N,N-dimethyl-3-oxa-1-pentadecylamine | 51327-68-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-dimethyl-3-oxa-1-pentadecylamine
• 英文别名: (2-dodecyloxy-ethyl)-dimethyl-amine；1-Dimethylamino-2-dodecyloxy-aethan；(2-Dodecyloxy-aethyl)-dimethyl-amin；(2-Dimethylamino-aethyl)-dodecyl-aether；2-(dimethylamino)-ethyl-dodecyl ether；2-(Dodecyloxy)-N,N-dimethylethan-1-amine；2-dodecoxy-N,N-dimethylethanamine
• CAS: 51327-68-5
• 化学式: C₁₆H₃₅NO
• 分子量: 257.46
• InChiKey: DSNJGFLHEVDMHH-UHFFFAOYSA-N

物化性质

• 沸点：
  323.3±15.0 °C(Predicted)
• 密度：
  0.840±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  18
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  氯甲烷 、 N,N-dimethyl-3-oxa-1-pentadecylamine 以 二氯甲烷 为溶剂， 反应 48.0h， 以90%的产率得到N,N,N-trimethyl-3-oxa-1-pentadecylammonium chloride
  参考文献：
  名称：

  Synthesis of Novel Diammonium Gemini Surfactants

  摘要：

  通过在碱性条件下将相应的烷基醇与2-氯-N,N-二甲基乙胺反应，成功实现了线性和双子季铵盐表面活性剂的选择性合成。随后，这些胺类化合物通过甲基氯或甲基碘进行季铵化。

  DOI：

  10.3390/61200979
• 作为产物：
  描述：

  乙二醇单十二烷基醚 在 吡啶 、 氯化亚砜 、 sodium hydroxide 作用下， 以 水 、 甲苯 为溶剂， 反应 18.0h， 生成 N,N-dimethyl-3-oxa-1-pentadecylamine
  参考文献：
  名称：

  一些无环季铵化合物的合成。仲胺和叔胺在两相体系中的烷基化

  摘要：

  通式R1R2R3N+AR4Cl–（R1 = Me, Bu; R2 = n-C12H25, PhCH2, CnH2n+1(OCH2CH2)m, n = 9 and 12, m = 1）的一系列无环对称和不对称季铵氯化物和 2; R3 = n-C12H25, PhCH2, HOCH2CH2,–OOCCH2; R4 = n-C12H25, PhCH2; A = (CH2CH2O)1,2, CH2C(O)O) 是通过叔胺的烷基化合成的相系统含水。一种合成通式 MeNR1R2 的初始对称和不对称叔胺的简便方法（R1 = Me, Bu；R2 = n-C12H25, PhCH2, CnH2n+1(OCH2CH2)m, n = 9 和 12, m = 1 和 2) 在有机相-水相非均相系统中被开发出来，它允许使用碱和胺的水溶液。

  DOI：

  10.1007/s11172-014-0761-x

文献信息

• Hair Growth Regulating Agent
  申请人：Suzuki Yasuto

  公开号：US20110130456A1

  公开（公告）日：2011-06-02

  A hair growth regulating agent containing, as an active ingredient, a compound represented by the following formula (I): [wherein R1 represents a substituted or unsubstituted, linear or branched C2 to C25 alkyl group; a group represented by the following formula (II): (wherein R1′ represents a substituted or unsubstituted, linear or branched C2 to C20 alkylene group, or —(CH2)n-O—(CH2)m}o-O—(CH2)p- in which each of n, m, o, and p is an integer from 1 to 6; X′ represents —CO—NH—, —O—CO—O—, —NH—CO—, —CO—O—, —O—CO—, or —O—; Y′ represents a substituted or unsubstituted C1 to C4 alkylene group; R2′ represents a hydrogen atom or a C1 to C4 alkyl group; R3′ represents a C1 to C4 alkyl group; and when R2′ and R3′ each represent a C1 to C4 alkyl group, the two alkyl groups may be identical to or different from each other); or a group represented by the following formula (III): (wherein R1′, X′, and Y′ have the same meanings as defined above; R4′, R5′, and R6′, which may be identical to or different from one another, each represent a C1 to C4 alkyl group; and A′- represents a counter ion); X represents —CO—NH—, —O—CO—O—, —NH—CO—, —CO—O—, —O—CO—, or —O—; Y represents a substituted or unsubstituted C1 to C4 alkylene group; R2 represents a hydrogen atom or a C1 to C4 alkyl group; R3 represents a C1 to C4 alkyl group; and when R2 and R3 each represent a C1 to C4 alkyl group, the two alkyl groups may be identical to or different from each other] or a salt of the compound; and/or a quaternary ammonium salt represented by the following formula (IV): (wherein R1, X, and Y have the same meanings as defined above; R4, R5, and R6, which may be identical to or different from one another, each represent a C1 to C4 alkyl group; and A- represents a counter ion).

  一种含有以下式（I）所代表的化合物作为活性成分的头发生长调节剂：[其中R1代表取代或未取代的直链或支链C2至C25烷基团；由以下式（II）表示的基团：（其中R1'代表取代或未取代的直链或支链C2至C20烷基烯基团，或者—（CH2）n-O—（CH2）m}o-O—（CH2）p-，其中n，m，o和p中的每个都是1至6的整数；X'代表—CO—NH—，—O—CO—O—，—NH—CO—，—CO—O—，—O—CO—或—O—；Y'代表取代或未取代的C1至C4烷基烯基团；R2'代表氢原子或C1至C4烷基团；R3'代表C1至C4烷基团；当R2'和R3'各自代表C1至C4烷基团时，这两个烷基团可以相同或不同）；或由以下式（III）表示的基团：（其中R1'，X'和Y'的含义与上述定义相同；R4'，R5'和R6'，可以相同也可以不同，各代表C1至C4烷基团；A'-代表一个对离子）；X代表—CO—NH—，—O—CO—O—，—NH—CO—，—CO—O—，—O—CO—或—O—；Y代表取代或未取代的C1至C4烷基烯基团；R2代表氢原子或C1至C4烷基团；R3代表C1至C4烷基团；当R2和R3各自代表C1至C4烷基团时，这两个烷基团可以相同或不同]或该化合物的盐；和/或由以下式（IV）所代表的季铵盐：（其中R1，X和Y的含义与上述定义相同；R4，R5和R6，可以相同也可以不同，各代表C1至C4烷基团；A-代表一个对离子）。
• [EN] USE OF COLIPASE-LIPASE INHIBITORS IN THE PREPARATION OF A PHARMACEUTICAL COMPOSITION IN ORDER TO PREVENT OBESITY<br/>[FR] UTILISATION D'INHIBITEURS DU SYSTEME COLIPASE-LIPASE DANS LA PREPARATION D'UNE COMPOSITION PHARMACEUTIQUE PERMETTANT DE PREVENIR L'OBESITE
  申请人：FORSKARPATENT I SYD AB

  公开号：WO2005018625A1

  公开（公告）日：2005-03-03

  The present invention relates to novel colipase-lipase inhibitors of the general formulae to be used in the treatment or prophylaxis of obesity, as well as pharmaceutical compositions containing the same, and method for treating obesity using said compounds.

  本发明涉及一种新型胰脂酶抑制剂，其通式用于治疗或预防肥胖，以及含有该抑制剂的药物组合物，以及使用这些化合物治疗肥胖的方法。
• Composition for External Application to Skin
  申请人：Suzuki Yasuto

  公开号：US20100273875A1

  公开（公告）日：2010-10-28

  A composition for external application to skin, containing a compound represented by formula (I) or a salt thereof, and/or a quaternary ammonium salt represented by formula (II): wherein R 1 is a substituted or unsubstituted, linear or branched chain alkyl group having 2 to 25 carbon atoms; X is —CO—NH—, —O—CO—O—, —NH—CO—, —CO—O—, —O—CO— or —O—; Y is a substituted or unsubstituted alkylene group having 1 to 4 carbon atoms; R 2 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; R 3 is an alkyl group having 1 to 4 carbon atoms; R 2 and R 3 are the same as or different from each other; R 4 , R 5 and R 6 , which may the same as or different from each other, each are an alkyl group having 1 to 4 carbon atoms; and A − is a counter ion.

  一种用于外用于皮肤的组合物，含有由式（I）或其盐所代表的化合物和/或由式（II）所代表的季铵盐：其中，R1是具有2到25个碳原子的取代或未取代的线性或支链烷基；X是-CO-NH-，-O-CO-O-，-NH-CO-，-CO-O-，-O-CO-或-O-；Y是具有1到4个碳原子的取代或未取代的亚烷基基团；R2是氢原子或具有1到4个碳原子的烷基基团；R3是具有1到4个碳原子的烷基基团；R2和R3相同或不同；R4、R5和R6，它们可以相同也可以不同，每个都是具有1到4个碳原子的烷基基团；A-是一个反离子。
• Physical-chemical and toxicological properties of osmolyte-based cationic surfactants and spontaneously formed low-toxic catanionic vesicles out of them
  作者：Eva Müller、Markus Drechsler、Regina Klein、J. Heilmann、Boris Estrine、Werner Kunz

  DOI：10.1016/j.molliq.2022.119549

  日期：2022.9

  In the context of efficient drug delivery systems, catanionic vesicles offer several advantages, such as spontaneous formation and long-term stability. However, especially the cationic component of such vesicles is often toxic. Thus, the search for less toxic, biocompatible amphiphiles, while maintaining the desirable aggregation properties is crucial. In this work, we present cytotoxicity towards

  在高效药物递送系统的背景下，阳离子囊泡具有多种优势，例如自发形成和长期稳定性。然而，尤其是这种囊泡的阳离子成分通常是有毒的。因此，寻找毒性较小、生物相容的两亲物，同时保持理想的聚集特性是至关重要的。在这项工作中，我们展示了对人类细胞系 Hela 的细胞毒性以及一些基于天然渗透物胆碱和四氢嘧啶的阳离子表面活性剂的生物降解性数据。讨论了这些化合物的合成、聚集和溶解行为以及在水中的稳定性。为了诱导囊泡的自发形成，这些阳离子表面活性剂中的一些与具有不同混合比的不同链长的羧酸胆碱结合，并通过低温透射电镜进行表征。此外，这种新型阳离子化合物的细胞毒性作用被评估为阳离子-阴离子比率的函数，并与十二烷基硫酸钠和十二烷基三甲基溴化铵的经典组合进行比较。
• COMPOSITION FOR EXTERNAL APPLICATION TO SKIN
  申请人：Kao Corporation

  公开号：EP2221040A1

  公开（公告）日：2010-08-25

  A composition for external application to skin, containing a compound represented by formula (I) or a salt thereof, and/or a quaternary ammonium salt represented by formula (II): wherein R1 is a substituted or unsubstituted, linear or branched chain alkyl group having 2 to 25 carbon atoms; X is -CO-NH-, -O-CO-O-, -NH-CO-, - CO-O-, -O-CO- or -O-; Y is a substituted or unsubstituted alkylene group having 1 to 4 carbon atoms; R2 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; R3 is an alkyl group having 1 to 4 carbon atoms; R2 and R3 are the same as or different from each other; R4, R5 and R6, which may the same as or different from each other, each are an alkyl group having 1 to 4 carbon atoms; and A- is a counter ion.

  一种用于皮肤外用的组合物，含有式 (I) 所代表的化合物或其盐，和/或式 (II) 所代表的季铵盐： 其中 R1 是具有 2 至 25 个碳原子的取代或未取代的直链或支链烷基；X 是-CO-NH-、-O-CO-O-、-NH-CO-、-CO-O-、-O-CO-或-O-；Y 是具有 1 至 4 个碳原子的取代或未取代的亚烷基；R2 是氢原子或具有 1 至 4 个碳原子的烷基；R3 是具有 1 至 4 个碳原子的烷基；R2 和 R3 彼此相同或不同；R4、R5 和 R6 可能彼此相同或不同，各自是具有 1 至 4 个碳原子的烷基；以及 A- 是反离子。