1-(1-(2-hydroxynaphthalen-1-yl)ethyl)pyrrolidin-2-one | 1543021-71-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(1-(2-hydroxynaphthalen-1-yl)ethyl)pyrrolidin-2-one
• 英文别名: 1-[1-(2-Hydroxynaphthalen-1-yl)ethyl]pyrrolidin-2-one；1-[1-(2-hydroxynaphthalen-1-yl)ethyl]pyrrolidin-2-one
• CAS: 1543021-71-1
• 化学式: C₁₆H₁₇NO₂
• 分子量: 255.316
• InChiKey: JMNQCBKHQFDODL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-乙烯基吡咯烷酮 在 aluminum (III) chloride 作用下， 以 氯仿 为溶剂， 反应 24.0h， 生成 1-(1-(2-hydroxynaphthalen-1-yl)ethyl)pyrrolidin-2-one
  参考文献：
  名称：

  Synthesis of Dithiocarbamates by Markovnikov Addition Reaction in PEG and Their Application in Amidoalkylation of Naphthols and Indoles

  摘要：

  Synthesis of dithiocarbamates by the one-pot three-component Markovnikov addition reaction of an amine, carbon disulfide and an alkyl vinyl ether or N-vinylpyrrolidone is reported in polyethylene glycol (PEG) under a mild and green procedure with high yields and completely regiospecific. Also, the products were used as efficient starting materials for amidoalkylation of electron-rich arenes such as naphthols and indoles.

  DOI：

  10.5935/0103-5053.20150119

文献信息

• Friedel–Crafts alkylation of 2-naphthols with enamides and enethers induced by catalytic amount of triarylaminium salt
  作者：Congde Huo、Lisheng Kang、Xiaolan Xu、Xiaodong Jia、Xicun Wang、Yong Yuan、Haisheng Xie

  DOI：10.1016/j.tet.2013.12.067

  日期：2014.2

  A novel and efficient regioselective Friedel–Crafts alkylation reaction of 2-naphthols with electron-rich enamides or enethers initiated by catalytic amounts of stable radical cation triarylaminium salt has been developed. The processes occur under mild conditions.

  通过催化量的稳定的自由基阳离子三芳基铵盐引发的2-萘酚与富电子的酰胺或醚的新颖有效的区域选择性Friedel-Crafts烷基化反应已得到开发。该过程在温和的条件下发生。
• Synthesis of Dithiocarbamates by Markovnikov Addition Reaction in PEG and Their Application in Amidoalkylation of Naphthols and Indoles
  作者：Azim Ziyaei Halimehjani、Arefeh Dadras、Meraj Ramezani、Elham V. Shamiri、Seyyed E. Hooshmand、Mohammad M. Hashemi

  DOI：10.5935/0103-5053.20150119

  日期：——

  Synthesis of dithiocarbamates by the one-pot three-component Markovnikov addition reaction of an amine, carbon disulfide and an alkyl vinyl ether or N-vinylpyrrolidone is reported in polyethylene glycol (PEG) under a mild and green procedure with high yields and completely regiospecific. Also, the products were used as efficient starting materials for amidoalkylation of electron-rich arenes such as naphthols and indoles.