2'-naphthyl prop-1-(E/Z)-enyl ether | 831-27-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2'-naphthyl prop-1-(E/Z)-enyl ether
• 英文别名: 2-[(Prop-1-en-1-yl)oxy]naphthalene；2-prop-1-enoxynaphthalene
• CAS: 831-27-6
• 化学式: C₁₃H₁₂O
• 分子量: 184.238
• InChiKey: DNZAQZUAZGOLIZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-(allyloxy)naphthalene 在 potassium tert-butylate 作用下， 以 二甲基亚砜 为溶剂， 以94%的产率得到2'-naphthyl prop-1-(E/Z)-enyl ether
  参考文献：
  名称：

  A study of catalysed Wacker reaction for the deprotection of prop-2-enyl and prop-1-enyl ethers

  摘要：

  Pd(II)Cl-2 (1 mole equivalent)/CuCl/DMF-H2O/O-2/2h catalysed oxidation of various prop-2-enyl ethers 1a-12a is reported to result in the formation of Wacker ketones 1b,3b,5b,6b,9b,11b,12b (12-51%), hydrolysis products 2c,4c-7c,9c-12c (12-43%) and eta(2)-vinyl complexes of palladium chloride 2d,4d,7d,8d (52-94%) respectively. The corresponding prop-1-enyl ethers 2e,4e-12e under similar conditions react with a catalytic amount of Pd(II)Cl-2 (0.2 mole equivalent) rapidly (15-20 min.) to give exclusively hydroxy compounds 2c,4c-12c respectively in good yields (75-97%). (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)10198-3

文献信息

• Method for Preparing of Organofluoro Compounds in Alcohol Solvents
  申请人：Moon Dae Hyuk

  公开号：US20080171863A1

  公开（公告）日：2008-07-17

  The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of organofluoro compound by reacting fluorine salt containing radioactive isotope fluorine-18 with alkyl halide or alkyl sulfonate in the presence of alcohol of Chemistry (FIG. 1 ) as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.

  本发明涉及一种制备含有放射性同位素氟-18的有机氟化合物的方法。更具体地，本发明涉及一种通过在化学品（图1）的醇溶剂存在下，将含有放射性同位素氟-18的氟盐与烷基卤或烷基磺酸盐反应，以获得高产率的有机氟化合物的方法。根据本发明的合成反应可以在温和的条件下进行，以获得高产率的有机氟化合物，并且反应时间缩短，因此适用于有机氟化合物的大规模生产。
• METHOD FOR PREPARATION OF ORGANOFLUORO COMPOUNDS IN ALCOHOL SOLVENTS
  申请人：MOON Dae Hyuk

  公开号：US20100113763A1

  公开（公告）日：2010-05-06

  The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine-18. More particularly, the present invention relates to a method for preparation of organofluoro compound [ 18 F]florbetaben or [ 18 F]AV-45 having and , respectively, by reacting fluorine salt containing radioactive isotope fluorine-18 with alkyl halide or alkyl sulfonate in the presence of alcohol of Chemistry Formula 1 as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.

  本发明涉及一种制备含放射性同位素氟-18的有机氟化合物的方法。更具体地说，本发明涉及一种通过在化学式1的醇溶剂存在下，将含放射性同位素氟-18的氟盐与烷基卤化物或烷基磺酸酯反应，以获得高产率的有机氟化合物[18F] florbetaben或[18F] AV-45的方法，其化学式分别为11和12。根据本发明的合成反应可以在温和的条件下进行，以获得高产率的有机氟化合物，并且反应时间缩短，因此适用于有机氟化合物的大规模生产。
• Photolyses of (3-naphthoxypropyl)-, (4-naphthylbutyl)-, and (4-naphthyl-4-oxobutyl)cobaloxime
  作者：Masaru Tada、Mitsunori Hiratsuka、Hiroyuki Goto

  DOI：10.1021/jo00301a030

  日期：1990.7
• US7847092B2
  申请人：——

  公开号：US7847092B2

  公开（公告）日：2010-12-07
• [EN] METHOD FOR PREPARATION OF ORGANOFLUORO COMPOUNDS IN ALCOHOL SOLVENTS<br/>[FR] PROCEDE POUR LA PREPARATION DE COMPOSES ORGANOFLUORES DANS DES SOLVANTS ALCOOLIQUES
  申请人：FUTURECHEM CO LTD

  公开号：WO2006065038A1

  公开（公告）日：2006-06-22

  [EN] The present invention relates to a method for preparation of organofluoro compounds containing radioactive isotope fluorine- 18. More particularly, the present invention relates to a method for preparation of organofluoro compound by reacting fluorine salt containing radioactive isotope fluorine- 18 with alkyl halide or alkyl sulfonate in the presence of alcohol of Chemistry (Figure 1) as a solvent to obtain high yield of organofluoro compound. Synthesis reaction according to the present invention may be carried out under mild condition to give high yield of the organofluoro compounds and the reaction time is decreased, and thereby is suitable for the mass production of the organofluoro compounds.
  [FR] La présente invention a trait à un procédé pour la préparation de composés organofluorés contenant du fluor 18 isotope radioactif. Plus particulièrement, la présente invention a trait à un procédé pour la préparation de composé organofluoré par la réaction de sel de fluor contenant du fluor 18 isotope radioactif avec de l'halogénure d'alkyle ou du sulfonate d'alkyle en présence d'alcool de chimie (Fig. 1) sous la forme d'un solvant pour obtenir un rendement élevé de composé organofluoré. La réaction de synthèse selon la présente invention peut être effectuée dans des conditions modérées pour obtenir un rendement élevé de composés organofluorés et le temps de réaction est réduit, et le procédé est donc approprié pour la production de masse de composés organofluorés.