3-methoxy-16,17-seco-estra-1,3,5(10)-trien-17-al | 39780-07-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3-methoxy-16,17-seco-estra-1,3,5(10)-trien-17-al
• 英文别名: 3-Methoxy-16,17-seco-oestra-1,3,5(10)-trien-17-al；3-methoxy-16,17-secoestra-1,3,5(10)-trien-17-al；(1S,2S,4aS,10aR)-1-ethyl-7-methoxy-2-methyl-3,4,4a,9,10,10a-hexahydro-1H-phenanthrene-2-carbaldehyde
• CAS: 39780-07-9
• 化学式: C₁₉H₂₆O₂
• 分子量: 286.414
• InChiKey: SZLCBVCHFRHCSR-AKHDSKFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (4aS)-7-methoxy-2t-methyl-2c-hydroxymethyl-1t-ethyl-(4arH.10atH)-1,2,3,4,4a,9,10,10a-octahydro-phenanthrene 在 potassium permanganate 、 硫酸 、 铬酸 作用下， 以 丙酮 为溶剂， 生成 3-methoxy-16,17-seco-estra-1,3,5(10)-trien-17-al
  参考文献：
  名称：

  16,17-Seco-delta 4,9(10) and -delta 4,9(10),11 steroids

  摘要：

  这些化合物及其14.beta.-异构体可用作抗雄激素药物，并提供了它们的制备方法。

  公开号：

  US03969412A1

文献信息

• Can the human intervertebral disc be compared to a diarthrodial joint?
  作者：B. Grignon、J. Roland

  DOI：10.1007/s00276-000-0101-8

  日期：2000.8

  The joint between human vertebral bodies is traditionally classified as a symphysis, a major cartilaginous synarthrosis. However, it has been suggested by some authors to compare the intervertebral disc (IVD) to a diarthrodial joint. The bases of this comparison are reviewed and discussed. In his description of 1895, Luschka saw the IVD as a diarthrodial joint containing articular cartilages and synovium in the annulus fibrosus. Subsequently, histologic and ultrastructural investigations into the cells and extracellular matrix of the nucleus pulposus (NP) supported the same hypothesis. More recently, the appearances of the IVD in magnetic resonance imaging (MRI) and discography, as well as clinical considerations were interpreted in the same way to simplify understanding of IVD pathology. However, a number of objections involving general, morphological, embryological, biochemical, histologic, radiological and clinical considerations demonstrate the limitations of this hypothesis. The general structural and mechanical principles of joint classification are mentioned to highlight the basic differences between the IVD and a synovial joint. An overview of the development of these joints, and a review of the literature dealing with ultrastructural aspects of the NP, with histopathological studies of the IVD, and with the normal appearance of the IVD on MRI and its age-related changes has led us to refute the hypothesis of this analogy. The IVD cannot be compared to a synovial joint, explaining why most of its pathologic features are quite different from those of a joint of the appendicular skeleton.
• US3969412A
  申请人：——

  公开号：US3969412A

  公开（公告）日：1976-07-13
• 16,17-Seco-delta 4,9(10) and -delta 4,9(10),11 steroids
  申请人：Syntex (U.S.A.) Inc.

  公开号：US03969412A1

  公开（公告）日：1976-07-13

  The novel 16,17-secoestra-4,9(10)-diene, 16,17-secoestra-4,9(10),11-triene, 16,17-secogona-4,9(10)-diene and 16,17-secogona-4,9(10)-triene compounds and the 14.beta.-isomers thereof useful as antiandrogenic agents, and methods for their preparation.

  这些化合物及其14.beta.-异构体可用作抗雄激素药物，并提供了它们的制备方法。