3β-cholesteryl 12'-(R)-hydroxyoctadec-9'-(Z)-enoate | 40445-74-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3β-cholesteryl 12'-(R)-hydroxyoctadec-9'-(Z)-enoate
• 英文别名: [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] (Z,12R)-12-hydroxyoctadec-9-enoate
• CAS: 40445-74-7
• 化学式: C₄₅H₇₈O₃
• 分子量: 667.113
• InChiKey: SECMIXNUMRJSQR-MQAHTPPESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.1
• 重原子数：
  48
• 可旋转键数：
  22
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  蓖麻油酸 、 胆固醇 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 以75%的产率得到3β-cholesteryl 12'-(R)-hydroxyoctadec-9'-(Z)-enoate
  参考文献：
  名称：

  胆固醇的新型脂肪酸类似物的合成与表征：体外抗菌活性

  摘要：

  在本研究中，我们合成，表征和检查了胆固醇脂肪酸类似物的抗菌活性。使用IR，1 H NMR，13 C NMR和质谱数据对合成的化合物进行表征，并通过对细菌的革兰氏阳性，革兰氏阴性菌株以及真菌菌株稍加修饰的圆盘扩散测定法测试其抗菌活性。还确定了所有合成化合物的最小抑菌浓度（MIC）。化合物7 – 14对细菌和四种真菌菌株均显示出抑制作用。测试化合物的体外抗菌活性表明，化合物10和13是优异的抗菌剂，其中化合物13和14是八种合成化合物中的优异抗真菌剂。

  DOI：

  10.1016/j.ejmech.2009.12.052

文献信息

• Hair cosmetic compositions comprising an amide derivative
  申请人：Kao Corporation

  公开号：EP0845256A2

  公开（公告）日：1998-06-03

  Described is a hair cosmetic composition comprising an amide compound having a melting point of 0 to 50oC. The hair cosmetic composition according to the present invention can impart the hair with suppleness, improve the touch feeling and bring about spilt hair preventive effects. Concerning the touch feeling, in particular, the composition can impart the hair with natural feeling, more specifically, with moisturized feeling, finger passing ease, styling ease, luster and not greasy but good oily feeling, whereby the hair with healthy, moisturized and young impression can be obtained.

  本发明描述了一种头发化妆品组合物，该组合物包含一种酰胺化合物，其熔点为 0 至 50 摄氏度。根据本发明的头发化妆品组合物可以赋予头发柔顺感，改善触感，并带来防止头发散落的效果。特别是在触感方面，本发明的组合物可以赋予头发自然的触感，更具体地说，具有滋润感、易于手指穿过、易于造型、有光泽和不油腻但油性好的感觉，从而可以获得健康、滋润和年轻的头发。
• LIPOSOME FOR DELIVERY TO POSTERIOR SEGMENT OF EYE AND PHARMACEUTICAL COMPOSITION FOR DISEASE IN POSTERIOR SEGMENT OF EYE
  申请人：Nagoya Industrial Science Research Institute

  公开号：EP2255788A1

  公开（公告）日：2010-12-01

  The invention provides a liposome for delivery to the posterior segment of the eye, comprising (A) a phospholipid, (B) a charged substance, and/or (C) a membrane-reinforcing substance; the liposome having a rigidity that provides the liposome with cell membrane permeability, and having a mean particle diameter of 1 µm or less; and a pharmaceutical composition for a disease in the posterior segment of an eye, comprising a drug encapsulated in the liposome. The liposome is delivered to the posterior segment of the eye by instillation, and is non-cytotoxic; and the pharmaceutical composition for a disease in the posterior segment of the eye comprises the liposome.

  本发明提供了一种用于向眼球后段给药的脂质体，包括(A)磷脂、(B)带电物质和/或(C)膜强化物质；脂质体具有一定的硬度，使脂质体具有细胞膜渗透性，且平均颗粒直径为1微米或更小；以及一种治疗眼球后段疾病的药物组合物，包括封装在脂质体中的药物。脂质体通过灌注输送到眼球后段，无细胞毒性；治疗眼球后段疾病的药物组合物包括脂质体。
• OIL-IN-WATER COSMETIC
  申请人：Shiseido Co., Ltd.

  公开号：EP2359801A1

  公开（公告）日：2011-08-24

  The present invention provides an oil-in-water cosmetic excellent in emulsion stability. The oil-in-water cosmetic includes (a) oil-droplet particles consisting of an oil component to be emulsified;(b) vesicle particles for stabilizing the oil-droplet particles; and (c) an aqueous phase containing water and a monohydric aliphatic alcohol having 1 to 4 carbon atoms. It is preferred that the vesicle particles are formed with an amphiphilic substance which spontaneously forms vesicle particles, and that they are localized on surfaces of the oil-droplet particles. It is preferred that the amphiphilic substance be a polyoxyethylenehydrogenated castor oil derivative represented by the following formula (1), whereinE=L+M+N+X+Y+Z, and that said E which represents the average addition mole number of ethylene oxide is 10 to 20.

  本发明提供了一种乳液稳定性极佳的水包油化妆品。水包油化妆品包括：（a）由待乳化的油成分组成的油滴颗粒；（b）用于稳定油滴颗粒的囊泡颗粒；以及（c）含有水和具有 1 至 4 个碳原子的一元脂肪醇的水相。囊泡颗粒最好是由自发形成囊泡颗粒的两亲性物质形成，并定位于油滴颗粒的表面。两亲性物质最好是由下式（1）表示的聚氧乙烯氢化蓖麻油衍生物，其中 E=L+M+N+X+Y+Z 表示环氧乙烷的平均添加摩尔数为 10 至 20。
• Oil-in-water emulsion type cosmetic preparation
  申请人：Gotou Naoki

  公开号：US20060067902A1

  公开（公告）日：2006-03-30

  The present invention relates to an oil-in-water emulsion type cosmetic preparation that can offer excellent skin feel (non-sticky feel and long-lasting moisturizing feel) and exhibit excellent long-term emulsion stability, containing (A) one or more members selected from the group consisting of ester compounds which are reaction products of erythritol and/or erythritol condensate with a fatty acid(s); polycondensates of erythritol and/or erythritol condensate, the above-mentioned ester compound(s) and a polycarboxylic acid(s); polycondensates of a fatty acid(s) with a polycondensate(s) of erythritol and/or erythritol condensate with a polycarboxylic acid(s); and polycondensates of erythritol and/or erythritol condensate, a fatty acid(s) and a polycarboxylic acid(s); (B) a nonionic surfactant and/or an ionic surfactant with an HLB of 10 or more; and (C) a water-base ingredient.

  本发明涉及一种水包油型乳液化妆品制剂，该制剂可提供极佳的肤感（无黏腻感和持久保湿感），并表现出极佳的长期乳液稳定性，其中含有 (A) 一种或多种选自以下组成的成员：酯类化合物，其为赤藓糖醇和/或赤藓糖醇缩合物与脂肪酸的反应产物；赤藓糖醇和/或赤藓糖醇缩合物、上述酯类化合物和聚羧酸的缩聚物； 脂肪酸与赤藓糖醇和/或赤藓糖醇缩合物与聚羧酸的缩聚物；(B) 非离子表面活性剂和/或 HLB 为 10 或以上的离子表面活性剂；以及 (C) 水基成分。
• LIPOPHILIC SOLID COSMETIC COMPOSITION COMPRISING ACIDIC DYE
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0742710A1

  公开（公告）日：1996-11-20