12-(2-fluorophenyl)-9,9-dimethyl-9,10-dihydro-8Hbenzo[a]xanthen-11(12H)-one | 1351996-70-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 新黄酮类化合物
• 英文名称: 12-(2-fluorophenyl)-9,9-dimethyl-9,10-dihydro-8Hbenzo[a]xanthen-11(12H)-one
• 英文别名: 12-(2-fluorophenyl)-9,9-dimethyl-10,12-dihydro-8H-benzo[a]xanthen-11-one
• CAS: 1351996-70-7
• 化学式: C₂₅H₂₁FO₂
• 分子量: 372.439
• InChiKey: AYXZNYMCBJVIPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  28
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5,5-二甲基-1,3-环己二酮 、 2-氟苯甲醛 、 2-萘酚 在 碘 作用下， 以 溶剂黄146 为溶剂， 反应 2.5h， 以76%的产率得到12-(2-fluorophenyl)-9,9-dimethyl-9,10-dihydro-8Hbenzo[a]xanthen-11(12H)-one
  参考文献：
  名称：

  四氢苯并[a]呫吨-11-酮和二氮杂苯并[a]蒽-9,11-二酮衍生物的分子碘催化一锅法合成

  摘要：

  摘要 以分子碘为催化剂，实现了β-萘酚、醛类和环状1,3-二羰基化合物的高效一锅缩合，从而得到多种四氢苯并[a]呫吨-11-酮和二氮杂苯并[a]蒽-9,11-二酮衍生物以良好的产率制备。图形概要

  DOI：

  10.1080/00397911.2010.541966

文献信息

• New nano-Fe₃O₄-supported Lewis acidic ionic liquid as a highly effective and recyclable catalyst for the preparation of benzoxanthenes and pyrroles under solvent-free sonication
  作者：Hai Truong Nguyen、Ngoc-Phuong Thi Le、Duy-Khiem Nguyen Chau、Phuong Hoang Tran

  DOI：10.1039/c8ra04893b

  日期：——

  magnetic nanomaterial-immobilized Lewis acidic ionic liquid was successfully synthesized by the covalent embedding of 3-(3-(trimethoxysilyl)propyl)-1H-imidazol-3-ium chlorozincate (II) ionic liquid to the surface of Fe3O4 nanoparticles. The material was then characterized by FT-IR, SEM, TEM, TGA, ICP-OES, Raman, and EDS. Its performance as a new-generation Lewis acidic catalyst was also examined on the

  将3-(3-(三甲氧基甲硅烷基)丙基)-1 H-咪唑-3-氯锌酸盐( II )离子液体共价嵌入Fe 3 O表面，成功合成了一种新型磁性纳米材料固定化Lewis酸性离子液体4纳米粒子。然后通过 FT-IR、SEM、TEM、TGA、ICP-OES、拉曼和 EDS 对材料进行表征。其作为新一代路易斯酸性催化剂的性能也在超声介导的苯并氧杂蒽和吡咯合成中进行了检验。完成后，通过外部磁铁简单地回收催化剂以进行多次重复使用，而不会显着降低催化性能。
• Molecular iodine-catalyzed one-pot synthesis of tetrahydrobenzo[a]xanthene-11-one and diazabenzo[a]anthracene-9,11-dione derivatives under microwave irradiation
  作者：X. J. Sun、J. F. Zhou、P. S. Zhao

  DOI：10.1002/jhet.742

  日期：2011.11

  An efficient one‐pot condensation of β‐naphthol, aldehydes, and cyclic 1,3‐dicarbonyl compounds has been achieved with molecular iodine as a catalyst under microwave irradiation, thus a variety of tetrahydrobenzo[a]xanthene‐11‐one and diazabenzo[a]anthracene‐9,11‐dione derivatives were prepared in good yields. J. Heterocyclic Chem., (2011).

  在微波辐射下，以分子碘为催化剂，可以实现β-萘酚，醛和环状1,3-二羰基化合物的高效单锅缩合反应，因此可以制得各种四氢苯并[ a ]蒽并十一酮和重氮苯并[以高收率制备了]蒽-9,11-二酮衍生物。J.杂环化​​学。（2011）。
• Preparation of core/shell/shell CoFe ₂ O ₄ /OCMC/Cu (BDC) nanostructure as a magnetically heterogeneous catalyst for the synthesis of substituted xanthenes, quinazolines and acridines under ultrasonic irradiation
  作者：Mohammad Ali Ghasemzadeh、Fatemeh Ghaffarian

  DOI：10.1002/aoc.5580

  日期：2020.5

  Highly efficient synthesized magnetic cobalt ferrite nanoparticles supported on OCMC@Cu (BDC) was utilized in the preparation of biologically active heterocyclic compounds through one‐pot three‐component reactions between of aldehydes, dimedone, aryl amines/2‐naphthol/urea under ultrasonic irradiation. This method has various advantages including excellent yields, little catalyst loading, simple procedure

  在超声波辐射下，通过醛，二甲酮，芳基胺/ 2-萘酚/脲之间的一锅三组分反应，在OCMC @ Cu（BDC）上负载的高效合成磁性钴铁氧体纳米颗粒用于制备生物活性杂环化合物。该方法具有多种优势，包括收率高，催化剂用量少，操作简单，催化剂分离容易，反应时间短，环保方法和纯化简单。通过多种光谱学方法对催化剂进行了表征，例如傅立叶变换红外（FT-IR），能量色散X射线（EDX），扫描电子显微镜（SEM），X射线衍射（XRD）和N 2吸附-解吸等温线（BET）。此外，通过光谱技术表征了杂环化合物。纳米复合材料可通过使用外部磁体简单地分离，并且可以循环使用几次而不会显着降低活性。
• Synthesis and characterization of a novel Brönsted acidic dicationic ionic liquid based on piperazine and its application in the one-pot synthesis of various xanthenes under solvent-free conditions
  作者：Zainab Ehsani-Nasab、Ali Ezabadi

  DOI：10.1007/s11164-022-04666-0

  日期：2022.3

  In this paper, an interesting Brönsted acidic dicationic ionic liquid based on piperazine was prepared via two-step synthesis. The structure of the dicationic ionic liquid (DIL) was confirmed with various techniques including Fourier transform infrared spectroscopy (FT-IR), Proton NMR (1H NMR), Carbon-13 NMR (13C NMR), mass spectroscopy (MS), acid–base titration as well as Hammett acidity function

  在本文中，通过两步合成制备了一种有趣的基于哌嗪的 Brönsted 酸性双阳离子离子液体。双阳离子离子液体 (DIL) 的结构通过多种技术确认，包括傅里叶变换红外光谱 (FT-IR)、质子 NMR ( 1 H NMR)、Carbon-13 NMR ( 13 C NMR)、质谱 (MS)、酸碱滴定和哈米特酸度函数。在呫吨合成中检测了这种新型布朗斯台德酸性 DIL 的催化活性。产品收率高、反应时间短、催化剂易于回收和再利用以及不使用有机溶剂是开发过程的一些优点。
• Synthesis and Characterization of Fe3O4@SiO2 NPs as an Effective Catalyst for the Synthesis of Tetrahydrobenzo[a]xanthen-11-ones
  作者：Mohammad Ali Ghasemzadeh

  DOI：10.17344/acsi.2015.1501

  日期：2015.12.15

  In this research, the significant application of Fe(3)O(4)@SiO(2) core-shell nanoparticles as an efficient, green, robust, cost-effective and recoverable nanocatalyst for multi-component reaction of aldehydes, 2-naphthol and dimedone has been developed in aqueous ethanol media under reflux conditions. This procedure also avoids hazardous reagents/solvents, and thus can be an eco-friendly alternative to the existing methods. Simple procedure, environmentally benign, excellent yields, short reaction times, simple purification and facile catalyst separation are advantages of this protocol. Characterization and structural elucidation of the products have been done on the basis of chemical, analytical and spectral analysis and also the heterogeneous nanoparticles were fully characterized by FT-IR, XRD, EDX, VSM and SEM analysis.