5,6-dichloro-3-phenyl-1H-indene | 1615711-02-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: 5,6-dichloro-3-phenyl-1H-indene
• CAS: 1615711-02-8
• 化学式: C₁₅H₁₀Cl₂
• 分子量: 261.15
• InChiKey: FXWBYJFKNTVAFC-UHFFFAOYSA-N

物化性质

• 沸点：
  373.2±42.0 °C(predicted)
• 密度：
  1.319±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  肉桂醛 、 邻二氯苯 在 aluminum (III) chloride 作用下， 反应 5.0h， 以80%的产率得到5,6-dichloro-3-phenyl-1H-indene
  参考文献：
  名称：

  Synthesis of indenes via aluminum chloride-promoted tandem Friedel–Crafts alkylation of arenes and cinnamaldehydes

  摘要：

  A series of substituted indenes were synthesized from arenes and cinnamaldehydes via aluminum chloride-promoted tandem Friedel-Crafts alkylation. The scope and limitation of the tandem reaction were explored. A plausible reaction mechanism is also discussed. This approach provides a convenient method for the synthesis of indene derivatives using a readily available and low cost Lewis acid and starting materials. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2014.04.027

文献信息

• Synthesis of indenes via aluminum chloride-promoted tandem Friedel–Crafts alkylation of arenes and cinnamaldehydes
  作者：Haiouani Kheira、Pingfan Li、Jiaxi Xu

  DOI：10.1016/j.molcata.2014.04.027

  日期：2014.9

  A series of substituted indenes were synthesized from arenes and cinnamaldehydes via aluminum chloride-promoted tandem Friedel-Crafts alkylation. The scope and limitation of the tandem reaction were explored. A plausible reaction mechanism is also discussed. This approach provides a convenient method for the synthesis of indene derivatives using a readily available and low cost Lewis acid and starting materials. (C) 2014 Elsevier B.V. All rights reserved.