N-triacontanoyl-4-hydroxysphinganine | 871541-12-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 鞘脂
• 英文名称: N-triacontanoyl-4-hydroxysphinganine
• 英文别名: N-[(2S,3S,4R)-1,3,4-trihydroxyoctadecan-2-yl]triacontanamide
• CAS: 871541-12-7
• 化学式: C₄₈H₉₇NO₄
• 分子量: 752.302
• InChiKey: HGRBEAWIMWHTJQ-QSYYFJFSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  19.8
• 重原子数：
  53
• 可旋转键数：
  45
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.98
• 拓扑面积：
  89.8
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-triacontanoyl-4-hydroxysphinganine 、 叔丁基二甲硅基三氟甲磺酸酯 在 2,6-二甲基吡啶 作用下， 以 二氯甲烷 为溶剂， 以82%的产率得到
  参考文献：
  名称：

  Novel galactosyl donor with 2-naphthylmethyl (NAP) as the non-participating group at C-2 position: efficient synthesis of α-galactosyl ceramide

  摘要：

  Piedommant alpha-linked products can be generated in glycosylation involving galactosyl trichloroacetimiclate donors with 2-naphthylmethyl (NAP)as the non-participating group at C-2 position The above-mentioned donor was successfully utilized for the synthesis of alpha-galactosyl ceiamide. (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tetlet.2010.06.071
• 作为产物：
  描述：

  糖脂 、 蜡酸 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以92%的产率得到N-triacontanoyl-4-hydroxysphinganine
  参考文献：
  名称：

  Novel galactosyl donor with 2-naphthylmethyl (NAP) as the non-participating group at C-2 position: efficient synthesis of α-galactosyl ceramide

  摘要：

  Piedommant alpha-linked products can be generated in glycosylation involving galactosyl trichloroacetimiclate donors with 2-naphthylmethyl (NAP)as the non-participating group at C-2 position The above-mentioned donor was successfully utilized for the synthesis of alpha-galactosyl ceiamide. (C) 2010 Elsevier Ltd All rights reserved

  DOI：

  10.1016/j.tetlet.2010.06.071

文献信息

• Novel galactosyl donor with 2-naphthylmethyl (NAP) as the non-participating group at C-2 position: efficient synthesis of α-galactosyl ceramide
  作者：Sirajud D. Khaja、Vipin Kumar、Misbah Ahmad、Jun Xue、Khushi L. Matta

  DOI：10.1016/j.tetlet.2010.06.071

  日期：2010.8

  Piedommant alpha-linked products can be generated in glycosylation involving galactosyl trichloroacetimiclate donors with 2-naphthylmethyl (NAP)as the non-participating group at C-2 position The above-mentioned donor was successfully utilized for the synthesis of alpha-galactosyl ceiamide. (C) 2010 Elsevier Ltd All rights reserved