2,6-bis(dimethylamino)purine | 27363-48-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2,6-bis(dimethylamino)purine
• 英文别名: tetra-N-methyl-7(9)H-purine-2,6-diamine；2,6-bis-(Dimethylamino)purin；2,6-Bis-(dimethylamino)purine；2-N,2-N,6-N,6-N-tetramethyl-7H-purine-2,6-diamine
• CAS: 27363-48-0
• 化学式: C₉H₁₄N₆
• 分子量: 206.25
• InChiKey: DISLZNJQOHAVHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  60.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  三乙胺 、 黄嘌呤 在 三氯氧磷 作用下， 生成 2,6-bis(dimethylamino)purine
  参考文献：
  名称：

  Purines. I. The Chlorination of Certain Purinones with Phosphorous Oxychloride in the Presence of Aliphatic Tertiary Amines¹

  摘要：

  DOI：

  10.1021/ja01134a047

文献信息

• PEPTIDE NUCLEIC ACID MONOMERS AND OLIGOMERS
  申请人：Ugisense AG

  公开号：US20170166900A1

  公开（公告）日：2017-06-15

  The invention relates to new peptide nucleic acid monomers and peptide nucleic acid oligomers comprising a dialkylamine side chain substituted with phosphonic acid ester group(s) or phosphonic acid group(s), and to the uses thereof.

  本发明涉及新的肽核酸单体和肽核酸寡聚物，包括具有磷酸酯基团或磷酸基团取代的二烷基胺侧链，以及其用途。
• The optimized microwave-assisted decomposition of formamides and its synthetic utility in the amination reactions of purines
  作者：Lucie Čechová、Petr Jansa、Michal Šála、Martin Dračínský、Antonín Holý、Zlatko Janeba

  DOI：10.1016/j.tet.2010.12.040

  日期：2011.2

  The microwave-assisted decomposition of DMF was thoroughly studied and the reaction conditions (temperature, solvent effect, and effect of additives, such as acids, bases, and salts) were optimized for its use in amination reactions. The applicability of this expedient methodology in purine chemistry and with various formamides is demonstrated. (C) 2010 Elsevier Ltd. All rights reserved.
• Purines. I. The Chlorination of Certain Purinones with Phosphorous Oxychloride in the Presence of Aliphatic Tertiary Amines¹
  作者：Roland K. Robins、Bert E. Christensen

  DOI：10.1021/ja01134a047

  日期：1952.7