2-bromo-N-[2-(3,4-dihydroxyphenyl)ethyl]propionamide | 862673-06-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-bromo-N-[2-(3,4-dihydroxyphenyl)ethyl]propionamide
• 英文别名: 2-Bromo-N-[2-(3,4-dihydroxyphenyl)ethyl]propanamide
• CAS: 862673-06-1
• 化学式: C₁₁H₁₄BrNO₃
• 分子量: 288.141
• InChiKey: LGZVAJNPGRBFOC-UHFFFAOYSA-N

物化性质

• 沸点：
  515.6±50.0 °C(Predicted)
• 密度：
  1.531±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  69.6
• 氢给体数：
  3
• 氢受体数：
  3

安全信息

• 储存条件：
  2-8°C

反应信息

• 作为产物：
  描述：

  盐酸多巴胺 、 2-溴丙酰溴 在 Sodium tetraborate decahydrate 作用下， 以 水 为溶剂， 反应 0.5h， 以33%的产率得到2-bromo-N-[2-(3,4-dihydroxyphenyl)ethyl]propionamide
  参考文献：
  名称：

  Biomimetic Anchor for Surface-Initiated Polymerization from Metal Substrates

  摘要：

  In this paper, we demonstrate the first use of a catecholic initiator for surface-initiated polymerization (SIP) from metal surfaces to create antifouling polymer coatings. A new bifunctional initiator inspired by mussel adhesive proteins was synthesized, which strongly adsorbs to Ti and 316L stainless steel (SS) substrates, providing an anchor for surface immobilization of grafted polymers. Surface-initiated atom transfer radical polymerization (SI-ATRP) was performed through the adsorbed biomimetic initiator to polymerize methyl methacrylate macromonomers with oligo(ethylene glycol) (OEG) side chains. X-ray photoelectron spectroscopy, surface FT-IR, and contact angle analysis confirmed the sequential grafting of initiator and polymer, and ellipsometry indicated the formation of polymer coatings of up to 100 nm thickness. Cell adhesion experiments performed with 3T3-Swiss albino fibroblasts showed substantially reduced cell adhesion onto polymer grafted Ti and 316L SS substrates as compared to the unmodified metals. Moreover, micropatterning of grafted polymer coatings on Ti surfaces was demonstrated by combining SI-ATRP and molecular assembly patterning by lift-off (MAPL), creating cell-adhesive and cell-resistant regions for potential use as cell arrays. Due to the ability of catechols to bind to a large variety of inorganic surfaces, this biomimetic anchoring strategy is expected to be a highly versatile tool for polymer thin film surface modification for biomedical and other applications.

  DOI：

  10.1021/ja0532638

文献信息

• [EN] PROCESS FOR THE SYNTHESIS OF STIMULUS-RESPONSIVE MAGNETIC NANOPARTICLES<br/>[FR] PROCÉDÉ DE SYNTHÈSE DE NANOPARTICULES MAGNÉTIQUES SENSIBLES À UN STIMULUS
  申请人：FONDAZIONE ST ITALIANO TECNOLOGIA

  公开号：WO2018138677A1

  公开（公告）日：2018-08-02

  Process for preparing magnetic nanoparticles coated with a thermo- or Ph-responsive polymer, characterized in that it comprises the radical polymerization of a monomer or co-monomers susceptible of forming a thermo-polymer or Ph-responsive copolymer in a solution including magnetic nanoparticles functionalized at their surface with a polymerization initiator of formula (I): wherein: R3 is hydrogen or hydroxyl, Hal is a halogen selected from bromine, chlorine and iodine, m is an integer from 1 to 10, preferably from 1 to 3, and R1 and R2, independently of one another, are selected from hydrogen, methyl and phenyl. The coated particles are useful, particularly as carriers of a drug in therapeutic treatments by hyperthermia and/or in situ release of the drug.

  制备热响应或pH响应聚合物包覆磁性纳米颗粒的过程，其特征在于在包含经表面功能化的磁性纳米颗粒的溶液中，通过自由基聚合单体或共聚单体，制备热聚合物或pH响应共聚物。表面功能化磁性纳米颗粒的聚合引发剂的化学式为（I）：其中：R3为氢或羟基，Hal是从溴、氯和碘中选择的卤素，m为1至10的整数，优选为1至3，R1和R2独立选择自氢、甲基和苯基。包覆的颗粒特别适用于作为药物的载体，在高温治疗和/或现场释放药物的治疗中使用。
• Polymeric compositions and related methods of use
  申请人：Messersmith B. Phillip

  公开号：US20060009550A1

  公开（公告）日：2006-01-12

  Methods for surface-initiated atom transfer radical polymerization, which can utilize a catecholic alkyl halide initiator.

  表面引发原子转移自由基聚合的方法，可以利用儿茶酚烷基卤代物引发剂。
• SELECTIVELY PERMEABLE COATED MEMBRANE
  申请人：Klok Harm-Anton

  公开号：US20090112075A1

  公开（公告）日：2009-04-30

  There is provided a selectively permeable biointerface membrane, permitting selective diffusion of analyte therethrough, for use in an analyte sensor comprising a nanoporous substrate and a coating, on the nanoporous substrate, comprising a plurality of polymer chains whereby each polymer chain is attached at one chain end thereof to a surface of the nanoporous substrate. There are also provided methods for the preparation of the selectively permeable membrane and an analyte sensor comprising the membrane.

  提供了一种选择性渗透的生物界面膜，允许分析物透过，用于分析物传感器，包括纳米多孔基板和涂层，在纳米多孔基板上，包括多个聚合物链，每个聚合物链的一端连接在纳米多孔基板的表面上。还提供了制备选择性渗透膜和包括该膜的分析物传感器的方法。
• Selectively permeable coated membrane
  申请人：Sensile Pat AG

  公开号：EP2055226A1

  公开（公告）日：2009-05-06

  There is provided a selectively permeable biointerface membrane, permitting selective diffusion of analyte therethrough, for use in an analyte sensor comprising a nanoporous substrate and a coating, on the nanoporous substrate, comprising a plurality of polymer chains whereby each polymer chain is attached at one chain end thereof to a surface of the nanoporous substrate. There are also provided methods for the preparation of the selectively permeable membrane and an analyte sensor comprising the membrane.

  提供了一种选择性渗透生物界面膜，允许分析物选择性扩散通过，用于分析物传感器，该传感器包括纳米多孔基底和纳米多孔基底上的涂层，涂层包括多个聚合物链，其中每个聚合物链在其一个链端连接到纳米多孔基底的表面。此外，还提供了制备选择性渗透膜和包含该膜的分析传感器的方法。
• Stimuli Responsive Membrane
  申请人：Sensile Pat AG

  公开号：EP2284275A1

  公开（公告）日：2011-02-16

  There is provided a glucose responsive membrane comprising a nanoporous support substrate and a layer of a glucose responsive hydrogel attached to a surface of the nanoporous substrate. There are also provided methods for the preparation of the glucose responsive membrane and a medical device for the monitoring or regulation of glucose levels in a patient comprising the membrane.

  提供了一种葡萄糖反应膜，包括纳米多孔支撑基底和附着在纳米多孔基底表面的一层葡萄糖反应水凝胶。还提供了制备葡萄糖反应膜的方法和用于监测或调节患者血糖水平的医疗设备，该设备包括该膜。