2-(β-naphthoxymethyl)benzimidazole | 100804-66-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-(β-naphthoxymethyl)benzimidazole
• 英文别名: 2-[(naphthalene-2-yloxy)methyl]-1H-benzimidazole；2-(2-naphthoxymethyl)benzimidazole；2-(naphthalen-2-yloxymethyl)-1H-benzimidazole
• CAS: 100804-66-8
• 化学式: C₁₈H₁₄N₂O
• mdl: MFCD00856329
• 分子量: 274.322
• InChiKey: IOENYQZRXBUTBA-UHFFFAOYSA-N

物化性质

• 沸点：
  555.3±33.0 °C(Predicted)
• 密度：
  1.282±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  37.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(β-naphthoxymethyl)benzimidazole 在 sodium hydroxide 、 磷酸 、 phosphorus pentoxide 、 三氯氧磷 作用下， 反应 6.0h， 生成 2-benzo[e][1]benzofuran-2-yl-1H-benzimidazole
  参考文献：
  名称：

  Shekar, P. C.; Seshadri, S., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1985, vol. 24, p. 477 - 480

  摘要：

  DOI：
• 作为产物：
  描述：

  2-萘氧乙酸 、 邻苯二胺 在 硼酸 作用下， 以 乙二醇 为溶剂， 以89%的产率得到2-(β-naphthoxymethyl)benzimidazole
  参考文献：
  名称：

  Shekar, P. C.; Seshadri, S., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1985, vol. 24, p. 477 - 480

  摘要：

  DOI：

文献信息

• Composition For the Vapor Phase Dehydrohalogenation of 1,1,2-Trihaloethane To 1,1-Dihaloethylene and Methods For Preparing and Using Such Composition
  申请人：Serhuchev Yurii Oleksiyovych

  公开号：US20080242902A1

  公开（公告）日：2008-10-02

  Described are compositions adapted to catalyze the vapor phase dehydrohalogenation of 1,1,2-trihaloethane to 1,1-dihaloethylene, e.g., 1,1,2-trichloroethane to vinylidene chloride. These materials include activated carbon and at least one benzimidazole-containing material defined herein as including benzimidazole, a derivative thereof, a salt thereof or mixtures thereof. Also described are methods for producing and using these catalytic compositions.

  描述了适用于催化1,1,2-三卤乙烷蒸汽相脱卤反应的组合物，例如1,1,2-三氯乙烷转化为二氯乙烯，例如，1,1,2-三氯乙烷转化为氯乙烯。这些材料包括活性炭和至少一种苯并咪唑含有物质，本文中定义为包括苯并咪唑、其衍生物、其盐或其混合物。还描述了制备和使用这些催化组合物的方法。
• Synthesis, antibacterial and anticancer evaluation of 5-substituted (1,3,4-oxadiazol-2-yl)quinoline
  作者：Salahuddin、Avijit Mazumder、Mohammad Shaharyar

  DOI：10.1007/s00044-014-1308-2

  日期：2015.6

  2-Chloroquinoline-3-carbaldehyde (2) was synthesized via Vilsmeier-Haack method using acetanilide. Phenoxy/naphthalene-1-yl/naphthalen-2-yloxy methyl-1H-benzimidazol-1-yl)acetohydrazide (7a-c) were synthesized using 2-[2-(phenoxy/naphthalen-1-yl/naphthalen-2-yloxy methyl)-1H-benzimidazol-1-yl]acetohydrazide (6a-c). The title compounds 2-chloro-3-5-[(2-phenoxy/naphthalene-1-yl/naphthalen-2-yloxy methyl-1-H-benzimidazol-1-yl)methyl]-1,3,4-oxadiazol-2-yl}quinolone (8a-c) were prepared using chloramine-T. In the second series, (2-chloroquinolin-3-yl)methylidene]-substituted benzohydrazide (11a-i) were prepared by the reaction of 2-chloroquinoline-3-carbaldehyde (2) and an acid hydrazide (10a-i). The synthesized compounds were characterized by IR, NMR, Mass spectrometry, elemental analysis and screened for their antibacterial (serial dilution technique and disc diffusion method) and anticancer activity by NCI 60 cell screen at a single high dose (10(-5) M) on various panel/cell lines. The synthesized compounds (8a, 8c, 12a, 12b, 12c and 12h) were acting as a magic bullet against gram-positive strains of Bacillus cereus MTCC1305, and the compounds (12a, 12c and 12h) were also found to be extremely active against Klebsiella pneumonia NCTC7447. In the in vitro screen on tested cancer cell line, the compound (12d) showed 95.70 growth percent (GP) and highly active on SNB-75 (CNS cancer) and UO-31 (renal cancer) (GP = 53.35 and 64.35, respectively), and the compound (8a) showed 96.86 GP and highly active on SNB-75 (CNS cancer GP 51.27).
• SHEKAR, P. C.;SESHADRI, S., INDIAN J. CHEM., 1985, 24, N 5, 477-480
  作者：SHEKAR, P. C.、SESHADRI, S.

  DOI：——

  日期：——
• US7470827B2
  申请人：——

  公开号：US7470827B2

  公开（公告）日：2008-12-30
• [EN] COMPOSITION FOR THE VAPOR PHASE DEHYDROHALOGENATION OF 1,1,2-TRIHALOETHANE TO 1,1-DIHALOETHYLENE AND METHODS FOR PREPARING AND USING SUCH COMPOSITIONS<br/>[FR] PREPARATION POUR LA DESHYDROHALOGENATION EN PHASE VAPEUR DE 1,1,2-TRIHALOGENOETHANE EN 1,1-DIHALOGENOETHYLENE ET PROCEDES D'ELABORATION ET D'EMPLOI DE TELLES PREPARATIONS
  申请人：PPG IND OHIO INC

  公开号：WO2006132625A1

  公开（公告）日：2006-12-14

  [EN] Described are compositions adapted to catalyze the vapor phase dehydrohalogenation of 1,1,2-trihaloethane to 1,1-dihaloethylene, e.g., 1,1,2-trichloroethane to vinylidene chloride. These materials include activated carbon and at least one benzimidazole-containing material defined herein as including benzimidazole, a derivative thereof, a salt thereof or mixtures thereof. Also described are methods for producing and using these catalytic compositions.
  [FR] La présente invention concerne des préparations adaptées à la catalyse de la déshydrohalogénation en phase vapeur de 1,1,2-trihalogénoéthane en 1,1-dihalogénoéthylène, par exemple de 1,1,2-trichloroéthane en chlorure de vinylidène. Ces matériaux incluent du charbon actif et au moins un matériau contenant du benzimidazole, défini dans la présente invention comme incluant le benzimidazole, un dérivé de benzimidazole, un sel de benzimidazole ou des mélanges de ces substances. La présente invention concerne également des procédés d'élaboration et d'emploi de telles préparations catalytiques.