N-Tetradecanoyltyramin | 21469-27-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N-Tetradecanoyltyramin
• 英文别名: Tetradecanoyl tyramine；N-[2-(4-hydroxyphenyl)ethyl]tetradecanamide
• CAS: 21469-27-2
• 化学式: C₂₂H₃₇NO₂
• 分子量: 347.541
• InChiKey: NYSVWRDQFBYCQI-UHFFFAOYSA-N

物化性质

• 沸点：
  535.1±33.0 °C(Predicted)
• 密度：
  0.971±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  25
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对羟基苯乙胺 、 肉豆蔻酰氯 在 吡啶 作用下， 生成 N-Tetradecanoyltyramin
  参考文献：
  名称：

  Sciortino; Du Ban, Bollettino Chimico Farmaceutico, 1968, vol. 107, # 8, p. 506 - 511

  摘要：

  DOI：

文献信息

• 一种对羟基苯乙胺类化合物及其制备方法和用途
  申请人：北京中医药大学

  公开号：CN114605279A

  公开（公告）日：2022-06-10

  本发明提供一种对羟基苯乙胺类化合物及其制备方法和应用。本发明所述对羟基苯乙胺类化合物具有显著激活酪氨酸酶的作用，此外该化合物还具有抑制肿瘤细胞和血管增生的效果。
• Antiplasmodial Metabolites Isolated from the Marine Octocoral <i>Muricea austera</i>
  作者：Marcelino Gutiérrez、Todd L. Capson、Héctor M. Guzmán、José González、Eduardo Ortega-Barría、Emilio Quiñoá、Ricardo Riguera

  DOI：10.1021/np060007f

  日期：2006.10.1

  Bioassay-guided fractionation of the MeOH extract from the octocoral Muricea austera collected in the Pacific coast of Panama led to the isolation of eight compounds, including three tyramine derivatives (1-3), two steroidal pregnane glycosides ( 4, 5), and three sesquiterpenoids (6-8). Compounds 2-5 are new natural products, and their structures were determined on the basis of their spectroscopic data (HRMS, 1D and 2D NMR, and CD studies). The antiprotozoal activities of the natural compounds 1-8 as well as those of a series of synthetic glycosides (11-22) and tyramine derivatives (23-35) were evaluated in vitro against a drug-resistant Plasmodium falciparum and intracellular form of Trypanosoma cruzi.
• Differential scanning calorimetric studies on the thermotropic phase behavior of dry and hydrated forms of N-acyltyramines
  作者：Stevenson Priscilla、D. Sivaramakrishna、Veerappan Anbazhagan

  DOI：10.1016/j.tca.2014.03.030

  日期：2014.6

  In this paper, a homologous series of N-acyltyramine (NATA) - which is biosynthetic precursor for neuroactive lipids, N-acyldopamine - have been synthesized and their thermotropic phase transitions were characterized by differential scanning calorimetry (DSC). NATA undergoes a major sharp endothermic transition with the melting point of the hydrated samples occurs considerably at lower temperature compared to the dry samples. Thermodynamic parameters, transition enthalpy (Delta H-t) and transition entropy (Delta S-t), associated with the chain-melting phase transitions depends linearly on the number of carbon atoms. The contributions of each methylene unit to the transition enthalpy and entropy and the end contributions arising from the head group and the terminal group was determined and reported. These results are very important to understand the thermodynamics basis of NATA phase properties in other membrane lipids. (C) 2014 Elsevier B.V. All rights reserved.