1,2-(ethylene)bis{[(adamant-1-yl)methyl]urea} | 1607795-30-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机碳酸及其衍生物
• 英文名称: 1,2-(ethylene)bis{[(adamant-1-yl)methyl]urea}
• 英文别名: 1,1'-(ethane-1,2-diyl)bis[3-(adamantan-1-ylmethyl)urea]；1-(1-Adamantylmethyl)-3-[2-(1-adamantylmethylcarbamoylamino)ethyl]urea；1-(1-adamantylmethyl)-3-[2-(1-adamantylmethylcarbamoylamino)ethyl]urea
• CAS: 1607795-30-1
• 化学式: C₂₆H₄₂N₄O₂
• 分子量: 442.645
• InChiKey: HXECQCIECLBWLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  32
• 可旋转键数：
  7
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  82.3
• 氢给体数：
  4
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  乙二胺 、 1-(isocyanatomethyl)adamantane 以 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以99%的产率得到1,2-(ethylene)bis{[(adamant-1-yl)methyl]urea}
  参考文献：
  名称：

  Synthesis of adamantyl-containing 1,3-disubstituted diureas and thioureas, efficient targeted inhibitors of human soluble epoxide hydrolase

  摘要：

  合成了一系列含有刚性烷基的1,3-二取代二脲和硫脲，这些化合物在脲基团与刚性烷基取代基之间具有不同的间隔，且已研究其对哺乳动物和人类可溶性环氧化酶水解酶（sEH，E.C. 3.3.2.10）的抑制活性。合成的化合物在0.4–2.8 nmol L−1的浓度范围内表现出高抑制活性。抑制剂结构与其活性之间的关系已经确定。

  DOI：

  10.1007/s11172-015-1043-y

文献信息

• Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors
  作者：Vladimir Burmistrov、Christophe Morisseau、Kin Sing Stephen Lee、Diyala S. Shihadih、Todd R. Harris、Gennady M. Butov、Bruce D. Hammock

  DOI：10.1016/j.bmcl.2014.03.016

  日期：2014.5

  A series of inhibitors of the soluble epoxide hydrolase (sEH) containing two urea groups has been developed. Inhibition potency of the described compounds ranges from 2.0 mu M to 0.4 nM. 1,6-(Hexamethylene)bis[(adamant-1-yl) urea] (3b) was found to be a potent slow tight binding inhibitor (IC50 = 0.5 nM) with a strong binding to sEH (K-i = 3.1 nM) and a moderately long residence time on the enzyme (k(off) = 1.05 x 10(-3) s(-1); t(1/2) = 11 min). (C) 2014 Elsevier Ltd. All rights reserved.
• Synthesis of adamantyl-containing 1,3-disubstituted diureas and thioureas, efficient targeted inhibitors of human soluble epoxide hydrolase
  作者：G. M. Butov、V. V. Burmistrov、D. V. Danilov、D. A. Pitushkin、C. Morisseau、B. D. Hammock

  DOI：10.1007/s11172-015-1043-y

  日期：2015.7

  A series of adamantyl-containing 1,3-disubstituted diureas and thioureas containing different spacers between the ureylene group and the adamantyl substituent has been synthesized, their inhibitory activity against mammalian and human soluble epoxide hydrolase (sEH, E.C. 3.3.2.10) has been examined. The compounds synthesized were found to exhibit high inhibitory activity on the 0.4–2.8 nmol L−1 level. The dependence between the inhibitor structure and its activity was established

  合成了一系列含有刚性烷基的1,3-二取代二脲和硫脲，这些化合物在脲基团与刚性烷基取代基之间具有不同的间隔，且已研究其对哺乳动物和人类可溶性环氧化酶水解酶（sEH，E.C. 3.3.2.10）的抑制活性。合成的化合物在0.4–2.8 nmol L−1的浓度范围内表现出高抑制活性。抑制剂结构与其活性之间的关系已经确定。