Provided herein are methods of treating or ameliorating hypercholemia or a cholestatic liver disease by administering to an individual in need thereof a therapeutically effective amount of an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof. Also provided are methods for treating or ameliorating a liver disease, decreasing the levels of serum bile acids or hepatic bile acids, treating or ameliorating pruritis, reducing liver enzymes, or reducing bilirubin comprising administering to an individual in need thereof a therapeutically effective amount of ASBTI or a pharmaceutically acceptable salt thereof.
本文提供了一种治疗或改善高
胆固醇血症或胆汁淤积性肝病的方法,即通过向需要的个体施用治疗有效量的顶端
钠依赖性
胆酸转运蛋白
抑制剂(
ASBTI)或其药用可接受盐。还提供了一种治疗或改善肝病、降低血清
胆酸或肝内
胆酸水平、治疗或改善瘙痒、降低肝酶或减少
胆红素的方法,即通过向需要的个体施用治疗有效量的
ASBTI或其药用可接受盐。