(9-diethylamino-benzo[a]phenoxazin-5-ylidene)-phenyl-amine | 7385-73-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 英文名称: (9-diethylamino-benzo[a]phenoxazin-5-ylidene)-phenyl-amine
• 英文别名: Nil-Blau；(9-diethylamino-benzo[a]phenoxazin-5-ylidene)-phenyl-amine
• CAS: 7385-73-1
• 化学式: C₂₆H₂₃N₃O
• 分子量: 393.488
• InChiKey: ZDNCMNRXKKHIBI-VYIQYICTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.16
• 重原子数：
  30.0
• 可旋转键数：
  4.0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  41.63
• 氢给体数：
  0.0
• 氢受体数：
  4.0

文献信息

• MEDICINAL COMPOSITION CONTAINING BENZO[A]PHENOXANTHIN COMPOUND AS THE ACTIVE INGREDIENT FOR PREVENTING OR TREATING PROTOZOAL DISEASE
  申请人：Hoshi University

  公开号：EP2269996A1

  公开（公告）日：2011-01-05

  Provided is a medicinal composition, in particular, a medicinal composition for treatment and/or prevention which has a high therapeutic effect on infection with a parasitic protozoa and a selective toxicity thereto and exhibits a life-prolonging effect and so on. A medicinal composition which contains as the active ingredient a benzo[a]phenoxazine compound represented by General formula (1) or a salt compound of the same, in particular, an agent for treating and/or preventing infection with a protozoa such as malaria, leishmaniasis, African trypanosomiasis, Chagas disease, toxoplasmosis, lymphatic filariasis, babesiosis or coccidium disease; and a novel compound which is contained therein as the active ingredient.

  本发明提供了一种药物组合物，特别是一种用于治疗和/或预防寄生原虫感染的药物组合物，该药物组合物对寄生原虫感染具有较高的治疗效果和选择性毒性，并具有延长生命等效果。一种药物组合物，其活性成分为通式（1）代表的苯并[a]吩噁嗪化合物或其盐类化合物，特别是一种用于治疗和/或预防疟疾、利什曼病、非洲锥虫病、南美锥虫病、弓形虫病、淋巴丝虫病、巴贝丝虫病或球虫病等原虫感染的药物；以及一种新型化合物，其活性成分为通式（1）代表的苯并[a]吩噁嗪化合物或其盐类化合物。
• MEDICINAL COMPOSITION CONTAINING BENZO[A]PHENOXAZINE COMPOUND AS THE ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF PROTOZOAL DISEASE
  申请人：Ihara Masataka

  公开号：US20110021450A1

  公开（公告）日：2011-01-27

  Provided is a medicinal composition, in particular, a medicinal composition for treatment and/or prevention which has a high therapeutic effect on infection with a parasitic protozoa and a selective toxicity thereto and exhibits a life-prolonging effect and so on. A medicinal composition which contains as the active ingredient a benzo[a]phenoxazine compound represented by General formula (1) or a salt compound of the same, in particular, an agent for treating and/or preventing infection with a protozoa such as malaria, leishmaniasis, African trypanosomiasis, Chagas disease, toxoplasmosis, lymphatic filariasis, babesiosis or coccidium disease; and a novel compound which is contained therein as the active ingredient.
• US8288374B2
  申请人：——

  公开号：US8288374B2

  公开（公告）日：2012-10-16