dimer of 2,6-dimethyl-3,5-di(carbomethoxy)-4-(2'-nitrosophenyl)pyridine | 142271-31-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: dimer of 2,6-dimethyl-3,5-di(carbomethoxy)-4-(2'-nitrosophenyl)pyridine
• CAS: 142271-31-6
• 化学式: C₃₄H₃₂N₄O₁₀
• 分子量: 656.649
• InChiKey: GPWCRBXLUPAXNX-UHFFFAOYSA-N

物化性质

• 沸点：
  752.5±70.0 °C(Predicted)
• 密度：
  1.295±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.63
• 重原子数：
  48.0
• 可旋转键数：
  8.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  183.12
• 氢给体数：
  0.0
• 氢受体数：
  12.0

反应信息

• 作为产物：
  描述：

  硝苯地平 以 甲醇 为溶剂， 反应 0.75h， 以4%的产率得到dimer of 2,6-dimethyl-3,5-di(carbomethoxy)-4-(2'-nitrosophenyl)pyridine
  参考文献：
  名称：

  Effect of nifedipine on alkaloid accumulation in Catharanthus roseus cell cultures

  摘要：

  The effect of nifedipine on both alkaloid accumulation and calcium uptake in Catharanthus roseus cell cultures was investigated. It was shown that nifedipine inhibited ajmalicine accumulation through a mechanism other than blocking of the calcium channel uptake. Moreover, nifedipine was biotransformed into its 4-(2'-aminophenyl)-pyridine derivative.

  DOI：

  10.1016/0031-9422(92)83115-f

文献信息

• Effect of nifedipine on alkaloid accumulation in Catharanthus roseus cell cultures
  作者：J.M. Mérillon、D. Liu、Y. Laurent、M. Rideau、C. Viel

  DOI：10.1016/0031-9422(92)83115-f

  日期：1992.5

  The effect of nifedipine on both alkaloid accumulation and calcium uptake in Catharanthus roseus cell cultures was investigated. It was shown that nifedipine inhibited ajmalicine accumulation through a mechanism other than blocking of the calcium channel uptake. Moreover, nifedipine was biotransformed into its 4-(2'-aminophenyl)-pyridine derivative.