1-Oxo-3,3-dimethyl-7,8-benzo-1,2,3,4-tetrahydro-xanthen | 111273-95-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1-Oxo-3,3-dimethyl-7,8-benzo-1,2,3,4-tetrahydro-xanthen
• 英文别名: 6,6-Dimethyl-1,2-benzo-5,6,7,8-tetrahydro-xanthenon-(8)；9,10-dihydro-9,9-dimethyl-8H-benzo[a]xanthen-11(12H)-one；9,9-dimethyl-8,9,10,12-tetrahydro-11H-benzo[a]xanthen-11-one；9,9-dimethyl-8,9,10,12-tetrahydro-benzo[a]xanthen-11-one；9,9-dimethyl-10,12-dihydro-8H-benzo[a]xanthen-11-one
• CAS: 111273-95-1
• 化学式: C₁₉H₁₈O₂
• 分子量: 278.351
• InChiKey: HZJBBRIGNBBFDZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1-(二甲基胺甲基)萘酚 、 3-(二甲氨基)-5,5-二甲基-2-环己烯-1-酮 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以89%的产率得到1-Oxo-3,3-dimethyl-7,8-benzo-1,2,3,4-tetrahydro-xanthen
  参考文献：
  名称：

  2,3,4,9-Tetrahydro-1H-xanthen-1-ones 和 8,9,10,12-Tetrahydro-11H-benzo[a]xanthen-11-ones 通过捕获 ofo-Quinone 的简便方法方法论

  摘要：

  摘要 2,3,4,9-四氢-1H-xanthene-1-ones 和 8,9,10,12-四氢-11H-benzo[a]xanthene-11-ones 的一种高效、简单的合成方法报道了- 3-二甲氨基-2-环己烯-1-酮与羟基苄醇、苯酚和2-萘酚曼尼希碱或其季铵化衍生物的锅缩合。据信该反应的机理涉及邻醌甲基化物中间体的形成。图形概要

  DOI：

  10.1080/00397911.2010.545164

文献信息

• Solvent-free multicomponent reactions using the novel N-sulfonic acid modified poly(styrene-maleic anhydride) as a solid acid catalyst
  作者：Majid. M. Heravi、Elaheh Hashemi、Yahya Shirazi Beheshtiha、Khadijeh Kamjou、Maryam Toolabi、Nastaran Hosseintash

  DOI：10.1016/j.molcata.2014.04.024

  日期：2014.10
• A multicomponent, solvent-free, one-pot synthesis of benzoxanthenones catalyzed by HY zeolite: their anti-microbial and cell imaging studies
  作者：Velladurai Rama、Kuppusamy Kanagaraj、Kasi Pitchumani

  DOI：10.1016/j.tetlet.2011.10.143

  日期：2012.2

  An atom-economical, multicomponent condensation of naphthols, aldehydes, and cyclic 1,3-dicarbonyl compounds catalyzed by HY zeolites under solvent-free conditions is reported. This ecofriendly protocol offers several advantages such as a green and cost-effective procedure with excellent yield, shorter reaction time, simpler work-up, recovery, and reusability of metal-free solid acid heterogeneous catalyst and tolerance of a wide range of functional groups. The biological studies such as in vitro anti-microbial activities of the prepared new compounds and cell imaging studies on K562 leukemia cell lines by selected benzoxanthenones are evaluated. (C) 2011 Elsevier Ltd. All rights reserved.