(E)-3-Dimethylamino-2-naphthalen-1-yl-propenal | 105492-01-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (E)-3-Dimethylamino-2-naphthalen-1-yl-propenal
• 英文别名: 3-(Dimethylamino)-2-naphthalen-1-ylprop-2-enal；3-(dimethylamino)-2-naphthalen-1-ylprop-2-enal
• CAS: 105492-01-1
• 化学式: C₁₅H₁₅NO
• 分子量: 225.29
• InChiKey: SVDCJIZJYUCFNL-UHFFFAOYSA-N

物化性质

• 熔点：
  108-110 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• 沸点：
  489.2±34.0 °C(Predicted)
• 密度：
  1.096±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (E)-3-Dimethylamino-2-naphthalen-1-yl-propenal 在 sodium hydroxide 、 氯化亚砜 作用下， 以 乙醇 、 二氯甲烷 、 水 为溶剂， 反应 1.08h， 生成 2-(1-naphthyl)-3-chloroacrolein
  参考文献：
  名称：

  Design, synthesis, and antifungal activity of inhibitors of brassilexin detoxification in the plant pathogenic fungus Leptosphaeria maculans

  摘要：

  Potential inhibitors of Leptosphaeria maculans mediated detoxification of the phytoalexin brassilexin were designed and synthesized based on the planar heteroaromatic structure of isothiazolo[5,4-b]indole. Screening of these compounds for inhibition of brassilexin detoxification in cultures of L. maculans indicated that 4-(2-chlorophenyl)isothiazole had the largest effect on the rate of brassilexin detoxification. However, the most antifungal compound among the potential inhibitors, isothiazolo[5,4-b]quinoline, did not appear to affect the metabolism of brassilexin noticeably, suggesting that growth inhibition is not sufficient to slow down the rate of brassilexin detoxification. Furthermore, it was determined that 4-arylisothiazoles as well as isothiazolo[5,4-b]thianaphthene displayed antifungal activity against L. maculans. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2005.08.053
• 作为产物：
  描述：

  1-萘乙酸 、 N,N-二甲基甲酰胺 在 三氯氧磷 作用下， 反应 4.0h， 以66%的产率得到(E)-3-Dimethylamino-2-naphthalen-1-yl-propenal
  参考文献：
  名称：

  Padmanabhan, S.; Seshadri, S., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1985, vol. 24, p. 1111 - 1114

  摘要：

  DOI：

文献信息

• Padmanabhan, S.; Seshadri, S., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1985, vol. 24, p. 1111 - 1114
  作者：Padmanabhan, S.、Seshadri, S.

  DOI：——

  日期：——
• Design, synthesis, and antifungal activity of inhibitors of brassilexin detoxification in the plant pathogenic fungus Leptosphaeria maculans
  作者：M. Soledade. C. Pedras、Mojmir Suchy

  DOI：10.1016/j.bmc.2005.08.053

  日期：2006.2

  Potential inhibitors of Leptosphaeria maculans mediated detoxification of the phytoalexin brassilexin were designed and synthesized based on the planar heteroaromatic structure of isothiazolo[5,4-b]indole. Screening of these compounds for inhibition of brassilexin detoxification in cultures of L. maculans indicated that 4-(2-chlorophenyl)isothiazole had the largest effect on the rate of brassilexin detoxification. However, the most antifungal compound among the potential inhibitors, isothiazolo[5,4-b]quinoline, did not appear to affect the metabolism of brassilexin noticeably, suggesting that growth inhibition is not sufficient to slow down the rate of brassilexin detoxification. Furthermore, it was determined that 4-arylisothiazoles as well as isothiazolo[5,4-b]thianaphthene displayed antifungal activity against L. maculans. (c) 2005 Elsevier Ltd. All rights reserved.