N-(3-dimethylamino-propyl)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-imine | 47201-20-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 二苯并环庚烯
• 英文名称: N-(3-dimethylamino-propyl)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-imine
• 英文别名: N,N-dimethyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylideneamino)propan-1-amine
• CAS: 47201-20-7
• 化学式: C₂₀H₂₄N₂
• 分子量: 292.424
• InChiKey: NBOTVTKJRBAJLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  15.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  10,11-二氢二苯并[a,b]环庚烯-5-酮 在 四氯化钛 、 对甲苯磺酸 作用下， 以 苯 为溶剂， 反应 352.0h， 生成 N-(3-dimethylamino-propyl)-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-imine
  参考文献：
  名称：

  Imine analogs of tricyclic antidepressants

  摘要：

  Analogues of tricyclic antidepressants were synthesized in which the alpha-carbon of the side chain was replaced by nitrogen. The antidepressant activity of these imines, as measured by the reversal of the effects of tetrabenazine in mice, showed a structure-activity relationship similar to that of the carbon analogues. The most active imine (19) was six times as potent as amitriptyline. Some of the compounds differed from amitriptyline in that they produced stimulation in mice.

  DOI：

  10.1021/jm00135a018

文献信息

• Tricyclic imines
  申请人：Hoffmann-La Roche Inc.

  公开号：US04003915A1

  公开（公告）日：1977-01-18

  Tricyclic imines of the formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, X, m and n are as hereinafter described, prepared from the corresponding ketones of the formula ##STR2## wherein R.sup.1, X and m are as hereinafter described, are disclosed. The compounds of formula I are useful as antidepressants, as well as anticonvulsants and agents for the treatment of Parkinsonism.

  公开了公式##STR1##中R.sup.1、R.sup.2、R.sup.3、R.sup.4、X、m和n如下所述的三环亚胺，其由公式##STR2##中R.sup.1、X和m如下所述的相应酮制备而成。公式I的化合物可用作抗抑郁药、抗癫痫药以及帕金森病治疗药物。
• CH541545
  申请人：——

  公开号：——

  公开（公告）日：——
• US4003915A
  申请人：——

  公开号：US4003915A

  公开（公告）日：1977-01-18
• Imine analogs of tricyclic antidepressants
  作者：Engelbert Ciganek、Roy T. Uyeda、Marvin Cohen、Dewey H. Smith

  DOI：10.1021/jm00135a018

  日期：1981.3

  Analogues of tricyclic antidepressants were synthesized in which the alpha-carbon of the side chain was replaced by nitrogen. The antidepressant activity of these imines, as measured by the reversal of the effects of tetrabenazine in mice, showed a structure-activity relationship similar to that of the carbon analogues. The most active imine (19) was six times as potent as amitriptyline. Some of the compounds differed from amitriptyline in that they produced stimulation in mice.