1-butylphenothiazine | 97679-30-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 1-butylphenothiazine
• 英文别名: 1-n-butyl-10H-phenothiazine；Butylphenothiazine；1-butyl-10H-phenothiazine
• CAS: 97679-30-6
• 化学式: C₁₆H₁₇NS
• 分子量: 255.384
• InChiKey: RBZIZRCOJINOMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-butylphenothiazine 在 碘 作用下， 以 氯仿 、 乙腈 为溶剂， 反应 7.0h， 生成 3,7-Dimorpholino-1-n-butylphenothiazin-5-ium iodide
  参考文献：
  名称：

  Antiviral Compounds

  摘要：

  提供了预防和治疗病毒感染的化合物和方法。在某些实施例中，提供了新型化合物广谱抗病毒活性。在更具体的实施例中，这些化合物和方法对委内瑞拉马蹄热病毒、西尼罗河病毒和丙型肝炎等病毒具有有效性。

  公开号：

  US20120270854A1
• 作为产物：
  描述：

  正丁基锂 、 2-氯吩噻嗪 在 水 作用下， 以 乙醚 、 正己烷 为溶剂， 反应 7.0h， 以71%的产率得到1-butylphenothiazine
  参考文献：
  名称：

  Antiviral Compounds

  摘要：

  提供了预防和治疗病毒感染的化合物和方法。在某些实施例中，提供了新型化合物广谱抗病毒活性。在更具体的实施例中，这些化合物和方法对委内瑞拉马蹄热病毒、西尼罗河病毒和丙型肝炎等病毒具有有效性。

  公开号：

  US20120270854A1

文献信息

• MULTIFUNCTIONAL LUBRICATING OIL BASE STOCKS AND PROCESSES FOR PREPARING SAME
  申请人：ExxonMobil Research and Engineering Company

  公开号：US20190169519A1

  公开（公告）日：2019-06-06

  A composition that includes one or more compounds represented by the formula wherein R1 and R2 are same or different and are the residue of an alkyl group having more than 10 carbon atoms wherein the composition has a viscosity (Kv 100 ) from 2 to 300 at 100° C. as determined by ASTM D-445, and a viscosity index (VI) from −100 to 300 as determined by ASTM D-2270. The disclosure also relates to a process for producing the composition, a lubricating oil base stock and lubricating oil containing the composition, and a method for improving oxidative stability of a lubricating oil by using as the lubricating oil a formulated oil containing the composition.

  一个包括一个或多个化合物的组成，其化学式为其中R1和R2相同或不同，是具有超过10个碳原子的烷基基团的残基，该组成物在100° C下由ASTM D-445确定的粘度（Kv100）为2至300，由ASTM D-2270确定的粘度指数（VI）为-100至300。该公开还涉及生产该组成物的方法，润滑油基础油和含有该组成物的润滑油，以及通过使用含有该组成物的配方油作为润滑油来提高润滑油的氧化稳定性的方法。
• Additives and lubricant formulations for improved antioxidant properties
  申请人：Esche K. Carl

  公开号：US20060205615A1

  公开（公告）日：2006-09-14

  A method and compositions for lubricating surfaces with lubricating oils exhibiting increased antioxidant properties. The lubricated surface includes a lubricant composition containing a base oil of lubricating viscosity and an amount of at least one hydrocarbon soluble metal compound effective to provide a reduction in oxidation of the lubricant composition greater than a reduction in oxidation of the lubricant composition devoid of the hydrocarbon soluble metal compound. The metal of the metal compound is selected from the group consisting of titanium, zirconium, and manganese.

  一种润滑表面的方法和组合物，使用具有增强抗氧化性质的润滑油润滑。润滑表面包括一种润滑剂组合物，其中包含具有润滑粘度的基础油和至少一种亲水烃溶性金属化合物，其有效提供的润滑剂组合物的氧化还原反应的抑制程度大于不含亲水烃溶性金属化合物的润滑剂组合物的氧化还原反应的抑制程度。金属化合物的金属选自钛、锆和锰组成的组。
• BIOLOGICALLY ACTIVE METHYLENE BLUE DERIVATIVES
  申请人：Brown Stanley Beames

  公开号：US20080275033A1

  公开（公告）日：2008-11-06

  A phenothiazinium compound of Formula (I) wherein: A and B each independently is in which R′ and R″ each independently is a linear, branched or cyclic hydrocarbon group, or R′ and R″ together with the N atom to which they are attached form an optionally substituted 5-, 6- or 7-membered ring; and where X P− is a counteranion and P is 1, 2 or 3; except for the compounds in which A and B are both either —N(CH 3 ) 2 or —N(CH 2 CH 3 ) 2 for use in a treatment that requires removal, deactivation or killing of unwanted tissues or cells.

  公式（I）中的苯并噻唑化合物，其中：A和B各自独立地为以下结构： 其中，R'和R''各自独立地为线性、支链或环烃基，或者R'和R''与它们所连接的N原子形成一个可选的取代的5、6或7元环； 并且，XP-是一个反离子，P为1、2或3；但是当A和B均为—N(CH3)2或—N(CH2CH3)2时，不适用于需要去除、失活或杀死不需要的组织或细胞的治疗。
• Biologically active methylene blue derivatives
  申请人：Brown Stanley Beames

  公开号：US20080261960A1

  公开（公告）日：2008-10-23

  The present invention relates to a phenothiazinium compound of Formula (I): wherein: A and B each independently is in which R′ and R″ each independently is a linear, branched or cyclic hydrocarbon group, or R′ and R″ together with the N atom to which they are attached form an optionally substituted 5-, 6- or 7-membered ring; and where X P− is a counteranion and P is 1, 2 or 3; except for the compounds in which A and B are both either —N(CH 3 ) 2 or —N(CH 2 CH 3 ) 2 for use in a treatment that requires removal, deactivation or killing of unwanted tissues or cells. The invention also relates to compositions comprising the compounds of Formula I, to selected compounds of Formula I, use of the compounds of Formula I as medicaments and as a PDT agent or a photodiagnostic agent, a conjugate or composite formed between a compound of Formula I and a polymer; and to a method for sterilising fluids in which the fluid is passed over the conjugate or composite whilst it is illuminated. The compounds are biologically active photosensitisers which are strongly photocytotoxic and have application in the areas of photodynamic therapy (PDT), as well as for the diagnosis and detection of medical conditions and related uses in photochemical internalisation, in the production of cancer vaccines, in the treatment and prevention of microbial infections and in photodisinfection or photosterilisation.

  本发明涉及式(I)的苯并噻吩化合物：其中：A和B各自独立地为-CH2-或-NR'-，其中R'和R''各自独立地为线性、支链或环烃基，或R'和R''与它们所连接的N原子一起形成一个可选的取代的5、6或7元环；XP-为一种计数阴离子，P为1、2或3；除了A和B都是-N(CH3)2或-N(CH2CH3)2的化合物用于需要去除、失活或杀死不需要的组织或细胞的治疗。本发明还涉及包含式(I)化合物的组合物，选择的式(I)化合物，使用式(I)化合物作为药物和作为光动力治疗剂或光诊断剂，以及在化合物(I)和聚合物之间形成的共轭物或复合物；以及在照明时将流体通过共轭物或复合物以灭菌的方法。这些化合物是具有生物活性的光敏剂，具有强烈的光细胞毒性，在光动力疗法（PDT）领域以及用于医学状况的诊断和检测以及与内部光化学作用有关的用途中，如癌症疫苗的生产、微生物感染的治疗和预防以及光消毒或光灭菌等方面有应用。
• Additives comprising a hydrocarbon soluble titanium compound and lubricant formulations for providing friction modification
  申请人：Afton Chemical Corporation

  公开号：EP1788067A1

  公开（公告）日：2007-05-23

  Lubricated surfaces, lubricant compositions for lubricating a surface, and methods for reducing friction coefficients in lubricants. The lubricated surface is provided by a lubricant composition containing a base oil of lubricating viscosity and an amount of at least one hydrocarbon soluble titanium compound effective to provide a reduction in the coefficient of friction of the lubricant composition greater than a reduction in the coefficient of friction of the lubricant composition devoid of the hydrocarbon soluble titanium compound.

  润滑表面、用于润滑表面的润滑剂组合物以及降低润滑剂摩擦系数的方法。润滑表面由一种润滑剂组合物提供，该组合物含有具有润滑粘度的基础油和一定量的至少一种烃溶性钛化合物，其有效降低润滑剂组合物摩擦系数的程度大于降低不含烃溶性钛化合物的润滑剂组合物摩擦系数的程度。