4-methyl-6-morpholino-1,3,5-triazin-2-amine | 5122-64-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三嗪类
• 英文名称: 4-methyl-6-morpholino-1,3,5-triazin-2-amine
• 英文别名: 4-Amino-2-methyl-6-morpholino-1,3,5-triazin；4-methyl-6-morpholin-4-yl-1,3,5-triazin-2-amine；4-methyl-6-morpholin-4-yl-[1,3,5]triazin-2-ylamine
• CAS: 5122-64-5
• 化学式: C₈H₁₃N₅O
• mdl: MFCD15203587
• 分子量: 195.224
• InChiKey: DMCZYRDOKLOQDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  77.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  4-methyl-6-morpholino-1,3,5-triazin-2-amine 在 platinum(IV) oxide 、 氢气 作用下， 以 甲醇 、 水 、 二甲基亚砜 为溶剂， 反应 27.0h， 生成 4-(4-methyl-3,4-dihydroimidazo[1,2-a][1,3,5]triazin-2-yl)morpholine
  参考文献：
  名称：

  Regioselective synthesis of imidazo[1,2-a][1,3,5]triazines and 3,4-dihydroimidazo[1,2-a][1,3,5]triazines from [1,3,5]triazin-2,4-diamines

  摘要：

  An efficient and practical procedure was developed to prepare novel imidazo[1,2-a][1,3,5]triazines and 3,4-dihydroimidazo[1,2-a][1,3,5]triazines with a good regioselectivity and high yields, starting from di-cyandiamide and the corresponding arylamines. Mechanistic studies for the subsequent cyclo-condensation with chloroacetaldehyde support a pathway, which begins with the displacement of the chloro atom activated by an adjacent CO group, followed by cyclization and dehydration. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.03.039
• 作为产物：
  描述：

  moroxydine hydrochloride 、 乙酸乙酯 在 sodium methylate 作用下， 以 四氢呋喃 为溶剂， 反应 36.0h， 生成 4-methyl-6-morpholino-1,3,5-triazin-2-amine
  参考文献：
  名称：

  一种基于三嗪环结构限定性N-(2-胍基-乙亚 氨基)-吗啉抗原、抗体及应用

  摘要：

  本发明一种基于三嗪环结构限定性N‑(2‑胍基‑乙亚氨基)‑吗啉半抗原、人工抗原、抗体及应用。所述N‑(2‑胍基‑乙亚氨基)‑吗啉半抗原的结构如式I所示：其中R为‑H和‑CH3。并以此制备了N‑(2‑胍基‑乙亚氨基)‑吗啉人工抗原和抗体，对N‑(2‑胍基‑乙亚氨基)‑吗啉的检测效率高、操作简便，可用于N‑(2‑胍基‑乙亚氨基)‑吗啉的酶联免疫快速检测；且本发明的抗原抗体合成过程简单、成本较低，具有良好的应用前景。

  公开号：

  CN108059622B

文献信息

• High yielding microwave-assisted synthesis of tri-substituted 1,3,5-triazines using Pd-catalyzed aryl and heteroarylamination
  作者：Pascal Dao、Christiane Garbay、Huixiong Chen

  DOI：10.1016/j.tet.2012.03.041

  日期：2012.5

  A rapid and efficient Pd-catalyzed aryl and heteroarylamination under microwave irradiation has been developed for various tri-substituted triazines that can serve as versatile building blocks for both supramolecular and medicinal chemistry research. Particularly valuable features of this method included the short reaction time, good yield, and convenient operation. (C) 2012 Elsevier Ltd. All rights reserved.
• [EN] A METHOD FOR MODIFYING A LIPASE<br/>[FR] PROCÉDÉ DE MODIFICATION D'UNE LIPASE
  申请人：NOVOZYMES AS

  公开号：WO2015181117A1

  公开（公告）日：2015-12-03

  The present invention relates to a method for modifying one or more characteristics of a lipase, comprising the step of associating a peptide to the lipase, wherein the peptide has at least 50% sequence identity with the amino acid sequence of at least one major lipase contact zone of the propeptide of said lipase.
• Regioselective synthesis of imidazo[1,2-a][1,3,5]triazines and 3,4-dihydroimidazo[1,2-a][1,3,5]triazines from [1,3,5]triazin-2,4-diamines
  作者：Pascal Dao、Christiane Garbay、Huixiong Chen

  DOI：10.1016/j.tet.2013.03.039

  日期：2013.5

  An efficient and practical procedure was developed to prepare novel imidazo[1,2-a][1,3,5]triazines and 3,4-dihydroimidazo[1,2-a][1,3,5]triazines with a good regioselectivity and high yields, starting from di-cyandiamide and the corresponding arylamines. Mechanistic studies for the subsequent cyclo-condensation with chloroacetaldehyde support a pathway, which begins with the displacement of the chloro atom activated by an adjacent CO group, followed by cyclization and dehydration. (C) 2013 Elsevier Ltd. All rights reserved.
• 一种基于三嗪环结构限定性N-(2-胍基-乙亚 氨基)-吗啉抗原、抗体及应用
  申请人：华南农业大学

  公开号：CN108059622B

  公开（公告）日：2021-03-12

  本发明一种基于三嗪环结构限定性N‑(2‑胍基‑乙亚氨基)‑吗啉半抗原、人工抗原、抗体及应用。所述N‑(2‑胍基‑乙亚氨基)‑吗啉半抗原的结构如式I所示：其中R为‑H和‑CH3。并以此制备了N‑(2‑胍基‑乙亚氨基)‑吗啉人工抗原和抗体，对N‑(2‑胍基‑乙亚氨基)‑吗啉的检测效率高、操作简便，可用于N‑(2‑胍基‑乙亚氨基)‑吗啉的酶联免疫快速检测；且本发明的抗原抗体合成过程简单、成本较低，具有良好的应用前景。