carnitine hydrobromide | 92303-57-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: carnitine hydrobromide
• 英文别名: (3-Carboxy-2-hydroxypropyl)-trimethylazanium;bromide；(3-carboxy-2-hydroxypropyl)-trimethylazanium;bromide
• CAS: 92303-57-6
• 化学式: BrH*C₇H₁₅NO₃
• 分子量: 242.113
• InChiKey: WREGFMQRDKANCE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.23
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  60.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  aqueous trimethylamine 、 4-溴乙酰乙酸乙酯 、 铂 生成 carnitine hydrobromide 、 DL-肉碱盐酸盐
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Esters of acyl L-carnitines with gamma-hydroxybutyric acid and pharmaceutical compositions containing them for inhibiting neuronal degeneration and for the treatment of coma
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP0442850A1

  公开（公告）日：1991-08-21

  The esters of acyl L-carnitines with gamma-hydroxybutyric acid in the form of pharmacologically acceptable salts of formula (I) wherein X⁻ is the anion of a pharmacologically acceptable salt, e.g. chloride, bromide, orotate, acid aspartate, acid citrate, acid phosphate, acid fumarate, lactate, acid maleate, acid oxalate, acid sulfate and glucosephosphate or in the form of inner salts of formula (I′) wherein R is a straight or branched acyl group having from 2 to 5 carbon atoms, such as e.g. acetyl, propionyl, n-butyryl, isobutyryl and isovaleryl, are active in inhibiting neuronal degeneration (as it occurs in Alzheimer's senile dementia and Parkinson's disease) and in the treatment of coma.

  酰基 L-肉碱与γ-羟基丁酸的酯，其形式为药理学上可接受的式 (I) 盐 其中 X-是药理学上可接受的盐的阴离子，如氯化物、溴化物、乳清酸盐、酸天冬氨酸盐、酸柠檬酸盐、酸磷酸盐、酸富马酸盐、乳酸盐、酸马来酸盐、酸草酸盐、酸硫酸盐和葡萄糖磷酸盐，或以式（I′）内盐的形式存在 其中 R 是具有 2 至 5 个碳原子的直链或支链酰基，如乙酰基、丙酰基、正丁酰基、异丁酰基和异戊酰基等，它们在抑制神经元变性（如阿尔兹海默氏老年痴呆症和帕金森氏病中发生的变性）和治疗昏迷方面具有活性。
• Phthalidilidene derivatives of carnitine and alkanoylcarnitines and pharmaceutical compositions containing them
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP0488965A1

  公开（公告）日：1992-06-03

  (3-phtalidylidene) alkyl esters of carnitine and alkanoyl carnitines of general formula (I) wherein    Y is a C₁-C₅ alkylene group, unsubstituted or substituted with one or more lower C₁-C₄ alkyl groups;    R is hydrogen or C₂-C₆ alkanoyl;    R₁, R₂,R₃, and R₄, identical or different, are hydrogen, halogen C₁-C₈ alkoxy, C₁-C₄ lower alkyl, halogen-substituted lower alkyl, amino, alkyl-substituted amino wherein the alkyl group has 1 to 4 carbon atoms, nitro, cyano, C₁-C₄ alkanoylamino, or R₁ and R₂ taken together, R₂ and R₃ taken together or R₃ and R₄ taken together form a C₁-C₄ alkylenedioxy group, and X⁻ is the anion of a pharmacologically acceptable salt are potent PAF (plateletactivating factor) and acetyl-cholinesterase antagonists. Pharmaceutical compositions containing the compounds of formula (I) are useful for the therapeutical treatment of inflammatory and allergic conditions, particularly asthma, anaphylactic shock, as contraceptives and for the treatment of pre-senile and senile dementias (typically, Alzheimer's disease).

  (3-phtalidylene) 烷基肉碱酯和通式 (I) 的烷酰基肉碱 其中 Y 是 C₁-C₅ 亚烷基，未被取代或被一个或多个低级 C₁-C₄ 烷基取代； R 是氢或 C₂-C₆ 烷酰基； R₁、R₂、R₃ 和 R₄，相同或不同，是氢、卤素 C₁-C₈烷氧基、C₁-C₄低级烷基、卤素取代的低级烷基、氨基、烷基取代的氨基（其中烷基有 1 至 4 个碳原子）、硝基、氰基、C₁-C₄烷酰氨基、或 R₁ 和 R₂ 合在一起、R₂ 和 R₃ 合在一起或 R₃ 和 R₄ 合在一起形成 C₁-C₄ 烷基二氧基，且 X- 是药理学上可接受的盐的阴离子，是强效的 PAF（血小板活化因子）和乙酰胆碱酯酶拮抗剂。 含有式 (I) 化合物的药物组合物可用于治疗炎症和过敏性疾病，尤其是哮喘、过敏性休克，也可用作避孕药和治疗老年前期痴呆症和老年性痴呆症（通常是阿尔茨海默氏症）。
• Use of esters of acyl L-carnitines with gamma-hydroxybutyric acid for producing pharmaceutical compositions for the treatment of hepatopathies
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP0514357A1

  公开（公告）日：1992-11-19

  Esters of acyl L-carnitine with gamma-hydroxybutyric acid, both as pharmacologically acceptable salts of formula (1) and as inner salts of formula (1') wherein X⁻ is the anion of a pharmacologically acceptable acid and R is a straight or branched acyl group having from 2 to 5 carbon atoms, are used for producing pharmaceutical compositions effective for treating hepatopathies.

  酰基 L-肉碱与γ-羟基丁酸的酯，两者均为药理上可接受的式 (1) 盐 和式 (1') 的内盐 其中 X- 是药理学上可接受的酸的阴离子，R 是具有 2 至 5 个碳原子的直链或支链酰基，用于生产治疗肝病的药物组合物。
• Esters of L-carnitine and alkanoyl L-carnitines with glycolic acid or esters thereof and pharmaceutical compositions containing same for treating dermatoses
  申请人：AVANTGARDE S.p.A.

  公开号：EP0596838A2

  公开（公告）日：1994-05-11

  Ester of L-carnitine and alkanoyl L-carnitines with glycolic acid and esters thereof are disclosed, which are formulated into topically applicable pharmaceutical compositions for the treatment of dermatoses.

  本发明公开了左旋肉碱和烷酰左旋肉碱与乙醇酸的酯及其酯类，它们被配制成局部适用的药物组合物，用于治疗皮肤病。
• Use of phthalidyliden esters of carnitine and alkanoyl carnitines for the treatment of endotoxic shock
  申请人：Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.

  公开号：EP0706793A2

  公开（公告）日：1996-04-17

  The use of (3-phthalidyliden) alkyl esters of carnitine and alkanoyl carnitines for preparing pharmaceutical compositions suitable for treating endotoxic shock is disclosed.

  本发明公开了肉碱和烷酰肉碱的（3-酞酰基）烷基酯在制备适用于治疗内毒素休克的药物组合物中的用途。