(E)-1,3-bis(allyloxy)-5-(4-(allyloxy)styryl)benzene | 1284251-10-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E)-1,3-bis(allyloxy)-5-(4-(allyloxy)styryl)benzene
• 英文别名: 1,3-bis(prop-2-enoxy)-5-[(E)-2-(4-prop-2-enoxyphenyl)ethenyl]benzene
• CAS: 1284251-10-0
• 化学式: C₂₃H₂₄O₃
• 分子量: 348.442
• InChiKey: AYMAJUGVHSTHRM-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  26
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  白藜芦醇 、 3-溴丙烯 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 6.0h， 生成 (E)-1,3-bis(allyloxy)-5-(4-(allyloxy)styryl)benzene 、 (E)-3-(allyloxy)-5-(4-(allyloxy) styryl) phenolbenzene
  参考文献：
  名称：

  Synthesis and evaluation of resveratrol derivatives as new chemical entities for cancer

  摘要：

  Resveratrol has been shown to be active in inhibiting multistage carcinogenesis. The potential use of resveratrol in cancer chemoprevention or chemotherapy settings has been hindered by its short half-life and low bioavailability. Considering the above remarks, using resveratrol as a prototype, we have synthesized two derivatives of resveratrol. Their activity was evaluated using in vitro and in silica analysis. Biological evaluation of resveratrol analogues on U937 cells had shown that two synthesized analogues of resveratrol had higher rates of inhibition than the parental molecule at 10 mu M concentration. EMSA conducted for NF-kB revealed that these molecules significantly interfered in the DNA binding ability of NF-kB. It was found that these molecules suppressed the expression of TNF alpha, TNFR, IL-8, actin and activated the expression of FasL, FasR genes. To understand possible molecular mechanism of the action we performed docking and dynamic studies, using NF-kB as a receptor. Results showed that resveratrol, RA1 and RA2 interacted with the residues involved in DNA binding. Resveratrol analogues by interacting NF-kB might have prevented its translocation and also by interacting with the residues involved in DNA binding might have prevented the binding of NP-kB to DNA. This may be the reason for suppression of NF-kB binding to DNA. (C) 2013 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.jmgm.2013.01.005

文献信息

• Crosslinkers from biorenewable resveratrol
  申请人：International Business Machines Corporation

  公开号：US10233289B2

  公开（公告）日：2019-03-19

  A process includes utilizing biorenewable resveratrol or a resveratrol-derived material as a bio-derived crosslinker to form a crosslinked polymeric material.

  一种工艺包括利用可生物再生的白藜芦醇或白藜芦醇衍生材料作为生物衍生交联剂，形成交联聚合物材料。
• CROSSLINKERS FROM BIORENEWABLE RESVERATROL
  申请人：International Business Machines Corporation

  公开号：US20180215875A1

  公开（公告）日：2018-08-02

  A process includes utilizing biorenewable resveratrol or a resveratrol-derived material as a bio-derived crosslinker to form a crosslinked polymeric material.
• LIGHT-TRIGGERED SUSTAINED RELEASE OF PESTICIDES
  申请人：International Business Machines Corporation

  公开号：US20190350194A1

  公开（公告）日：2019-11-21

  A process of forming a sustained-release pesticide coating, a process of forming a sustained-release pesticide capsule, and a sustained-release pesticide coating are disclosed. The process of forming the sustained-release pesticide coating includes depositing a first layer that includes a first pesticide onto a surface, and depositing a second layer that includes a photodegradable material onto the first layer. The process of forming the sustained-release pesticide coating also includes depositing a third layer that includes a second pesticide onto the second layer. The process of forming the sustained release pesticide capsule includes selecting a pesticide, selecting a photosensitive compound, and encapsulating the pesticide in a photosensitive capsule that includes a polymer formed from the photosensitive compound. The sustained-release pesticide coating includes a pesticide and a material having a photosensitive component. The material is in contact with the pesticide, and temporarily prevents the pesticide from contacting a surface.
• US9920171B1
  申请人：——

  公开号：US9920171B1

  公开（公告）日：2018-03-20
• Synthesis and evaluation of resveratrol derivatives as new chemical entities for cancer
  作者：Chaitanya Mulakayala、B. Babajan、P. Madhusudana、C.M. Anuradha、Raja Mohan Rao、Ravi Prakash Nune、Sunil Kumar Manna、Naveen Mulakayala、Chitta Suresh Kumar

  DOI：10.1016/j.jmgm.2013.01.005

  日期：2013.4

  Resveratrol has been shown to be active in inhibiting multistage carcinogenesis. The potential use of resveratrol in cancer chemoprevention or chemotherapy settings has been hindered by its short half-life and low bioavailability. Considering the above remarks, using resveratrol as a prototype, we have synthesized two derivatives of resveratrol. Their activity was evaluated using in vitro and in silica analysis. Biological evaluation of resveratrol analogues on U937 cells had shown that two synthesized analogues of resveratrol had higher rates of inhibition than the parental molecule at 10 mu M concentration. EMSA conducted for NF-kB revealed that these molecules significantly interfered in the DNA binding ability of NF-kB. It was found that these molecules suppressed the expression of TNF alpha, TNFR, IL-8, actin and activated the expression of FasL, FasR genes. To understand possible molecular mechanism of the action we performed docking and dynamic studies, using NF-kB as a receptor. Results showed that resveratrol, RA1 and RA2 interacted with the residues involved in DNA binding. Resveratrol analogues by interacting NF-kB might have prevented its translocation and also by interacting with the residues involved in DNA binding might have prevented the binding of NP-kB to DNA. This may be the reason for suppression of NF-kB binding to DNA. (C) 2013 Elsevier Inc. All rights reserved.