(R,R)-3,5-bis-{4-[2,2'-dihydroxy-1,1'-binaphthalen-6-yl]-butoxy}-benzyl acrylate | 581799-94-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (R,R)-3,5-bis-{4-[2,2'-dihydroxy-1,1'-binaphthalen-6-yl]-butoxy}-benzyl acrylate
• 英文别名: [3,5-Bis[4-[6-hydroxy-5-(2-hydroxynaphthalen-1-yl)naphthalen-2-yl]butoxy]phenyl]methyl prop-2-enoate；[3,5-bis[4-[6-hydroxy-5-(2-hydroxynaphthalen-1-yl)naphthalen-2-yl]butoxy]phenyl]methyl prop-2-enoate
• CAS: 581799-94-2
• 化学式: C₅₈H₅₀O₈
• 分子量: 875.03
• InChiKey: SFQJECPWMSKXRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.3
• 重原子数：
  66
• 可旋转键数：
  18
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  126
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以1.15 g的产率得到(R,R)-3,5-bis-{4-[2,2'-dihydroxy-1,1'-binaphthalen-6-yl]-butoxy}-benzyl acrylate
  参考文献：
  名称：

  Polymer-Supported BisBINOL Ligands for the Immobilization of Multicomponent Asymmetric Catalysts

  摘要：

  [GRAPHICS]Polymer-supported bisBINOL ligands were successfully utilized for the immobilization of multicomponent asymmetric catalysts. The polymer-supported Al-Li-bis(binaphthoxide) (ALB) catalyst was more effective than the dendrimer-supported ALB in the Michael reaction of 2-cyclohexen-1-one with dibenzyl malonate affording the adduct in 91% yield with 96% ee. The polymer was also effective for the immobilization of a mu-oxodititanium complex that promoted carbonyl-ene reaction of ethyl glyoxalate with alpha-methyl styrene to provide the adduct with up to 98% ee.

  DOI：

  10.1021/ol034797l

文献信息

• Polymer-Supported BisBINOL Ligands for the Immobilization of Multicomponent Asymmetric Catalysts
  作者：Tetuya Sekiguti、Yoshimasa Iizuka、Shinobu Takizawa、Doss Jayaprakash、Takayoshi Arai、Hiroaki Sasai

  DOI：10.1021/ol034797l

  日期：2003.7.1

  [GRAPHICS]Polymer-supported bisBINOL ligands were successfully utilized for the immobilization of multicomponent asymmetric catalysts. The polymer-supported Al-Li-bis(binaphthoxide) (ALB) catalyst was more effective than the dendrimer-supported ALB in the Michael reaction of 2-cyclohexen-1-one with dibenzyl malonate affording the adduct in 91% yield with 96% ee. The polymer was also effective for the immobilization of a mu-oxodititanium complex that promoted carbonyl-ene reaction of ethyl glyoxalate with alpha-methyl styrene to provide the adduct with up to 98% ee.