N-<<4-(Dimethylamino)phenyl>methylene>-2-methyl-2-propanamine N-oxide | 98236-04-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-<<4-(Dimethylamino)phenyl>methylene>-2-methyl-2-propanamine N-oxide
• 英文别名: N-tert-butyl α-(4-dimethylaminophenyl) nitrone；N-tert-butyl-1-[4-(dimethylamino)phenyl]methanimine oxide
• CAS: 98236-04-5；127896-01-9
• 化学式: C₁₃H₂₀N₂O
• 分子量: 220.315
• InChiKey: FRAVSLIDIFEIAM-GDNBJRDFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  32
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-[(E)-(tert-butylimino)methyl]-N,N-dimethylaniline 在 间氯过氧苯甲酸 作用下， 以 氘代氯仿 为溶剂， 生成 N-<<4-(Dimethylamino)phenyl>methylene>-2-methyl-2-propanamine N-oxide
  参考文献：
  名称：

  Boyd, Derek R.; Coulter, Peter B.; McGuckin, M. Rosaleen, Journal of the Chemical Society. Perkin transactions I, 1990, # 2, p. 301 - 306

  摘要：

  DOI：

文献信息

• 1H and13C NMR Spectra of (Z)-C-arylN-tert-butyl nitrones
  作者：Robert W. Murray、Megh Singh

  DOI：10.1002/mrc.1260290917

  日期：1991.9

  The 1H and 13C NMR spectra of 12 (Z)‐C‐aryl N‐tert‐butyl nitrones were measured and proton and carbon assignments made. The nitrones were synthesized by the dimethyldioxirane method.

  测量了 12 (Z)-C-芳基 N-叔丁基硝酮的 1H 和 13C NMR 谱，并进行了质子和碳分配。硝酮通过二甲基二环氧乙烷法合成。
• Chromium and Tungsten Pentacarbonyl Groups as Reactivity and Selectivity Auxiliaries in [3 + 2] Cycloaddition of Alkynyl Fischer Carbene Complexes with N-Alkyl Nitrones
  作者：Kin Shing Chan、Ming Lok Yeung、Wai-kin Chan、Ru-Ji Wang、Thomas C. W. Mak

  DOI：10.1021/jo00111a036

  日期：1995.3

  Alkynyl Fischer carbene complexes were found to undergo chemoselective, regioselective, and rate-enhanced 1,3-dipolar cycloaddition with nitrones to give 2,3-dihydroisoxazole carbene complexes in excellent yields. These alkynyl complexes can serve as synthons for substituted propiolate esters since the metal pentacarbonyl group of the cycloadducts can be easily oxidatively removed with DMSO. The tungsten carbene complex 4b reacted with 3 different series of N-alkyl nitrones: N-tert-butyl 2a-f, N-methyl 1a-h and N-benzyl 3 to give cycloadducts 6a-f, 7a-h, and 8-9, respectively, while the chromium carbene complex 4a reacted only with N-tert-butyl nitrones 2a-g to give isolable cycloadducts 5a-g. The structure of N-methyl cycloadduct 7d has been established by a single-crystal X-ray analysis. The reactivity of N-alkyl nitrones toward carbene complexes was in the order: N-Me > N-Bn > N-(t)Bu. In addition, our results showed that the rate of cycloaddition reaction increased as the electron donating ability of para-substituent in N-tert-butyl nitrone 2a-f increased.
• Normal, abnormal and pseudo-abnormal reaction pathways for the imine-peroxyacid reaction
  作者：Derek R. Boyd、Peter B. Coulter、Narain D. Sharma、W.Brian Jennings、Valerie E. Wilson

  DOI：10.1016/s0040-4039(00)98582-4

  日期：1985.1
• α-Phenyl-N-tert-butyl nitrone (PBN) derivatives: Synthesis and protective action against microvascular damages induced by ischemia/reperfusion
  作者：Sothea Kim、Guilherme V.M. de A. Vilela、Jalloul Bouajila、Ayres G. Dias、Fatima Z.G.A. Cyrino、Eliete Bouskela、Paulo R.R. Costa、Françoise Nepveu

  DOI：10.1016/j.bmc.2007.02.033

  日期：2007.5

  Nitrones 4-7, structurally related to PBN (1), were prepared by reaction of the corresponding aromatic aldehydes with N-tert-butyl hydroxylamine. The protective effects of these nitrones against microvascular damages in ischemia/reperfusion in the 'hamster cheek pouch' assay were studied and 1, as well as 4a, 4b, and 7 (derived from piperonal, O-benzyl vanillin, and furfural, respectively), showed to be more active than shark cartilage or a-tocopherol. No correlation was found between the protective effect of these nitrones and their log P (partition coefficient) or their capacity to trap OH and CH3 radicals. (c) 2007 Elsevier Ltd. All rights reserved.