2-amino-5-(4-hydroxy-3-methoxy-benzylidene)-1-methyl-1,5-dihydro-imidazol-4-one | 29974-40-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-amino-5-(4-hydroxy-3-methoxy-benzylidene)-1-methyl-1,5-dihydro-imidazol-4-one
• 英文别名: 2-amino-1-methyl-5-vanillylidene-1,5-dihydro-imidazol-4-one；2-Amino-1-methyl-5-vanillyliden-1,5-dihydro-imidazol-4-on；(5E)-2-amino-5-[(4-hydroxy-3-methoxyphenyl)methylidene]-1-methylimidazol-4-one
• CAS: 29974-40-1
• 化学式: C₁₂H₁₃N₃O₃
• 分子量: 247.254
• InChiKey: ZIAJUNWHJUKVDF-VMPITWQZSA-N

物化性质

• 沸点：
  429.0±55.0 °C(Predicted)
• 密度：
  1.37±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  88.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-amino-5-(4-hydroxy-3-methoxy-benzylidene)-1-methyl-1,5-dihydro-imidazol-4-one 在 sodium amalgam 、 水 作用下， 生成 2-amino-1-methyl-5-vanillyl-1,5-dihydro-imidazol-4-one
  参考文献：
  名称：

  Deulofeu; Guerrero, Organic Syntheses, 1955, vol. III, p. 586

  摘要：

  DOI：
• 作为产物：
  描述：

  肌酸酐 、 香草醛 生成 2-amino-5-(4-hydroxy-3-methoxy-benzylidene)-1-methyl-1,5-dihydro-imidazol-4-one
  参考文献：
  名称：

  Richardson; Welch; Calvert, Journal of the American Chemical Society, 1929, vol. 51, p. 3077

  摘要：

  DOI：

文献信息

• NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREFOR
  申请人：Chung Hae Young

  公开号：US20140023603A1

  公开（公告）日：2014-01-23

  Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

  提供了一种具有美白皮肤、抗氧化和PPAR活性的新化合物及其医疗用途，该化合物具有美白皮肤的活性，可抑制酪氨酸酶，因此适用于用于美白皮肤的药物组合物或化妆品；具有抗氧化活性，因此适用于预防和治疗皮肤老化；具有PPAR活性，特别是PPARα和PPARγ活性，因此适用于用于预防和治疗肥胖、代谢性疾病或心血管疾病的药物组合物或保健食品。
• NOVEL COMPOUND HAVING SKIN-WHITENING, ANTI-OXIDIZING AND PPAR ACTIVITIES AND MEDICAL USE THEREOF
  申请人：Pusan National University Industry-University Cooperation Foundation

  公开号：US20160102065A1

  公开（公告）日：2016-04-14

  Provided are a novel compound having skin-whitening, anti-oxidizing and PPAR activities and a medical use thereof, and the compound has skin-whitening activities for the suppression of tyrosinase, and accordingly, is useful for use in skin-whitening pharmaceutical composition or cosmetic products; has anti-oxidant activities, and accordingly, is useful for the prevention and treatment of skin-aging; and has PPAR activities, and in particular, PPARα and PPARγ activities, and accordingly, is useful for use in pharmaceutical compositions or health foods which are effective for the prevention and treatment of obesity, metabolic disease, or cardiovascular disease.

  提供了一种具有美白、抗氧化和PPAR活性的新化合物及其医疗用途。该化合物具有抑制酪氨酸酶的美白活性，因此可用于美白药物组合物或化妆品产品；具有抗氧化活性，因此可用于预防和治疗皮肤老化；具有PPAR活性，特别是PPARα和PPARγ活性，因此可用于有效预防和治疗肥胖症、代谢疾病或心血管疾病的药物组合物或保健食品。
• Deulofeu; Guerrero, Organic Syntheses, 1942, vol. 22, p. 90
  作者：Deulofeu、Guerrero

  DOI：——

  日期：——
• US9216148B2
  申请人：——

  公开号：US9216148B2

  公开（公告）日：2015-12-22
• US9896421B2
  申请人：——

  公开号：US9896421B2

  公开（公告）日：2018-02-20