(2E)-3-(1-chloro-6-methoxy-3,4-dihydronaphthalen-2-yl)-N-methoxy-N-methylacrylamide | 1199800-18-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (2E)-3-(1-chloro-6-methoxy-3,4-dihydronaphthalen-2-yl)-N-methoxy-N-methylacrylamide
• 英文别名: (E)-3-(1-chloro-6-methoxy-3,4-dihydronaphthalen-2-yl)-N-methoxy-N-methylprop-2-enamide
• CAS: 1199800-18-4
• 化学式: C₁₆H₁₈ClNO₃
• 分子量: 307.777
• InChiKey: KNCQPEFDOGRWBX-RMKNXTFCSA-N

物化性质

• 熔点：
  107-108 °C
• 沸点：
  417.0±55.0 °C(predicted)
• 密度：
  1.24±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  38.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (2E)-3-(1-chloro-6-methoxy-3,4-dihydronaphthalen-2-yl)-N-methoxy-N-methylacrylamide 、 1-溴-3,5-二甲氧基苯 在 碘 、 magnesium 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以82%的产率得到(2E)-3-(1-chloro-6-methoxy-3,4-dihydronaphthalen-2-yl)-1-(3,5-dimethoxyphenyl)prop-2-en-1-one
  参考文献：
  名称：

  Synthesis and study of the fluorescent behavior of 3-pyridinecarbonitriles

  摘要：

  A series of (2E)-3-(1-chloro-6-methoxy-3,4-dihydronaphthalen-2-yl)-1-(4-aryl)prop-2-en-1-ones (chalcones) have been synthesized by a new synthetic route. The 3-pyridinecarbonitrile derivatives were synthesized by the Michael reaction of malononitrile (in base) and aroylacetonitriles (in acid) with chalcones in one pot. The fluorescent properties and quantum yields of these compounds were studied.

  DOI：

  10.1007/s00706-009-0116-8
• 作为产物：
  描述：

  (2E)-3-(1-chloro-6-methoxy-3,4-dihydronaphthalen-2-yl)acrylic acid 、 二甲羟胺盐酸盐 在 N,N'-羰基二咪唑 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以89%的产率得到(2E)-3-(1-chloro-6-methoxy-3,4-dihydronaphthalen-2-yl)-N-methoxy-N-methylacrylamide
  参考文献：
  名称：

  Synthesis and study of the fluorescent behavior of 3-pyridinecarbonitriles

  摘要：

  A series of (2E)-3-(1-chloro-6-methoxy-3,4-dihydronaphthalen-2-yl)-1-(4-aryl)prop-2-en-1-ones (chalcones) have been synthesized by a new synthetic route. The 3-pyridinecarbonitrile derivatives were synthesized by the Michael reaction of malononitrile (in base) and aroylacetonitriles (in acid) with chalcones in one pot. The fluorescent properties and quantum yields of these compounds were studied.

  DOI：

  10.1007/s00706-009-0116-8

文献信息

• Synthesis and study of the fluorescent behavior of 3-pyridinecarbonitriles
  作者：Madhukar N. Jachak、Sandeep M. Bagul、Bhausaheb K. Ghotekar、Raghunath B. Toche

  DOI：10.1007/s00706-009-0116-8

  日期：2009.6

  A series of (2E)-3-(1-chloro-6-methoxy-3,4-dihydronaphthalen-2-yl)-1-(4-aryl)prop-2-en-1-ones (chalcones) have been synthesized by a new synthetic route. The 3-pyridinecarbonitrile derivatives were synthesized by the Michael reaction of malononitrile (in base) and aroylacetonitriles (in acid) with chalcones in one pot. The fluorescent properties and quantum yields of these compounds were studied.