2-(cyclohexylamino)phenol | 87271-55-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(cyclohexylamino)phenol
• 英文别名: cyclohexylaminophenol；N-cyclohexyl aminophenol
• CAS: 87271-55-4
• 化学式: C₁₂H₁₇NO
• 分子量: 191.273
• InChiKey: NQTSBOHCYASAMX-UHFFFAOYSA-N

物化性质

• 熔点：
  83-84 °C(Solv: hexane (110-54-3))
• 沸点：
  329.0±25.0 °C(Predicted)
• 密度：
  1.126±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  O-phenylhydroxylamine 在 氢氧化钾 、 三氟乙酸 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 8.0h， 生成 2-(cyclohexylamino)phenol
  参考文献：
  名称：

  An Acid-Catalyzed Rearrangement ofN-Alkyl-N′-phenoxyureas; Synthesis of 2-Alkylaminophenols from Phenols

  摘要：

  DOI：

  10.1055/s-1983-30386

文献信息

• Efficient Biocatalytic Reductive Aminations by Extending the Imine Reductase Toolbox
  作者：Gheorghe-Doru Roiban、Marcelo Kern、Zhi Liu、Julia Hyslop、Pei Lyn Tey、Matthew S. Levine、Lydia S. Jordan、Kristin K. Brown、Timin Hadi、Leigh Anne F. Ihnken、Murray J. B. Brown

  DOI：10.1002/cctc.201701379

  日期：2017.12.20

  significant sustainability and selectivity challenges. Biocatalytic alternatives, such as enzyme‐catalyzed reductive amination, offer several advantages over traditional chemistry, but industrial applicability has not yet been demonstrated. Herein, we report the use of cell lysates expressing imine reductases operating at 1:1 stoichiometry for a variety of amines and carbonyls. A collection of biocatalysts

  手性仲胺和叔胺在制药，精细和特种化学品中无处不在，但它们的合成通常面临重大的可持续性和选择性挑战。生物催化替代品，例如酶催化的还原胺化，相对于传统化学方法具有许多优势，但尚未证明其工业适用性。在本文中，我们报道了表达亚胺还原酶的细胞裂解物对多种胺和羰基化合物的化学计量比为1：1的操作。介绍了具有小分子覆盖范围和直接工业适用性的生物催化剂的集合。
• A Pd-catalyzed cascade reaction of N–H insertion and oxidative dehydrogenative aromatization: a new entry to 2-amino-phenols
  作者：Dong Ding、Xiaobing Lv、Jian Li、Lin Qiu、Guangyang Xu、Jiangtao Sun

  DOI：10.1039/c4ob00652f

  日期：——

  A palladium-catalyzed cascade reaction of N–H insertion (NHI) and oxidative dehydrogenative aromatization (ODA) has been developed, which affords a straightforward and efficient way to access the carbazole precursors (2-arylamino-phenols) as well as to prepare 2-alkylamino-phenols from non-aromatic substrates.

  已经开发了钯催化的NH插入（NHI）和氧化脱氢芳构化（ODA）的级联反应，这为获得咔唑前体（2-芳基氨基酚）提供了一种简单有效的方法，并制备了2来自非芳族底物的-烷基氨基酚。
• [EN] SULFONATED PHENOLS WITH NITROPHENOLS AS POLYMERIZATION INHIBITORS<br/>[FR] PHENOLS SULFONES AVEC NITROPHENOLS COMME INHIBITEURS DE POLYMERISATION
  申请人：CHEMTURA CORP

  公开号：WO2006036274A1

  公开（公告）日：2006-04-06

  Disclosed herein is a method for inhibiting the premature polymerization and the polymer growth of ethylenically unsaturated monomers comprising adding to said monomers an effective amount of a combination of (A) at least one inhibitor that is a sulfonated phenol of the formula (I): wherein (1) R2 is selected from the group consisting of hydrogen and hydrocarbyl; and (2) R1 and R3 are independently selected from the group consisting of hydrogen and SO3H, provided that at least one of R1 and R3 is SO3H; (B) at least one inhibitor that is a nitrophenol; and, optionally, (C) an inhibitor selected from the group consisting of nitroxyl compounds and nitrosoanilines; and (D) an amine.

  本文公开了一种抑制乙烯基不饱和单体的过早聚合和聚合生长的方法，包括向该单体中添加以下组合物的有效量：（A）至少一种为公式（I）的磺化酚抑制剂，其中（1）R2选自氢和烃基组成的群体；（2）R1和R3独立地选自氢和SO3H组成的群体，但其中至少一个为SO3H；（B）至少一种为硝基酚的抑制剂；以及可选地，（C）从硝基氧化物化合物和硝基苯胺组成的群体中选择的抑制剂；和（D）胺。
• INDOLE AND BENZOXAZINE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
  申请人：Cid-Nunez Jose Maria

  公开号：US20120035167A1

  公开（公告）日：2012-02-09

  The present invention relates to novel indole and benzoxazine derivatives which are positive allosteric modulators of the metabotropic glutamate receptor subtype 2 (“mGluR2”) and which are useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which the mGluR2 subtype of metabotropic receptors is involved. The invention is also directed to pharmaceutical compositions comprising such compounds, to processes to prepare such compounds and compositions, and to the use of such compounds for the prevention or treatment of neurological and psychiatric disorders and diseases in which mGluR2 is involved.

  本发明涉及新型吲哚和苯并噁嗪衍生物，其为代谢型谷氨酸受体亚型2（“mGluR2”）的正向变构调节剂，并且对于治疗或预防与谷氨酸功能障碍相关的神经和精神障碍以及涉及代谢型受体亚型mGluR2的疾病具有用途。本发明还涉及包含这些化合物的制药组合物，制备这些化合物和组合物的过程以及使用这些化合物预防或治疗涉及mGluR2的神经和精神障碍和疾病。
• Improved method for producing cycloalkyl aminophenol derivatives
  申请人：KANZAKI PAPER MANUFACTURING COMPANY LIMITED

  公开号：EP0181505A1

  公开（公告）日：1986-05-21

  Cycloalkyl aminophenol derivatives are produced by reacting o-, m- or p-aminophenol with a cycloalkanone having 5 to 12 carbon atoms in the presence of a reducing agent and preferably with the addition of an acid.

  环烷基氨基苯酚衍生物是由邻氨基苯酚、间氨基苯酚或对氨基苯酚与具有 5 至 12 个碳原子的环烷基酮在还原剂的存在下，最好是在加入酸的情况下反应生成的。