FSL-1 lipoprotein, synthetic | 322455-70-9

• 分子结构分类: 有机化合物 - 有机聚合物 - 多肽
• 英文名称: FSL-1 lipoprotein, synthetic
• 英文别名: (3S)-4-[(2S)-2-[[(2S)-6-amino-1-[[(2S)-1-[(2S)-2-[[(2S)-6-amino-1-[[(2S)-1-[[(1S)-1-carboxy-2-phenylethyl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxohexan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-[[2-[[(2R)-2-amino-3-[2,3-di(hexadecanoyloxy)propylsulfanyl]propanoyl]amino]acetyl]amino]-4-oxobutanoic acid
• CAS: 322455-70-9
• 化学式: C₈₄H₁₄₀N₁₄O₁₈S
• 分子量: 1666.2
• InChiKey: VJJLLNHELGKSNA-YWKNMTRCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  117
• 可旋转键数：
  69
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  524
• 氢给体数：
  14
• 氢受体数：
  23

文献信息

• Treatment of B cells with IL-21 and B cell activators induces Granzyme B production
  申请人：Weiner George

  公开号：US20070071717A1

  公开（公告）日：2007-03-29

  The present invention involves the combined use of IL-21 and TLR agonists such as CpG oligonucleotides in the treatment of B cell cancers and B cell-related immune pathologies such as autoimmune diseases. In addition, it is demonstrated that human B cells produce and secrete varying amounts of Granzyme B in response to IL-21 depending on their activation state, and at the same order of magnitude as those secreted by cytotoxic T lymphocytes. In CpG ODN-treated B-CLL cells, Granzyme B secretion in response to IL-21 can be cytotoxic.