hexadecyltrimethylammonium dodecylsulfate | 38844-00-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: hexadecyltrimethylammonium dodecylsulfate
• 英文别名: 1-Hexadecanaminium, N,N,N-trimethyl-, dodecyl sulfate (1:1)；dodecyl sulfate;hexadecyl(trimethyl)azanium
• CAS: 38844-00-7
• 化学式: C₁₂H₂₅O₄S*C₁₉H₄₂N
• 分子量: 549.943
• InChiKey: MTMVHVOXBMPHIQ-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  9.56
• 重原子数：
  37
• 可旋转键数：
  26
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  十六烷基三甲基溴化铵 、 sodium dodecyl-sulfate 以 水 为溶剂， 生成 hexadecyltrimethylammonium dodecylsulfate
  参考文献：
  名称：

  A novel catanionic surfactant: Hexadecyltrimethylammonium dodecyl sulfate

  摘要：

  AbstractThe novel catanionic surfactant, hexadecyltrimethylammonium dodecyl sulfate, was prepared from the equimolar aqueous solutions of cationic, hexadecyltrimethylammonium bromide, and anionic, sodium dodecyl sulfate, surfactants. The composition, structure, morphology and thermal behavior of new compound were determined by chemical, X‐ray diffraction, IR and 1H NMR spectra analyses, differential scanning calorimetry, thermogravimetry and polarizing microscopy.The thermal behavior of solid crystalline CTADS is rather complex because of its polymorphism, thermotropic mesomorphism and coexistence of ordered and disordered phases below the melting temperature. There are two parallel mechanisms during heating: structural transition of the system and transition from solid crystalline to liquid crystalline phase.Several polymorphic phases, all of the bilayered structure, were observed exhibiting a change of the basic lamellar thickness with temperature. Polarizing microscopy revealed a characteristic texture of the smectic phase.

  DOI：

  10.1002/bbpc.19971011222

文献信息

• Surfactant sensing electrode for potentiometric titrations
  申请人：The Clorox Company

  公开号：EP0382958A1

  公开（公告）日：1990-08-22

  A coated-wire (11) electrode for potentiometrically titrating surfactant molecules having more than ten carbon atoms includes an electrically-conductive core (31) coated with a semipermeable membrane (35). The membrane matrix includes a polymer, a plasticizer and an ion-exchange material consisting essentially of dimidium bromide-disulphine blue in suitable proportions to be surfactant selective. The membrane is responsive to anionic, cationic and amphoteric surfactants as well as alkoxylated nonionic surfactants.

  用于电位滴定具有十个以上碳原子的表面活性剂分子的涂膜丝（11）电极包括一个涂有半透膜（35）的导电芯（31）。膜基质包括聚合物、增塑剂和离子交换材料，离子交换材料主要由溴化二脒-二硫化钼蓝组成，比例适当，具有表面活性剂选择性。该膜对阴离子、阳离子和两性表面活性剂以及烷氧基化非离子表面活性剂均有反应。
• Exploring the dual impact of hydrocarbon chainlength and the role of piroxicam a conventional NSAID on soylecithin/ion pair amphiphiles mediated hybrid vesicles for brain – tumor targeted drug delivery
  作者：Pritam Guha、Biplab Roy、Prasant Nahak、Gourab Karmakar、Chien H. Chang、Alexey G. Bikov、Alexander B. Akentiev、Boris A. Noskov、Amit K. Mandal、Anoop Kumar、P.A. Hassan、V.K. Aswal、Takeshi Misono、Kanjiro Torigoe、Amiya K. Panda

  DOI：10.1016/j.colsurfa.2018.03.025

  日期：2018.6

  Development of drug delivery systems, not the drug discovery, has become more cynosures towards the efficacy of drug against the target cells. Modified hybrid cationic vesicles (HCV) were formulated using soylecithin (SLC), ion pair amphiphile (IPA, hexadecyltrimethylammonium-dodecylsulfate, HTMA(+)-DS-), bi-tail cationic surfactant dialkyldimethylammonium bromides (DXDABs, bis-C-12 to C-18) and cholesterol. Piroxicam (Px), a conventional non steroidal anti inflamatory drug (NSAID), with potent yet unexplored anticancer activity, was encapsulated in the hybrid vesicles. Dual impact of DXDABs and Px on SLC/IPA were scrutinized in the form of monolayer, bilayer and solid supported bilayer. Favourable hydrophobic inteaction between SLC/IPA and dihexadecyldimethylammonium bromide (DHDAB) as well as the intercalation of Px molecules between the amphiphiles were noticed through the surface pressure area measuremnts. Vesicles without and with Px were fairly monodisperse with positive zeta potential (Z. P.) and considerably stable upto two months. Size of the vesicles enhanced with Px incorporation. Vesicles maintain spherical morphology as revealed from the electronic microscopic studies. Differential scanning calaorimetry and FTIR studies confirm the location of Px membrane palisade that enhances the extent of hydration by increasing the proportion of H-bonding. Bilayer thickness and the spacing between two adjecent lamellar phase were investigated by combined small angle neutron scattering and small angle X-ray scattering. Atomic force microscopic studies confirm the Px induced fluidization of membrane bilayer. The entrapment efficiency of vesicles to host Px depends on the amount of IPA present in the bilayer. Px hosted cationic vesicles showed less than 2% hemolysis. The drug reigned supreme over human neuroblastoma cell line (SH-SY 5Y) when encapsulated inside the membrane and was non toxic to normal human blood cell lymphocyte (PBMC) as revealed from cytotoxicity assay.
• LIQUID CRYSTAL COMPOUNDS
  申请人：THE UNIVERSITY OF SHEFFIELD

  公开号：EP0252925A1

  公开（公告）日：1988-01-20
• US4810331A
  申请人：——

  公开号：US4810331A

  公开（公告）日：1989-03-07
• US4948473A
  申请人：——

  公开号：US4948473A

  公开（公告）日：1990-08-14