2,7-difluoro-4,5-dimethoxyspiro (9H-fluorene-9,4'-imidazolidine)-2',5'-dione | 139911-05-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2,7-difluoro-4,5-dimethoxyspiro (9H-fluorene-9,4'-imidazolidine)-2',5'-dione
• 英文别名: 2,7-Difluoro-4,5-dimethoxyspiro-(9H-fluorene-9,4'-imidazoline)-2',5'-dione；2,7-difluoro-4,5-dimethoxyspiro[fluorene-9,5'-imidazolidine]-2',4'-dione
• CAS: 139911-05-0
• 化学式: C₁₇H₁₂F₂N₂O₄
• 分子量: 346.29
• InChiKey: OVRBKKLFIRJPKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Remedies for vertebral canal stenosis
  申请人：Takenobu Yoshifumi

  公开号：US20060058310A1

  公开（公告）日：2006-03-16

  The present invention relates to a preventive and/or therapeutic agent for spinal canal stenosis comprising aldose reductase inhibitory compounds. A representative example of aldose reductase inhibitory compounds is the compound represented by formula (I): wherein all the symbols represent the same meaning as described in the specification; a salt of its acid when R 3a represents hydrogen, or solvate thereof The therapeutic agent of the present invention is effective for prevention and/or therapy for spinal canal stenosis and the like, such as lumbar spinal canal stenosis.