles and salts are novel. Methods of preparing the imidazoles are disclosed. The imidazoles and their salts are useful in the treatment or prophylaxis of thrombo-embolic conditions.

  药物制剂，包含式中的咪唑（或其药学上可接受的盐）： 其中 (i) A 是 1 至 4 个碳原子的脂族烃残基，R 是萘基、四氢萘基、杂环基、芳硫基、芳烷硫基、芳氧基、芳烷氧基、芳羟甲基、芳羰基、芳烷基羰基、烷氧基、烷硫基或取代的环烷基或环烯基，或 (ii) A 是-S02-基团，R 是芳基或杂环基，或 (iii) A 是化学键，R 是杂环基或取代苯基，或 (iv) A 是 1 至 3 个碳原子的脂肪烃残基，R 是卤代苯基。 其中一些咪唑和盐是新型的。 这些咪唑的制备方法已经公开。咪唑及其盐类可用于治疗或预防血栓栓塞。
• Synthesis of a novel ionic liquid with both Lewis and Brønsted acid sites and its catalytic activities
  作者：Xuezheng Liang、Chenze Qi

  DOI：10.1016/j.catcom.2011.01.018

  日期：2011.4

  The novel ionic liquid with both Lewis and Bronsted acid sites has been synthesized and its catalytic activities for acetalization and Michael addition were investigated carefully. The novel ionic liquid was stable to water and could be used in aqueous solution. Furthermore, the molar ratio of the Lewis and Bronsted acid sites could be adjusted according to different reactions. The results showed that the novel ionic liquid was very efficient for the traditional acid-catalyzed reactions with good to excellent yields in short time. (C) 2011 Elsevier B.V. All rights reserved.
• Synthesis of a novel melamine-formaldehyde resin-supported ionic liquid with Brønsted acid sites and its catalytic activities
  作者：Guiying Xing

  DOI：10.1007/s00706-013-1022-7

  日期：2013.9

  Bronsted acidic ionic liquid immobilized on a melamine-formaldehyde resin (AIL-MFR) was synthesized through the reaction of melamine-formaldehyde resin (MFR) with 1,4-butanesulfonate. Using PEG-2000 as the additive, the MFR can be prepared in regular microspheres with an average diameter of 3.97 mu m and surface area of 9.09 m(2) g(-1). The AIL-MFR had high acidity of 2.93 mmol g(-1), mainly from the sulfonic groups. The catalysis results showed that the AIL-MFR had high activity and stability for acetalization with excellent conversions and yields for most substrates. Furthermore, immobilization of the acidic ionic liquid on the MFR made the recycling of the catalyst convenient.
• Polyacrylonitrile fiber mat supported solid acid catalyst for acetalization
  作者：Linjun Shao、Yijun Du、Guiying Xing、Weixi Lv、Xuezheng Liang、Chenze Qi

  DOI：10.1007/s00706-011-0706-0

  日期：2012.8

  A novel polyacrylonitrile hybrid fiber mat supported solid acid catalyst was prepared by electrospinning, and its catalytic activities were carefully investigated through acetalization reactions. The results showed that this hybrid fiber mat exhibits high activity for the reactions, with average yields over 95%. Besides having catalytic activities similar to the solid acid, the heterogeneous solid acid/polyacrylonitrile mat can be reused in six runs without significant loss of catalytic activities. The large size of the hybrid fiber mat greatly facilitates recovery of the catalyst from the reaction mixture. The high and stable catalytic activities of the hybrid fiber mat hold great potential for green chemical processes and preparation of membrane reactors in the future..
• Synthesis of novel solid acidic ionic liquid polymer and its catalytic activities
  作者：Xuezheng Liang

  DOI：10.1134/s0023158413060062

  日期：2013.11

  The novel solid acidic ionic liquid polymer has been synthesized through the copolymerization of acidic ionic liquid oligomers and resorcinol-formaldehyde (RF resin). The catalytic activities were investigated through the acetalization. The results showed that the PIL was very efficient for the reactions with the average yield over 99.0%. The procedure was quite simple with just one-step to complete both the reactions. The high hydrophobic BET surface, high catalytic activities and high stability gave the PIL great potential for green chemical processes.