3α,4β-dibromo-5β-cholestane | 2324-91-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3α,4β-dibromo-5β-cholestane
• 英文别名: 3α,4β-Dibrom-5β-cholestan；(3R,4R,5S,8S,9S,10R,13R,14S,17R)-3,4-dibromo-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene
• CAS: 2324-91-6
• 化学式: C₂₇H₄₆Br₂
• 分子量: 530.47
• InChiKey: MJONUVUVBROXRW-XHJWVSIOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.24
• 重原子数：
  29.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0.0
• 氢给体数：
  0.0
• 氢受体数：
  0.0

反应信息

• 作为产物：
  描述：

  粪甾烷-3-醇 在 氯仿 、 五溴化磷 、 calcium carbonate 作用下， 生成 3α,4β-dibromo-5β-cholestane
  参考文献：
  名称：

  Pace Length Effects in Human Walking: “Groucho” Gaits Revisited

  摘要：

  In the present study, the authors explored the effect of manipulating the distance between footfalls (pace length) in level walking in 3 men. The translational kinetic energy to gravitational potential energy (E-k-E-p) exchange was found to be maintained until pace length reached approximately 110% of single limb length. Beyond that pace length, the compliance of the support limb increased, apparently to allow the muscular absorption of excess kinetic energy. E-p oscillations decreased with increasing limb compliance, and the participants could control that relationship with pace length alone. The authors compared the present results with previous descriptions of the relationship between limb compliance and pace length in running. An analog of the running relationship holds for walking as well. The trigger for those gait modifications has not yet been identified, however. The present results have implications for the exploration of the integrated control of mechanical consequences in human locomotion and for understanding the walk-run transition in bipeds other than humans, such as ground-dwelling birds.

  DOI：

  10.1080/00222890209601949

文献信息

• Pace Length Effects in Human Walking: “Groucho” Gaits Revisited
  作者：John E. A. Bertram、Paul D'antonio、Jaime Pardo、David V. Lee

  DOI：10.1080/00222890209601949

  日期：2002.9

  In the present study, the authors explored the effect of manipulating the distance between footfalls (pace length) in level walking in 3 men. The translational kinetic energy to gravitational potential energy (E-k-E-p) exchange was found to be maintained until pace length reached approximately 110% of single limb length. Beyond that pace length, the compliance of the support limb increased, apparently to allow the muscular absorption of excess kinetic energy. E-p oscillations decreased with increasing limb compliance, and the participants could control that relationship with pace length alone. The authors compared the present results with previous descriptions of the relationship between limb compliance and pace length in running. An analog of the running relationship holds for walking as well. The trigger for those gait modifications has not yet been identified, however. The present results have implications for the exploration of the integrated control of mechanical consequences in human locomotion and for understanding the walk-run transition in bipeds other than humans, such as ground-dwelling birds.