| 1453100-89-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 1453100-89-4
• 化学式: C₂₄H₁₈CuN₂O₃
• 分子量: 445.965
• InChiKey: ZNYPQEOYFLBCTR-MPQAZLLSSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  N,N'-bis(salicylaldehyde)-2,3-diaminonaphthalene 、 copper(II) acetate monohydrate 以 乙硫醇 为溶剂， 反应 4.0h， 生成
  参考文献：
  名称：

  Synthesis, characterization, and DNA binding of a novel ligand and its Cu(II) complex

  摘要：

  A novel naphthalene-2,3-diamine-2-salicylaldehyde (NS) ligand and its mononuclear copper(II) complex (CuNS) have been synthesized and structurally characterized. The UV-vis absorption and emission spectra of NS showed obvious changes on addition of Cu2+ solution. The interaction of the compounds with calf thymus DNA and G-quadruplex DNA were investigated by spectroscopic methods and thermal melting assay. The nucleolytic cleavage activity of the compounds was investigated on double-stranded circular pBR322 plasmid DNA and G-quadruplex DNA by electrophoretic mobility shift assay. The results show that CuNS has a greater ability to stabilize G-quadruplex DNA over calf-thymus DNA. The cytotoxicity of the compounds toward HpeG2 cancer cells was also studied, and they showed significant potential for antineoplastic effects.

  DOI：

  10.1007/s00775-013-1048-7

文献信息

• Synthesis, characterization, and DNA binding of a novel ligand and its Cu(II) complex
  作者：Mei-Jin Li、Tao-Yu Lan、Zhi-Shan Lin、Changqing Yi、Guo-Nan Chen

  DOI：10.1007/s00775-013-1048-7

  日期：2013.12

  A novel naphthalene-2,3-diamine-2-salicylaldehyde (NS) ligand and its mononuclear copper(II) complex (CuNS) have been synthesized and structurally characterized. The UV-vis absorption and emission spectra of NS showed obvious changes on addition of Cu2+ solution. The interaction of the compounds with calf thymus DNA and G-quadruplex DNA were investigated by spectroscopic methods and thermal melting assay. The nucleolytic cleavage activity of the compounds was investigated on double-stranded circular pBR322 plasmid DNA and G-quadruplex DNA by electrophoretic mobility shift assay. The results show that CuNS has a greater ability to stabilize G-quadruplex DNA over calf-thymus DNA. The cytotoxicity of the compounds toward HpeG2 cancer cells was also studied, and they showed significant potential for antineoplastic effects.