3-(4-hydroxy-3-methoxy-phenyl)-2-phenyl-acrylic acid | 87751-70-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 3-(4-hydroxy-3-methoxy-phenyl)-2-phenyl-acrylic acid
• 英文别名: 3-(4-Hydroxy-3-methoxy-phenyl)-2-phenyl-acrylsaeure；4'-Oxy-3'-methoxy-stilben-α-carbonsaeure；4-Oxy-3-methoxy-α-phenyl-zimtsaeure；3-(4-Hydroxy-3-methoxyphenyl)-2-phenylprop-2-enoic acid；(Z)-3-(4-hydroxy-3-methoxyphenyl)-2-phenylprop-2-enoic acid
• CAS: 87751-70-0
• 化学式: C₁₆H₁₄O₄
• 分子量: 270.285
• InChiKey: ARPNBQDBKNKVII-LCYFTJDESA-N

物化性质

• 熔点：
  186-187 °C
• 沸点：
  410.8±40.0 °C(Predicted)
• 密度：
  1.289±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  sodium phenylacetate 、 香草醛 在 乙酸酐 作用下， 生成 3-(4-hydroxy-3-methoxy-phenyl)-2-phenyl-acrylic acid
  参考文献：
  名称：

  Dey; Row, Journal of the Indian Chemical Society, 1923, vol. 1, p. 287

  摘要：

  DOI：

文献信息

• CIS-1,2-SUBSTITUTED STILBENE DERIVATES AND THE USE THEREROF FOR MANUFACTURING MEDICAMENTS FOR TREATING MEDICAMENTS FOR TREATING AND/OR PREVENTING DIABETES
  申请人：Institute of Radiation Medicine, Academy of Military Medical Sciences Pla

  公开号：EP1801087A1

  公开（公告）日：2007-06-27

  The present invention relates to cis-1,2-substituted stilbene derivatives, or their pharmaceutically acceptable salts, glucosides or solvates, a pharamceutical composition comprising the compound, and use of said compound for preparation of a drug for treatment and/or prevention of diabetes or improvement of diabetic complications.

  本发明涉及顺式-1,2-取代的二苯乙烯衍生物或其药学上可接受的盐、苷或溶液，包含该化合物的药物组合物，以及使用所述化合物制备治疗和/或预防糖尿病或改善糖尿病并发症的药物。
• CIS-1,2-SUBSTITUTED STILBENE DERIVATIVES FOR TREATING AND/OR PREVENTING DIABETES
  申请人：Institute of Radiation Medicine, Academy of Military Medical Sciences Pla

  公开号：EP1801087B1

  公开（公告）日：2012-08-29
• Cis-1,2-substituted stilbene derivatives and their use in preparation of drugs for treatment and/or prevention of diabetes
  申请人：Kang Zhiyun

  公开号：US20090076114A1

  公开（公告）日：2009-03-19

  The present invention relates to cis-1,2-substituted stilbene derivatives, or their pharmaceutically acceptable salts, glucosides or solvates, a pharmaceutical composition comprising the compound, and use of said compound for preparation of a drug for treatment and/or prevention of diabetes or improvement of diabetic complications.
• US8039513B2
  申请人：——

  公开号：US8039513B2

  公开（公告）日：2011-10-18