1-acetyl piperidine-4-carbonyl chloride hydrochloride | 95037-48-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-acetyl piperidine-4-carbonyl chloride hydrochloride
• 英文别名: 1-acetyl-piperidine-4-carbonyl chloride hydrochloride；1-acetylpiperidine-4-carbonyl chloride hydrochloride；1-acetylpiperidine-4-carbonylchloride hydrochloride；1-acetylpiperidne-4-carbonylchloride hydrochloride；1-acetylpiperidine-4-carbonyl chloride;hydrochloride
• CAS: 95037-48-2
• 化学式: C₈H₁₂ClNO₂*ClH
• 分子量: 226.103
• InChiKey: MVINXGMMFYXGDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.43
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  37.4
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 安全说明：
  S26,S36/37/39,S45
• 危险类别码：
  R34

反应信息

• 作为反应物：
  描述：

  1-acetyl piperidine-4-carbonyl chloride hydrochloride 、 5-[(4-羟基苯基)磺酰基]-噻吩-2-磺酰胺 在 三乙胺 作用下， 以 乙酸乙酯 、 1,2-二氯乙烷 、 丙酮 为溶剂， 生成 4-[(2-Sulfamoyl-5-thienyl)sulfonyl]phenyl 1-acetylpiperidine-4-carboxylate
  参考文献：
  名称：

  Acyloxy derivatives of [phenylsulfonyl(or sulfinyl)]thiophenesulfonamide

  摘要：

  新颖的苯磺酰（或亚磺酰）基硫代磺酰胺的酰氧衍生物对于眼科配方中用于局部治疗提高眼内压的药物非常有用，包括眼用滴剂和插入剂。

  公开号：

  US04477466A1

文献信息

• Protein-tyrosine phosphatase inhibitors and uses thereof
  申请人：——

  公开号：US20040214870A1

  公开（公告）日：2004-10-28

  The present invention is directed to compounds of formula (I), 1 or a pharmaceutically suitable salt or prodrug thereof, which are useful for the selective inhibition of protein tyrosine phosphatase-1B (PTP1B), and are useful for the treatment of disorders caused by overexpressed or altered protein tyrosine phosphatase 1B.

  本发明涉及式(I)的化合物，或其药用适宜盐或前药，用于选择性抑制蛋白酪氨酸磷酸酶-1B（PTP1B），并且用于治疗由过度表达或改变的蛋白酪氨酸磷酸酶1B引起的疾病。
• 2-ALKYLBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS
  申请人：Yang Zhicai

  公开号：US20080214601A1

  公开（公告）日：2008-09-04

  Compounds of formulae I and II: are disclosed as 5-HT 3 inhibitors. Those compounds are useful in treating CINV, IBS-D and other diseases and conditions.

  化合物I和II的化学式：被披露为5-HT3受体拮抗剂。这些化合物在治疗化疗诱发恶心和呕吐（CINV）、腹泻型肠易激综合征（IBS-D）和其他疾病和症状中很有用。
• [EN] COMPOUND LIBRARIES OF N-(AMINOCARBONYL)-PIPERIDINE-4-CARBOXAMIDE DERIVATIVES CAPABLE OF BINDING TO G-PROTEIN COUPLED RECEPTORS<br/>[FR] BANQUE DE COMPOSES CONTENANT DES DERIVES DE N-(AMINOCARBONYL)-PIPERIDINE-4-CARBOXAMIDE, CAPABLES DE SE FIXER AUX RECEPTEURS COUPLES A LA PROTEINE G
  申请人：BIOFOCUS PLC

  公开号：WO2004058259A1

  公开（公告）日：2004-07-15

  The present invention provides a compound library targeted to receptors with a requirement for a positively charged amine in their structure activity relationships. It is designed to produce both agonists and antagonists and so is expected to be especially useful in producing ligands for orphan receptors. The library is designed around an acylurea coupled to a piperidine moiety. A combination of specific motifs R2 and R1 are appended from the central scaffold and are designed to pick up different interactions at a receptor site. The library comprises or consists of a set of structurally related compounds of general formula (I).

  本发明提供了一个针对需要带正电胺基的受体的化合物库，该化合物库旨在产生激动剂和拮抗剂，因此预计在制备孤儿受体的配体方面特别有用。该库围绕一个酰基脲偶联到哌啶基团而设计。从中心支架附加特定基团R2和R1的组合被设计为在受体位点捕获不同的相互作用。该库包括或由一组结构相关的通用式(I)化合物组成。
• 5,6-dihydro-4H-imidazo[4,5,1-ij]quinolines
  申请人：Hoechst-Roussel Pharmaceuticals Inc.

  公开号：US05500423A1

  公开（公告）日：1996-03-19

  Novel 5,6-dihydro-4H-imidazo[4,5,1-ij]quinolines, intermediates and processes for the preparation thereof, and methods for alleviating pain utilizing compounds or compositions thereof are disclosed.

  揭示了新型5,6-二氢-4H-咪唑并[4,5,1-ij]喹啉、其中间体和制备方法，以及利用化合物或其组合物缓解疼痛的方法。
• Piperidineacetic acid derivatives useful as fibrinogen antagonist agent
  申请人：Glaxo Group Limited

  公开号：US05861414A1

  公开（公告）日：1999-01-19

  The invention provides the compounds of formula (I) ##STR1## and pharmaceutically acceptable derivatives thereof, in which: X represents either CH.sub.2 --CH.sub.2 or CH.dbd.CH, and Y represents a hydrogen atom or a phenylmethyl group, wherein the phenyl group is optionally substituted by one or more halogen atoms. Compounds of formula (I) inhibit blood platelet aggregation.

  该发明提供了式（I）的化合物及其药用可接受的衍生物，其中：X代表CH₂-CH₂或CH=CH，Y代表氢原子或苯甲基基团，其中苯基可能被一个或多个卤原子取代。式（I）的化合物抑制血小板聚集。