(20S)-5-cyano-3,3-(ethylenedioxy)-20-(p-toluenesulfonyloxymethyl)-5β-pregn-8-ene | 356063-36-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (20S)-5-cyano-3,3-(ethylenedioxy)-20-(p-toluenesulfonyloxymethyl)-5β-pregn-8-ene
• 英文别名: [(2S)-2-[(5'S,10'R,13'R,14'R,17'R)-5'-cyano-10',13'-dimethylspiro[1,3-dioxolane-2,3'-2,4,6,7,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene]-17'-yl]propyl] 4-methylbenzenesulfonate
• CAS: 356063-36-0
• 化学式: C₃₂H₄₃NO₅S
• 分子量: 553.763
• InChiKey: QSLLFUWHKKZDTC-IZGVYPQTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  39
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  94
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (20S)-5-cyano-3,3-(ethylenedioxy)-20-(p-toluenesulfonyloxymethyl)-5β-pregn-8-ene 、 环己基溴化镁 生成 (20R)-21-cyclohexyl-5-cyano-3,3-(ethylenedioxy)-20-methyl-5β-pregn-8-ene
  参考文献：
  名称：

  Steroid derivatives with an additional ring annulated to ring A and use of these derivatives for the preparation of meiosis regulating medicaments

  摘要：

  本发明涉及具有额外环并接到环A的药用活性类固醇衍生物，以及包含这些化合物的药物组合物，以及利用这些化合物制备药物的用途。更具体地，已经发现本发明中描述的类固醇可以用于调节减数分裂。

  公开号：

  EP1127890A1

文献信息

• [EN] STEROID DERIVATIVES WITH AN ADDITIONAL RING ANNULATED TO RING A AND USE OF THESE DERIVATIVES FOR THE PREPARATION OF MEIOSIS REGULATING MEDICAMENTS<br/>[FR] DERIVES DE STEROIDES A CYCLE ADDITIONNEL ANNELE AU CYCLE A, ET UTILISATION DE CES DERIVES POUR PREPARER DES MEDICAMENTS REGULANT LA MEIOSE
  申请人：SCHERING AG

  公开号：WO2001062771A1

  公开（公告）日：2001-08-30

  The present invention relates to pharmaceutically active steroid derivatives with an additional ring annulated to ring A, to pharmaceutical compositions comprising and to the use of these compounds for the preparation of medicaments. More particularly it has been found that the described steroids of the invention can be used for regulating meiosis.
• Steroid derivatives with an additional ring annulated to ring A and use of these derivatives for the preparation of meiosis regulating medicaments
  申请人：SCHERING AKTIENGESELLSCHAFT

  公开号：EP1127890A1

  公开（公告）日：2001-08-29

  The present invention relates to pharmaceutically active steroid derivatives with an additional ring annulated to ring A, to pharmaceutical compositions comprising and to the use of these compounds for the preparation of medicaments. More particularly it has been found that the described steroids of the invention can be used for regulating meiosis.

  本发明涉及具有额外环并接到环A的药用活性类固醇衍生物，以及包含这些化合物的药物组合物，以及利用这些化合物制备药物的用途。更具体地，已经发现本发明中描述的类固醇可以用于调节减数分裂。