fluorescein-O,O-bis-methylstyrene | 1372709-31-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: fluorescein-O,O-bis-methylstyrene
• 英文别名: (4-Ethenylphenyl)methyl 2-[3-[(4-ethenylphenyl)methoxy]-6-oxoxanthen-9-yl]benzoate；(4-ethenylphenyl)methyl 2-[3-[(4-ethenylphenyl)methoxy]-6-oxoxanthen-9-yl]benzoate
• CAS: 1372709-31-3
• 化学式: C₃₈H₂₈O₅
• 分子量: 564.637
• InChiKey: DCIJVKSKQCMDFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  43
• 可旋转键数：
  10
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  61.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  4-氯甲基苯乙烯 、 荧光素 在 四丁基氢氧化铵 作用下， 以 四氢呋喃 、 水 、 氯仿 为溶剂， 反应 21.0h， 以89%的产率得到fluorescein-O,O-bis-methylstyrene
  参考文献：
  名称：

  Functionalised, photostable, fluorescent polystyrene nanoparticles of narrow size-distribution

  摘要：

  Fluorescent nanoparticles continue to be of wide interest, as they have many advantages over single fluorescent molecules for biological imaging and sensing applications, such as increased fluorescence intensity and reduced photobleaching. In the following work, styrene was copolymerised with a newly synthesised, fluorescein-based, vinylic crosslinking monomer, by emulsion polymerisation, to create a series of different sized fluorescent nanoparticles (35-100 nm), each of narrow size-distribution. The particles were found to be highly fluorescent and with lower photobleaching compared to fluorescein isothiocyanate (FITC), offering an attractive alternative. The fluorescence excitation and emission spectra were recorded, being similar to fluorescein, but with interesting variation in the excitation spectra. The particles also have a wide range of potential uses, such as examining particle uptake activity of a macrophage cell line, also demonstrated. The nanoparticles were coated with albumin to provide functionality for potential conjugation to biological targeting agents. (C) 2011 published by Elsevier B.V.

  DOI：

  10.1016/j.jphotochem.2011.11.012

文献信息

• Functionalised, photostable, fluorescent polystyrene nanoparticles of narrow size-distribution
  作者：Michal Pellach、Jenny Goldshtein、Ofra Ziv-Polat、Shlomo Margel

  DOI：10.1016/j.jphotochem.2011.11.012

  日期：2012.1

  Fluorescent nanoparticles continue to be of wide interest, as they have many advantages over single fluorescent molecules for biological imaging and sensing applications, such as increased fluorescence intensity and reduced photobleaching. In the following work, styrene was copolymerised with a newly synthesised, fluorescein-based, vinylic crosslinking monomer, by emulsion polymerisation, to create a series of different sized fluorescent nanoparticles (35-100 nm), each of narrow size-distribution. The particles were found to be highly fluorescent and with lower photobleaching compared to fluorescein isothiocyanate (FITC), offering an attractive alternative. The fluorescence excitation and emission spectra were recorded, being similar to fluorescein, but with interesting variation in the excitation spectra. The particles also have a wide range of potential uses, such as examining particle uptake activity of a macrophage cell line, also demonstrated. The nanoparticles were coated with albumin to provide functionality for potential conjugation to biological targeting agents. (C) 2011 published by Elsevier B.V.