tributylammonium acetate | 7204-64-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: tributylammonium acetate
• 英文别名: n-tributylammonium acetate；N-tributylamine acetate；tributylamine acetate；acetic acid tributylamine complex；acetic acid tributylamine salt；Tributylammoniumacetat；tributylazanium;acetate
• CAS: 7204-64-0
• 化学式: C₂H₃O₂*C₁₂H₂₈N
• 分子量: 245.406
• InChiKey: ZAMCTDDIJFNXOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.78
• 重原子数：
  17
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  戊醇 、 tributylammonium acetate 以38.1%的产率得到乙酸戊酯
  参考文献：
  名称：

  [EN] RECOVERY OF ORGANIC ACIDS
  [FR] RECUPERATION D'ACIDES ORGANIQUES

  摘要：

  揭示了一种从稀盐溶液中回收有机酸的方法，其中盐的阳离子形成不溶性碳酸盐。向溶液中加入三级胺和COZ以形成不溶性碳酸盐和酸与胺之间的复合物。添加水不相溶的溶剂，如醇，以从稀盐溶液中提取酸/胺复合物到反应相。反应相持续干燥，形成酸与溶剂之间的产物，如酯。

  公开号：

  WO2005073161A1
• 作为产物：
  描述：

  三正丁胺 、 溶剂黄146 反应 8.0h， 生成 tributylammonium acetate
  参考文献：
  名称：

  质子离子液体和P123的自组装结构转变用于诱导分层多孔材料

  摘要：

  以质子离子液体（NTA）和P123为共模板，制备了一系列具有分级孔体系的硅锆材料。控制目标目标形成的因素

  DOI：

  10.1039/c6ra02075e

文献信息

• [EN] ANIONIC OLIGOSACCHARIDE CONJUGATES<br/>[FR] CONJUGUÉS D'OLIGOSACCHARIDES ANIONIQUES
  申请人：GLYCAN BIOSCIENCES PTY LTD

  公开号：WO2010037180A1

  公开（公告）日：2010-04-08

  The invention relates to anionic oligosaccharide conjugates that may be used to mimic the structure and/or activity of the anionic bioactive molecules known as glycosaminoglycans (GAGs).

  该发明涉及阴离子寡糖共轭物，可用于模拟被称为糖胺聚糖（GAGs）的阴离子生物活性分子的结构和/或活性。
• Preparation of protic ionic liquids with minimal water content and 15N NMR study of proton transfer
  作者：Geoffrey L. Burrell、Iko M. Burgar、Frances Separovic、Noel F. Dunlop

  DOI：10.1039/b921432a

  日期：——

  Low-molecular-weight Brønsted acids and amine bases were used to reproducibly prepare very dry, high-purity room-temperature protic ionic liquids (PILs). A series of eight amine bases and six Brønsted acids were combined to produce 48 mixtures, of which 18 were liquid at room temperature. The phase transitions and thermal decomposition temperatures were determined for each mixture; whereas viscosity, density and conductivity were determined for the room-temperature liquids. By utilising 15N NMR it was possible to distinguish between neutral and ionised amine bases (ammonia vs. ammonium-type ion), which indicated that the protic ionic liquids were completely ionised when made as a stoichiometric mixture. However, a Walden plot comparison of fluidity and molar conductivity indicated the majority of PILs had much lower conductivity than predicted by viscosity unless the base contained excess proton-donating groups. This disparity is indicative of protic ionic molecules forming neutral aggregates or non-Newtonian fluid hydrogen-bonded networks with a secondary Grotthuss proton-hopping mechanism arising from polyprotic bases.

  低分子量的布朗斯特酸和胺碱被用来重复制备非常干燥、高纯度的室温质子型离子液体（PILs）。将一系列八种胺碱和六种布朗斯特酸组合，产生了48种混合物，其中18种在室温下为液态。每种混合物的相变和热分解温度被测定；而室温液体的粘度、密度和电导率也被测定。通过利用15N NMR，能够区分中性和离子化的胺碱（氨与铵型离子），这表明在作为化学计量混合物制备时，质子型离子液体是完全离子化的。然而，流动性和摩尔电导率的沃尔登图比较表明，除了当碱包含过量的质子给体基团时，大多数PIL的电导率远低于粘度所预测的值。这种差异表明，质子型离子分子形成了中性聚集体或非牛顿流体氢键网络，并出现了由多质子碱引起的次级格罗图斯质子跳跃机制。
• LIPID FORMULATED SINGLE STRANDED RNA
  申请人：Manoharan Muthiah

  公开号：US20130156845A1

  公开（公告）日：2013-06-20

  The present invention provides compositions comprising a nucleic acid lipid particle and an oligomeric compound and uses thereof. In certain embodiments, such compositions are useful as antisense compounds. Certain such antisense compounds are useful as RNase H antisense compounds or as RNAi compounds.

  本发明提供了包含核酸脂质粒子和寡核苷酸化合物的组合物及其用途。在某些实施方式中，这些组合物可用作反义物质。某些这样的反义物质可用作RNase H反义物质或RNAi物质。
• Understanding the Role of Protic Ionic Liquids (PILs) in Reactive Systems: Rational Selection of PILs for the Design of Green Synthesis Strategies for Allylic Amines and β‐Amino Esters
  作者：María V. Bravo、José L. Fernández、Claudia G. Adam、Claudia D. Della Rosa

  DOI：10.1002/cplu.201900318

  日期：2019.7

  acid and amine. In reactive systems, these free species determine the products of the reaction. In particular, allylic amines and β-amino esters were obtained in good yields (91 and 75 %, respectively) by reaction of conjugated dienes and acrylates in the presence of PILs. By taking into account the actual composition of each PIL, it was possible to direct the reaction path towards a specific product

  已显示质子离子液体（PIL）的反应行为不仅受其化学结构控制，而且受其整体组成控制，其中包括与离子对平衡存在的游离酸和碱。在与不饱和底物的模型反应中，测试了由伯，仲或叔烷基铵阳离子与两个巯基硝酸盐或乙酸盐组成的六个PIL。通过循环伏安法鉴定了这些液体中天然存在的游离物种。发现只有硝酸三丁铵主要由离子对组成；其他五个PIL也包含可变数量的游离酸和胺。在反应体系中，这些游离物质决定了反应的产物。特别是，获得了高收率的烯丙基胺和β-氨基酯（91％和75％，在PIL的存在下，通过共轭二烯与丙烯酸酯的反应进行反应）。通过考虑每个PIL的实际组成，可以将反应路径以高收率导向特定的产物，以确保酸催化，避免底物聚合，并促进产物的相转移。这些结果为合理设计新的基于PIL的一步合成策略建立了一些有用的指导。
• [EN] RECOVERY OF ORGANIC ACID USING A COMPLEX EXTRACTION SOLVENT<br/>[FR] RÉCUPÉRATION D'ACIDE ORGANIQUE À L'AIDE D'UN SOLVANT D'EXTRACTION COMPLEXE
  申请人：ZEACHEM INC

  公开号：WO2012054400A1

  公开（公告）日：2012-04-26

  A method is disclosed for the recovery of an organic acid from a dilute salt solution in which the cation of the salt forms an insoluble carbonate salt. An amine, C02 and a water immiscible solvent are introduced to the solution to form the insoluble carbonate salt and a complex between the acid and the amine that is soluble in both an aqueous and a solvent phase. The complex is extracted into the solvent phase which is than distilled to recover the acid or an ester of the acid in a concentrated form.

  本方法揭示了一种从稀盐溶液中回收有机酸的方法，其中盐的阳离子形成不溶性碳酸盐。向溶液中加入胺、二氧化碳和不溶于水的溶剂，以形成不溶性碳酸盐和酸与胺之间的复合物，该复合物在水相和溶剂相中均可溶解。复合物被萃取到溶剂相中，然后蒸馏以回收酸或酸的酯以浓缩形式。