5,6-diacetoxy-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene | 856209-25-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 5,6-diacetoxy-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene
• 英文别名: 5,6-Diacetoxy-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromen；5,6-diacetoxy-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene；(6-acetyloxy-2,2-dimethyl-3,4-dihydrobenzo[h]chromen-5-yl) acetate
• CAS: 856209-25-1
• 化学式: C₁₉H₂₀O₅
• 分子量: 328.365
• InChiKey: GNYVKJSLJFDQFJ-UHFFFAOYSA-N

物化性质

• 沸点：
  481.3±45.0 °C(Predicted)
• 密度：
  1.193±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5,6-diacetoxy-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene 在 air 、 硫酸 、 溶剂黄146 作用下， 生成 3,4-二氢-2,2-二甲基-2H-萘并[1,2-B]吡喃-5,6-二酮
  参考文献：
  名称：

  The Constitution of Lapachol and its Derivatives. Part V. The Structure of Paternò's “Isolapachone”^1,2

  摘要：

  DOI：

  10.1021/ja01298a033
• 作为产物：
  描述：

  3,4-二氢-2,2-二甲基-2H-萘并[1,2-B]吡喃-5,6-二酮 在 乙醇 、 sodium 作用下， 生成 5,6-diacetoxy-2,2-dimethyl-3,4-dihydro-2H-benzo[h]chromene
  参考文献：
  名称：

  Paterno; Minunni, Gazzetta Chimica Italiana, 1889, vol. 19, p. 611

  摘要：

  DOI：

文献信息

• USE OF PRODRUG COMPOSITION CONTAINING NAPHTHOQUINONE-BASED COMPOUND FOR MANUFACTURE OF MEDICAMENT FOR TREATMENT OR PREVENTION OF DISEASES INVOLVING METABOLIC SYNDROME
  申请人：YOO Sang-Ku

  公开号：US20090124680A1

  公开（公告）日：2009-05-14

  Provided is a use of a prodrug composition containing a naphthoquinone-based compound of Formula 1 for the manufacture of a medicament for treatment or prevention of metabolic syndrome diseases. wherein R 1 to R 10 , X, m and n are as defined in the specification.

  提供一种使用基于萘醌化合物1式的前药组合物的方法，用于制造治疗或预防代谢综合征疾病的药物。其中R1到R10，X，m和n的定义见规范。
• Monti, Gazzetta Chimica Italiana, 1915, vol. 45 II, p. 56
  作者：Monti

  DOI：——

  日期：——
• ALBUMIN NANOPARTICLES, THE MAKING METHOD, AND USES THEREOF
  申请人：NOVAGENESIS THERAPEUTIX (HK) LIMITED

  公开号：US20220118057A1

  公开（公告）日：2022-04-21

  The present disclosure provides an albumin nanoparticle comprising a core consisting of at least one diester derivative of β-lapachone and a shell consisting of at least one albumin. Further, herein provided are a preparation method and use thereof. The albumin nanoparticle has a significantly longer in vivo half-life, markedly reduced toxicity and side effects, and an observably widened therapeutic window, and thus can treat cancer associated with KRAS mutations.
• [EN] QUINONE PROTECTED FORMS AND CONJUGATES<br/>[FR] FORMES PROTÉGÉES DE QUINONE ET CONJUGUÉS
  申请人：[en]CAMBRIDGE ENTERPRISE LIMITED

  公开号：WO2023227757A1

  公开（公告）日：2023-11-30

  The invention provides protected ortho-quinone compounds comprising a group represented by: Formula (I) where -Ar- is optionally substituted phenylene, -X is selected from -NH2, -OH and -SH, and the protected forms of each, -W- is optionally substituted methylene, such as methylene, and d is a double or single bond, and the salts and solvates thereof
• The Constitution of Lapachol and its Derivatives. Part V. The Structure of Paternò's “Isolapachone”^1,2
  作者：Samuel C. Hooker

  DOI：10.1021/ja01298a033

  日期：1936.7