dichloro-cis-1,2-cyclohexanediamine platinum | 61848-70-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: dichloro-cis-1,2-cyclohexanediamine platinum
• 英文别名: 1,2-diaminocyclohexaneplatinum(II) chloride；(cis-cyclohexane-1,2-diamine)dichloroplatinum(II)；cis-diaminocyclohexane-platinum(II) chloride；cis-dichloro(cis-1,2-diaminocyclohexane)platinum(II)；dichloro(cis-1,2-diaminocyclohexane)platinum(II)；cis-PtCl2[(1R,2R)-1,2-diaminocyclohexane]；[Pt(meso-1,2-diaminocyclohexane)Cl2]；cis-Dichloro(meso-1,2-diaminocyclohexane)platinum；(1R,2S)-cyclohexane-1,2-diamine;platinum(2+);dichloride
• CAS: 61848-70-2
• 化学式: C₆H₁₄Cl₂N₂Pt
• 分子量: 380.177
• InChiKey: PNNCIXRVXCLADM-UOXVPMNTSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  1.59
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  dichloro-cis-1,2-cyclohexanediamine platinum 在 吡啶 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以52.8%的产率得到
  参考文献：
  名称：

  Kinetics of the reaction of dichloro-trans-rac- and -cis-meso-1,2-diaminocyclohexaneplatinum(II) with pyridine

  摘要：

  The kinetics of the reaction [Pt(dach)Cl2] + py- [Pt(dach)(py)CI]Cl (dach = either trans-rac- or cis-meso-1,2-diaminocyclohexane, py = pyridine) has been studied in dimethylformamide (dmf) solution, under pseudo-first-order conditions (excess of pyridine), in the range 50-80-degrees-C, by measuring the increase in conductance of the solution. In dmf the products behave like weak electrolytes, with dissociation constants of about 1.4 x 10(-3) mol dm-3 . The reactions were found to be reversible under the experimental conditions. Owing to the uncertainty in evaluating the equilibrium concentrations, the kinetic constants k(obs) have been calculated from the initial slopes (up to 1 5% conversion) of first-order plots. Their values obey the equation k(obs) = k1 + k2[py], k1 being about two orders of magnitude lower than k2. The values of k(obs) for the cis derivative are always slightly but significantly higher than those of the trans. The activation parameters have been evaluated only for k2, since the k1 values are affected by too high uncertainties: DELTAH(double dagger) trans 76(1), cis 79(1) kJ mol-1; DELTAS(double dagger) trans -101(3), cis -92(3) J K-1 mol-1. The higher rate for the cis isomer is interpreted in terms of higher flexibility of the diamine chelate ring.

  DOI：

  10.1039/dt9930001231
• 作为产物：
  描述：

  (R,S)-1,2-diaminocyclohexane chloro dimethylsulfoxide platinum(II)chloride 在 lithium chloride 作用下， 以 水 为溶剂， 以67%的产率得到dichloro-cis-1,2-cyclohexanediamine platinum
  参考文献：
  名称：

  Biological activity of platinum complexes containing chiral centers on the nitrogen or carbon atoms of a chelate diamine ring

  摘要：

  DOI：

  10.1016/s0020-1693(00)87114-5

文献信息

• FLUORESCENT ANTICANCER PLATINUM DRUGS
  申请人：INVICTUS ONCOLOGY PVT. LTD.

  公开号：US20180312534A1

  公开（公告）日：2018-11-01

  The present disclosure is in relation to the field of nanotechnology and cancer therapeutics. In particular, the present disclosure relates to fluorescent platinum based compounds. The disclosure further relates to synthesis of said fluorescent platinum based compounds, nanoparticles and compositions comprising said fluorescent platinum based compounds/nanoparticles. The disclosure also relates to methods of managing cancer by the fluorescence changes between aforesaid platinum based compounds and corresponding free ligands, nanoparticles and compositions.

  本公开涉及纳米技术和癌症治疗领域。具体而言，本公开涉及荧光铂基化合物。该公开进一步涉及合成所述荧光铂基化合物、纳米颗粒和包含所述荧光铂基化合物/纳米颗粒的组合物。该公开还涉及通过上述铂基化合物与相应的游离配体、纳米颗粒和组合物之间的荧光变化来管理癌症的方法。
• CATALYST FOR SYNTHESIZING METHANOL OR ITS PRECURSOR, METHOD FOR PREPARING THE CATALYST AND METHOD FOR PRODUCING METHANOL OR ITS PRECURSOR USING THE CATALYST
  申请人：KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

  公开号：US20180118772A1

  公开（公告）日：2018-05-03

  Disclosed is a novel catalyst having amine ligands for synthesizing methanol or its precursor. When the catalyst is allowed to react with an alkane in the presence of an acid, at least one C—H bond of the alkane is catalytically oxidized. Therefore, the catalyst is suitable for use in forming an alkyl ester from an alkane.

  公开了一种具有胺配体的新型催化剂，用于合成甲醇或其前体。当催化剂在酸的存在下与烷烃反应时，至少有一个烷烃的C—H键被催化氧化。因此，该催化剂适用于从烷烃中形成烷基酯。
• Thermal decomposition of a generation 4.5 PAMAM dendrimer platinum drug conjugate
  作者：B. A. Howell、D. Fan、Leela Rakesh

  DOI：10.1007/s10973-005-7333-0

  日期：2006.7

  A nanoscale multivalent platinum drug based on a poly(amidoamine) [PAMAM] dendrimer (generation 4.5, carboxylate surface) has been synthesized and fully characterized using a variety of spectroscopic, chromatographic and thermal methods. Treatment of the dendrimer with an aqueous solution containing an excess diaquo( cis -1,2-diaminocyclohexane)platinum(II) produces a conjugate containing approximately

  已经合成了一种基于聚（酰胺基胺）[PAMAM]树状大分子（4.5代，羧酸酯表面）的纳米级多价铂药物，并使用多种光谱，色谱和热方法对其进行了全面表征。用含有过量的二氢（ 顺式 -1,2，-二氨基环己烷）铂（II）的水溶液处理树枝状聚合物，在树枝状聚合物 的表面上产生含有约四十个（二氨基环己烷）铂（II）部分的缀合物。该材料经历平稳的两阶段热分解，以提供残留的氧化铂，反映出药物中的铂含量。
• Aspects of the stereochemistry of bis-guanosine-5′-monophosphate diamine platinum complexes
  作者：Alessandro Pasini、Laura De Giacomo

  DOI：10.1016/0020-1693(96)05006-2

  日期：1996.7

  of some [PtA2(GMP)2]2− complexes (A = NH3, or A2 - ethylenediamine, 1,3-propylenediamine R,R-, S,S- and meso-1,2-diaminocyclohexane and R,R-, S,S- and meso-2,3-diaminobutane; GMP = N(7)-coordinated guanosine-5′-monophosphate) have been investigated by means of circular dichroism (CD) spectroscopy. There is only one 1H NMR detectable isomer for the majority of the complexes, whose CD spectra suggest

  某些[PtA2（GMP）2] 2-配合物在水溶液中的构象（A = NH3或A2-乙二胺，1,3-丙二胺R，R-，S，S-和内消旋1,2-已通过圆二色性（CD）光谱研究了二氨基环己烷和R，R-，S，S-和内消旋2,3-二氨基丁烷; GMP = N（7）配位的鸟苷5'-单磷酸酯）。大多数配合物只有一个1H NMR可检测到的异构体，其CD光谱显示⋀HT构象，并在Pt-N（7）键周围逆时针倾斜，产生右旋，螺旋桨状，鸟嘌呤平面​​的空间排列。S，S-二胺的衍生物，显示两个NMR可观察到的异构体，显示相反符号的CD光谱，大概是由在更丰富的构象异构体中围绕Pt-N（7）的顺时针倾斜产生的。将尿素添加到后面这些化合物的溶液中，仅产生一个构象异构体（NMR证据），R，R-二胺衍生物的CD光谱相同，而NMR和CD光谱不受尿素的影响。结论是，各种[PtA2（GMP）2] 2-的构象取决于胺-嘌呤氢键与嘌呤-嘌呤相互作用之间的竞争。
• Cationic diamineplatinum (II) complexes of nalidixic acid
  作者：Sung Sil Lee、Ok-Sang Jung、Chong Ock Lee、Sang Un Choi、Moo-Jin Jun、Youn Soo Sohn

  DOI：10.1016/0020-1693(95)04734-4

  日期：1995.11

  cationic platinum complexes cis-[A2Pt(nal)]+X− (1, A2 = ethylenediamine (en), X = Cl; 2, A2 = (1R,2R)-diaminocyclohexane (dach), X = Cl; 3, A2 = 1,1-bis(aminomethyl) cyclohexane (bamch), X = Cl; 4, A = cyclopropylamine (cpa), X = Cl; 5, A = ammonia, X = nal). The complexes have been characterized by elemental analysis, conductivity, spectroscopic methods and X-ray analysis. The crystal structure of 5·5H2O

  的反应顺式-A 2氯铂酸2与nalidixate钠（NAL）通向阳离子铂络合物的顺- [A 2的Pt（NAL）] + X - （1，A 2 =乙二胺（EN），X =氯; 2，A 2＝（1 R，2 R）-二氨基环己烷（dach），X ＝ Cl；3，A 2＝ 1，1-双（氨基甲基）环己烷（bamch），X ＝ Cl；4，A ＝环丙胺（cpa ），X = Cl; 5，A =氨，X =最终）。通过元素分析，电导率，光谱法和X射线分析对复合物进行了表征。5 ·5H 2 O（空间基团；a = 10.558（3））的晶体结构表明，一个萘啶酸根离子通过其羧酸根和环羰基与铂原子螯合，而另一种萘啶酸根离子是抗衡阴离子。在水中稳定，但在二甲亚砜溶液中转变为Me 2 SO加合物，其中标题化合物2和5显示出良好的抗肿瘤活性，有待进一步研究。