β-chloro-isobutylamine | 30533-56-3

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氯化物
• 英文名称: β-chloro-isobutylamine
• 英文别名: 2-chloro-2-methylpropylamine；1-Amino-2-chlor-2-methyl-propan；β-Chlor-isobutylamin；1-Amino-2-chlor-2-methylpropan；2-Chlor-2-methyl-1-propylamin；2-Chlorisobutylamin；2-Chloro-2-methylpropan-1-amine
• CAS: 30533-56-3
• 化学式: C₄H₁₀ClN
• mdl: MFCD19203418
• 分子量: 107.583
• InChiKey: LOUHLMICRIPPTD-UHFFFAOYSA-N

物化性质

• 沸点：
  126.2±23.0 °C(Predicted)
• 密度：
  0.980±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  6
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  β-chloro-isobutylamine 、 姜黄素 在 三乙胺 、 三氯氧磷 作用下， 以 二氯甲烷 为溶剂， 反应 28.0h， 以54.3%的产率得到bis{4-[(1E,6E)-7-(4-hydroxy-3-methoxyphenyl)-3,5-dioxohepta-1,6-diene-1-yl]-2-methoxyphenyl}-N-(2-chloro-2-methylpropyl)aminophosphonate
  参考文献：
  名称：

  一种胺基磷酸双姜黄素酯类化合物、制备方法 及用途

  摘要：

  本发明公开了一种胺基磷酸双姜黄素酯类化合物、制备方法及用途，属于药物化学领域。所述化合物其结构式如下：式(I)中R1和R2可环合形成饱和含氮杂环结构，即如下结构：所述化合物的制备方法为，先制备出胺基磷酰氯或硫代胺基磷酰氯，再与姜黄素反应即可得到本发明所述的化合物。所述的胺基磷酸双姜黄素酯类化合物具有较好的抗肿瘤活性，且化合物毒性比顺铂小，可用于制备抗肺癌、胃癌、白血病、乳腺癌及抗炎药物中。

  公开号：

  CN105294756B
• 作为产物：
  描述：

  1-氨基-2-甲基-2-丙醇 在 盐酸 、 水 作用下， 生成 β-chloro-isobutylamine
  参考文献：
  名称：

  Reactions of Ethylenimines. V. Hydrolysis¹

  摘要：

  DOI：

  10.1021/ja01624a048

文献信息

• Benzazepine derivatives
  申请人：E. R. Squibb & Sons, Inc.

  公开号：US04748239A1

  公开（公告）日：1988-05-31

  Vasodilating activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof.

  扩血管活性由具有以下结构式的化合物和其药用可接受的盐所表现。
• Heterocyclic compounds
  申请人：——

  公开号：US20020198237A1

  公开（公告）日：2002-12-26

  Pharmaceutically useful heterocyclic compounds, compositions containing them, and methods of using them, for example, as histamine H 3 receptor mediators.

  药用的杂环化合物，含有它们的组合物以及使用它们的方法，例如，作为组胺H3受体介导剂。
• Therapeutic agent for osteoporosis and diazepine compound
  申请人：Yoshitomi Pharmaceutical Industries, Ltd.

  公开号：US05593988A1

  公开（公告）日：1997-01-14

  A therapeutic agent for osteoporosis, comprising an azepine compound of the formula ##STR1## wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof as an active ingredient, a method for treating osteoporosis comprising administering said compound and a use of said compound for the production of a therapeutic agent for osteoporosis. The compounds of the formula (I) have superior bone resorption-inhibitory activity and act to reduce the increased amount of calcium in blood serum, which is caused by bone resorption. Accordingly, these compounds are usable as pharmaceutical agents to effectively inhibit bone resorption, to prevent decrease of bone mass and to prevent or suppress the increase of calcium amount in blood serum which is caused by the progress of bone resorption, with regard to Paget's disease, hypercalcemia, osteoporosis and so on in which the progress of bone resorption is considered to be deeply associated with the symptom, and to the symptoms of progressing bone resorption (development into osteoporosis) along with inflammatory joint diseases such as rheumatoid arthritis.

  一种治疗骨质疏松症的药物，包含式##STR1##所示的氮杂环庚烷化合物，其中每个符号的定义如说明书中所述，或其药学上可接受的盐作为活性成分，治疗骨质疏松症的方法包括给予所述化合物，以及所述化合物用于制备治疗骨质疏松症药物的用途。式(I)的化合物具有优异的骨吸收抑制活性，并能减少由骨吸收引起的血清钙增加量。因此，这些化合物可用作药物，有效抑制骨吸收，预防骨量减少，并预防或抑制由骨吸收进展引起的血清钙含量增加，涉及佩吉特病、高钙血症、骨质疏松症等，其中骨吸收的进展被认为与症状密切相关，以及随着炎症性关节疾病如类风湿性关节炎进展，骨吸收进展（发展为骨质疏松症）的症状。
• Pyridylalkyl esters of 2-(p-isobutylphenyl)acetic acid and propionic
  申请人：Hisamitsu Pharmaceutical Co. Inc.

  公开号：US04150137A1

  公开（公告）日：1979-04-17

  The present invention relates to phenylacetic acid ester derivatives of the following general formula: ##STR1## wherein, R is selected from the group consisting of lower alkyl (other than ethyl) and substituted lower alkyl, and R' may be a hydrogen or methyl. The compounds obtained by the present invention possess a high degree of analgetic ,antipyretic and anti-inflammatory activites and cause little side effects on the gastro-intestinal tracts, when administered orally and topically, and they may be useful as oral and topical analgetics, antipyretics and antiinflammatory agents.

  本发明涉及以下一般公式的苯乙酸酯衍生物：##STR1##其中，R从由较低的烷基（不包括乙基）和取代的较低烷基组成的群体中选择，R'可以是氢或甲基。本发明得到的化合物具有较高的镇痛、退热和抗炎活性，在口服和局部给药时对胃肠道的副作用很小，它们可能作为口服和局部的镇痛剂、退热剂和抗炎剂有用。
• Pyranoindole derivatives as antiulcer agents
  申请人：Ayerst McKenna and Harrison Ltd.

  公开号：US04066780A1

  公开（公告）日：1978-01-03

  Pyranoindole and thiopyranoindole derivatives characterized by having an amino(lower)alkyl radical attached to either or both the 1 and 9 position of a pyrano[3,4-b]indole or thiopyrano[3,4-b]indole nucleus or having said radical attached to the 1 position of a pyrano[4,3-b]indole or thiopyrano[4,3-b]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated into a heterocyclic amine radical. The derivatives having the amino(lower)alkyl radical only at position 1 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7,8, and 9. The pyrano[3,4-b]indole or thiopyrano[3,4-b]indole derivatives having the amino(lower)alkyl radical only at position 9 possess two substitutents at position 1 and may be optionally substituted at position 3,4,5,6,7, and 8; the derivatives having an amino(lower)alkyl radical at both positions 1 and 9 are further substituted at position 1 and may be optionally substituted at positions 3,4,5,6,7 and 8. The pyrano-and thiopyranoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the preparation and use of these derivatives are also disclosed.

  Pyranoindole和thiopyranoindole衍生物的特征在于在pyrano[3,4-b]indole或thiopyrano[3,4-b]indole核的1和9位置之一或两者上附加有氨基(较低)烷基基团，或者在pyrano[4,3-b]indole或thiopyrano[4,3-b]indole核的1位置上附加有该基团。氨基(较低)烷基基团的氨基部分可能进一步被一个或两个较低烷基基团取代，或者被并入一个杂环胺基团。只在位置1具有氨基(较低)烷基基团的衍生物在位置1进一步被取代，并且可以选择在位置3,4,5,6,7,8和9处被取代。只在位置9具有氨基(较低)烷基基团的pyrano[3,4-b]indole或thiopyrano[3,4-b]indole衍生物在位置1处具有两个取代基，并且可以选择在位置3,4,5,6,7和8处被取代；在位置1和9处都具有氨基(较低)烷基基团的衍生物在位置1处进一步被取代，并且可以选择在位置3,4,5,6,7和8处被取代。本发明的pyrano和thiopyranoindole衍生物可用作抗抑郁和抗溃疡剂。还公开了这些衍生物的制备和使用方法。