3-(Azetidin-3-yl)propanenitrile | 1205749-29-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环丁烷
• 英文名称: 3-(Azetidin-3-yl)propanenitrile
• 英文别名: 3-(azetidin-3-yl)propanenitrile
• CAS: 1205749-29-6
• 化学式: C₆H₁₀N₂
• 分子量: 110.16
• InChiKey: WLWYNSFXYYVMPO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  35.8
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with cyclic amino group
  申请人：TAISHO PHARMACEUTICAL CO., LTD

  公开号：EP1787992A1

  公开（公告）日：2007-05-23

  An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastric diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, etc. [SOLUTION] A pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic amino group represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.

  本发明的目的是提供一种针对 CRF 受体的拮抗剂，该拮抗剂可有效治疗或预防被认为与 CRF 有关的疾病，如抑郁症、焦虑症、阿尔茨海默病、帕金森病、亨廷顿舞蹈症、饮食失调、高血压、胃病、药物依赖、癫痫、脑梗塞、脑缺血、脑水肿、头外伤、炎症、免疫相关疾病、脱发、肠易激综合征、睡眠障碍、癫痫、皮肤病、精神分裂症等。 [解决方案］ 由下式[I]代表的环状氨基取代的吡咯并嘧啶或吡咯并嘧啶衍生物： 对 CRF 受体具有高亲和力，对 CRF 被认为参与的疾病有效。