(2-ethoxy-ethyl)-bis-(2-hydroxy-ethyl)-amine | 109142-30-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (2-ethoxy-ethyl)-bis-(2-hydroxy-ethyl)-amine
• 英文别名: (2-Aethoxy-aethyl)-bis-(2-hydroxy-aethyl)-amin；N-ethoxyethyl-N,N-diethanolamine；2,2'-[(2-Ethoxyethyl)azanediyl]diethanol；2-[2-ethoxyethyl(2-hydroxyethyl)amino]ethanol
• CAS: 109142-30-5
• 化学式: C₈H₁₉NO₃
• mdl: MFCD16152299
• 分子量: 177.244
• InChiKey: SEQKLFDHGFSUHZ-UHFFFAOYSA-N

物化性质

• 保留指数：
  1386

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  12
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (2-ethoxy-ethyl)-bis-(2-hydroxy-ethyl)-amine 在 吡啶 、 氯化亚砜 作用下， 以58%的产率得到(2-ethoxy-ethyl)-bis-(2-chloro-ethyl)-amine
  参考文献：
  名称：

  INTERMEDIATE COMPOUND OF TECHNETIUM NITRIDE COMPLEX FOR RADIODIAGNOSTIC IMAGING

  摘要：

  一种由以下化学式（I）表示的双膦氨基化合物：其中R1、R2、R3、R4和R5分别是具有1至6个碳原子的烷基基团，n是1至6的整数，作为制备用于放射诊断成像的锝氮化物配合物的中间体非常有用。

  公开号：

  US20100160615A1
• 作为产物：
  描述：

  bis-(2-hydroxy-ethyl)-(2-vinyloxy-ethyl)-amine 在 镍 作用下， 生成 (2-ethoxy-ethyl)-bis-(2-hydroxy-ethyl)-amine
  参考文献：
  名称：

  Schostakowskii; Tschekulaewa, Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1954, p. 1111,1115;engl.Ausg.S.971,974

  摘要：

  DOI：

文献信息

• Diarylamine-Containing Compounds and Compositions, and their use as Modulators of C-Kit Receptors
  申请人：Molteni Valentina

  公开号：US20070149538A1

  公开（公告）日：2007-06-28

  Described herein are compounds that include a diarylamine structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of c-kit receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent and/or inhibit and/or ameliorate the pathology and/or symptomology diseases or conditions associated with the activity of c-kit receptors.

  本文描述了包含二芳胺结构特征的化合物。还描述了制备这种化合物的方法，使用这种化合物调节c-kit受体活性的方法，以及包含这种化合物的药物组合物和药物。本文还描述了使用这种化合物、药物组合物和药物治疗和/或预防和/或抑制和/或改善与c-kit受体活性相关的病理学和/或症状学疾病或状况的方法。
• Sakurai; Izumi, Pharmaceutical Bulletin, 1953, vol. 1, p. 297,300
  作者：Sakurai、Izumi

  DOI：——

  日期：——
• WO2007/83395
  申请人：——

  公开号：——

  公开（公告）日：——
• Six-Membered Metalla-coronands. Synthesis and Crystal Packing:  Columns, Compartments, and 3D-Networks^,
  作者：Rolf W. Saalfrank、Christian Deutscher、Stefan Sperner、Takayuki Nakajima、Ayuk M. Ako、Eveline Uller、Frank Hampel、Frank W. Heinemann

  DOI：10.1021/ic049799w

  日期：2004.7.1

  Reaction of various N-substituted diethanolamines H2L3 (4) with calcium hydride and iron(III) chloride leads to the self-assembly of six-membered ferric wheels [Fe6X6(L-3)(6)] (5). Principally, all the iron coronands are isostructural; however, they differ fundamentally with respect to their crystal packing. Exemplarily, this is discussed for selected members of the space groups R(3)over bar, P(3)over bar, P2(1)/c, P2(1)/n, C2/c, and P(1)over bar. Depending on the nature of their sidearms, the ferric wheels create various substructures. For instance, the ferric wheels 5a-i of space group R(3)over bar or P(3)over bar are piled in parallel in cylindrical columns, which are surrounded by six parallel columns alternately dislocated by 1/3c and 2/3 c against the central one. Pronounced van der Waals interactions give rise to compartmentation and incarceration of guest molecules as seen for 5e,g. However, in 5h strong pi-pi interactions create a three-dimensional scaffold, The most significant difference of the ferric wheels 5j-p of space groups P2(1)/c, P2(1/)n, and C2/c is that these ferric wheels are arranged in parallel in two orientations. They differ mainly only by the included angle of the two groups of parallel wheels. In the case of 51, molecular chains are formed in the crystal due to pi-pi interactions. The ferric wheels 5q-y of space group P(1)over bar are packed in the crystal most simply, with all the ferric wheels piled in parallel.
• WU CHENGTAI; SONG JAINGAO, J. WUHAN UNIV. (NATUR. SCI. ED.),(1986) N 2, 65-70
  作者：WU CHENGTAI、 SONG JAINGAO

  DOI：——

  日期：——