(S)-1,6,9-Trimethyl-2-oxa-bicyclo[3.3.1]nonane-6,9-diol | 143771-44-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: (S)-1,6,9-Trimethyl-2-oxa-bicyclo[3.3.1]nonane-6,9-diol
• CAS: 143771-44-2
• 化学式: C₁₁H₂₀O₃
• 分子量: 200.278
• InChiKey: YFDBZBUYURJXHQ-MWJCJQSMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.08
• 重原子数：
  14.0
• 可旋转键数：
  0.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  49.69
• 氢给体数：
  2.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  甲基溴化镁 、 Pyrano[3,2-b]pyran-2(3H)-one, 4,4a,6,7-tetrahydro-4a-methyl-, (S)- 生成 (S)-1,6,9-Trimethyl-2-oxa-bicyclo[3.3.1]nonane-6,9-diol
  参考文献：
  名称：

  Enantioselective synthesis of 2,2-dialkyltetrahydropyran-3-ones via the asymmetric Michael addition reaction using chiral imines

  摘要：

  Addition of chiral imine 8 derived from 2-methyltetrahydropyran-3-one 7 and R-(+)-1-phenylethylamine, to methyl acrylate led to adduct (S)-9 with a good yield and an excellent stereoselectivity.

  DOI：

  10.1016/s0957-4166(00)82185-0

文献信息

• Enantioselective synthesis of 2,2-dialkyltetrahydropyran-3-ones via the asymmetric Michael addition reaction using chiral imines
  作者：Didier Desmaële、Gilles Pain、Jean d'Angelo

  DOI：10.1016/s0957-4166(00)82185-0

  日期：1992.7

  Addition of chiral imine 8 derived from 2-methyltetrahydropyran-3-one 7 and R-(+)-1-phenylethylamine, to methyl acrylate led to adduct (S)-9 with a good yield and an excellent stereoselectivity.