N-(4-(2-(((2-methoxy-10H-phenothiazin-1-yl)methyl)amino)ethyl)phenyl)thiophene-2-carboximidamide | 262447-14-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: N-(4-(2-(((2-methoxy-10H-phenothiazin-1-yl)methyl)amino)ethyl)phenyl)thiophene-2-carboximidamide
• CAS: 262447-14-3
• 化学式: C₂₇H₂₆N₄OS₂
• 分子量: 486.7
• InChiKey: YHCNRLKLYZAKBS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• N-(iminomethyl)amines derivatives, their preparation, their use as medicines and compositions containing them
  申请人：Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)

  公开号：US06482822B1

  公开（公告）日：2002-11-19

  The invention concerns novel N-(iminomethyl)amine derivatives comprising in their skeleton the aminophenylamine, oxodiphenylamine, carbazole, phenazine, phenoxazine or oxodiphenyl motif, their use as medicines and pharmaceutical compositions containing them. The invention concerns in particular the following compounds: -4-{[2-thienyl(imino)methyl]amino}-N-[2-(phenylamino)phenyl]-benzenebutanamide; -4-{[2-thienyl(imino)methyl]amino}-N-[4-(phenylamino)phenyl]-benzenebutanamide; -N-′[4-(10H-phenothiazin-2-yloxy)phenyl]-2-thiophenecarboximidamide; -4-(4-{[amino(2-thienyl)methylidene]amino}phenyl)-N-(10H-phenothiazin-3-ylH)butanamide; -3-[(3-{[amino(2-thienyl)methylidene]amino}-benzyl)amino]-N-(4-anilinophenyl)propanamide; -N′-(4-{2-[(10H-phenothiazin-3-ylmethyl)amino]ethyl}phenyl-2-thiophene carboximidamide.

  该发明涉及新颖的N-(亚甲基亚胺)胺衍生物，其骨架中包含氨基苯胺、氧代二苯胺、咔唑、苯并嗪、苯氧嗪或氧代二苯基团，以及它们作为药物的用途和含有它们的药物组合物。该发明特别涉及以下化合物：-4-【2-噻吩基(亚甲基)氨基】-N-[2-(苯胺基)苯基]苯丁酰胺；-4-【2-噻吩基(亚甲基)氨基】-N-[4-(苯胺基)苯基]苯丁酰胺；-N-′[4-(10H-苯并噻嗪-2-氧基)苯基]-2-噻吩羧酰亚胺；-4-(4-【氨基(2-噻吩基)甲基亚胺】苯基)-N-(10H-苯并噻嗪-3-基)丁酰胺；-3-[(3-【氨基(2-噻吩基)甲基亚胺】苯基)-N-(4-苯胺基苯基)丙酰胺；-N′-(4-[2-(10H-苯并噻嗪-3-基甲基)氨基]乙基苯基-2-噻吩羧酰亚胺。
• New derivatives of N-(iminomethy)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them
  申请人：SOCIETE DE CONSEILS DE RECHERCHES D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)

  公开号：US20040097494A1

  公开（公告）日：2004-05-20

  N-(imino)amines and their preparation and their use as NO synthase inhibitors and selective or non-selective traps for a reactive oxygen species.

  N-(亚胺基)胺及其制备方法，以及作为NO合酶抑制剂和对反应性氧化物的选择性或非选择性陷阱的用途。
• Derivatives of N-(iminomethyl)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them
  申请人：Bigg Dennis

  公开号：US20050197329A1

  公开（公告）日：2005-09-08

  N-(imino)amines and their preparation and their use as NO synthase inhibitors and selective or non-selective traps for a reactive oxygen species.

  N-(亚硝基)胺及其制备方法和用作NO合酶抑制剂和选择性或非选择性捕捉反应性氧化物种的用途。
• New derivatives of N-(iminomethyl)amines, their preparation, their use as medicaments and the pharmaceutical compositions containing them
  申请人：Bigg Dennis

  公开号：US20050027009A1

  公开（公告）日：2005-02-03

  N-(imino)amines and their preparation and their use as NO synthase inhibitors and selective or non-selective traps for a reactive oxygen species.

  N-(亚硝基)胺及其制备方法和用途，作为NO合酶抑制剂和选择性或非选择性的反应性氧化物陷阱。
• DERIVES DE N-(IMINOMETHYL)AMINES, LEUR PREPARATIONLEUR APPLICATION A TITRE DE MEDICAMENTS ET LES COMPOSITI ONS PHARMACEUTIQUES LES CONTENANT
  申请人：SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.)

  公开号：EP1115720B1

  公开（公告）日：2008-07-02