1-ethyl-3-(2-hydroxyethyl)-2-<3-(1,3-dihydro-1,3,3-trimethyl-2H-indol-2-ylidene)-1-propenyl>-1H-naphth<2,3-d>imidazolium chloride | 139167-50-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-ethyl-3-(2-hydroxyethyl)-2-<3-(1,3-dihydro-1,3,3-trimethyl-2H-indol-2-ylidene)-1-propenyl>-1H-naphth<2,3-d>imidazolium chloride
• 英文别名: 2-[1-ethyl-2-[3-(1,3,3-trimethylindol-2-ylidene)prop-1-enyl]benzo[f]benzimidazol-3-ium-3-yl]ethanol;chloride
• CAS: 139167-50-3
• 化学式: C₂₉H₃₂N₃O*Cl
• 分子量: 474.046
• InChiKey: QUJVBTDPUDQNST-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  2.42
• 重原子数：
  34
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1H-2-methylnaphtho[2,3-d]imidazole 在 氢氧化钾 、 amberlite IRA-400 chloride ion-exchange resin 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 丙酮 为溶剂， 反应 10.5h， 生成 1-ethyl-3-(2-hydroxyethyl)-2-<3-(1,3-dihydro-1,3,3-trimethyl-2H-indol-2-ylidene)-1-propenyl>-1H-naphth<2,3-d>imidazolium chloride
  参考文献：
  名称：

  Synthesis and substance P antagonist activity of naphthimidazolium derivatives

  摘要：

  The synthesis of unsymmetrical naphth[2,3-d]imidazolium and bridged naphth[2,3-d]imidazolium derivatives and their substance P (SP) antagonist activity are described. All compounds were evaluated for their ability to displace SP from neurokinin-1 (NK-1) receptor sites using standard receptor binding methodology (rat forebrain membrane). 1,3-Diethyl-2-[3-(1,3-dihydro-1,3,3-trimethyl-2H-indol-2-ylidene)-1-propenyl]-1H-naphth[2,3-d]imidazolium chloride (7a), a representative compound in this series, was further evaluated for SP antagonist activity in a guinea pig ileum contractility assay. In vivo SP antagonist activity of 7a was demonstrated using SP-induced salivation and paw edema models performed in rats.

  DOI：

  10.1021/jm00085a015

文献信息

• Synthesis and substance P antagonist activity of naphthimidazolium derivatives
  作者：Kristine B. Lawrence、Bhaskar R. Venepalli、Kenneth C. Appell、Ramanuj Goswami、Margaret E. Logan、Bruce E. Tomczuk、John M. Yanni

  DOI：10.1021/jm00085a015

  日期：1992.4

  The synthesis of unsymmetrical naphth[2,3-d]imidazolium and bridged naphth[2,3-d]imidazolium derivatives and their substance P (SP) antagonist activity are described. All compounds were evaluated for their ability to displace SP from neurokinin-1 (NK-1) receptor sites using standard receptor binding methodology (rat forebrain membrane). 1,3-Diethyl-2-[3-(1,3-dihydro-1,3,3-trimethyl-2H-indol-2-ylidene)-1-propenyl]-1H-naphth[2,3-d]imidazolium chloride (7a), a representative compound in this series, was further evaluated for SP antagonist activity in a guinea pig ileum contractility assay. In vivo SP antagonist activity of 7a was demonstrated using SP-induced salivation and paw edema models performed in rats.