N-(1-methyl-[4]piperidyl)-N-[2]thienylmethyl-aniline; hydrogentartrate | 2784-55-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(1-methyl-[4]piperidyl)-N-[2]thienylmethyl-aniline; hydrogentartrate
• 英文别名: N-(1-Methyl-[4]piperidyl)-N-[2]thienylmethyl-anilin; Hydrogentartrat；Sandostan；thenalidine tartrate；Thenalidintartrat；2,3-dihydroxybutanedioic acid;1-methyl-N-phenyl-N-(thiophen-2-ylmethyl)piperidin-4-amine
• CAS: 2784-55-6
• 化学式: C₄H₆O₆*C₁₇H₂₂N₂S
• 分子量: 436.529
• InChiKey: JNZAGODMPIMPAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.73
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  150
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• An otorhinological drug delivery device
  申请人：Schering Oy

  公开号：EP1438942A1

  公开（公告）日：2004-07-21

  The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elastomer composition selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Si-atoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof.

  本发明涉及一种包含至少一种药用活性剂的耳鼻喉给药装置。根据本发明，该装置包括一个包含所述至少一种药物活性剂的芯体，其中所述芯体由弹性体组合物制成，该弹性体组合物选自聚（二甲基硅氧烷）、硅氧烷基弹性体（包含连接到硅氧烷单元S原子上的3,3,3-三氟丙基）、硅氧烷基弹性体（包含聚（环氧烷）基团）及其混合物组成的组。
• Compositions and methods for the treatment of pain
  申请人：GM Pharmaceuticals, Inc.

  公开号：US10987365B2

  公开（公告）日：2021-04-27

  The claimed invention relates to compositions that may be in a form of a liquid, solid, gel, cream or gel capsule comprising an analgesic, and methods for administering these compositions for treatment of patients suffering from various forms of pain.

  本发明涉及可为液体、固体、凝胶、乳膏或凝胶胶囊形式的包含镇痛剂的组合物，以及使用这些组合物治疗各种形式疼痛患者的方法。
• Otorhinological delivery device
  申请人：Haapakumpu Timo

  公开号：US20060067982A1

  公开（公告）日：2006-03-30

  The invention relates to an otorhinological delivery device comprising at least one pharmaceutically active agent. According to the invention the device comprises a core comprising said at least one pharmaceutically active agent wherein said core is made of an elastomer composition selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Siatoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof, and a membrane encasing said core, said membrane being made of a same or a different elastomer composition than said core, said elastomer composition being selected from the group consisting of poly(dimethylsiloxane), a siloxane-based elastomer comprising 3,3,3-trifluoropropyl groups attached to the Siatoms of the siloxane units, a siloxane-based elastomer comprising poly(alkylene oxide) groups and mixtures thereof. The invention is characterized in that the pharmaceutically active agent is selected from the group comprising anti-allergic agents, anti-inflammatory agents, anti-fungicides, glucocorticoids and mixtures thereof.

  本发明涉及一种包含至少一种药用活性剂的耳鼻喉给药装置。根据本发明，该装置包括一个包含所述至少一种药物活性剂的核心，其中所述核心由弹性体组合物制成，该组合物选自聚（二甲基硅氧烷）、硅氧烷基弹性体（包含连接到硅氧烷单元硅原子上的 3,3,3-三氟丙基）、硅氧烷基弹性体（包含聚（环氧亚烷基）基团）及其混合物组成的组、以及包覆所述芯材的膜，所述膜由与所述芯材相同或不同的弹性体组合物制成，所述弹性体组合物选自聚二甲基硅氧烷、硅氧烷单元硅原子上附有 3,3,3-三氟丙基的硅氧烷基弹性体、聚环氧烷基硅氧烷基弹性体及其混合物组成的组。本发明的特征在于，药物活性剂选自抗过敏剂、抗炎剂、抗真菌剂、糖皮质激素及其混合物。
• PHARMACEUTICAL COMPOSITIONS INCLUDING AN ANTIHISTAMINE AND A STIMULANT AND USE THEREOF
  申请人：Pediamed Pharmaceuticals, Inc.

  公开号：EP1641446A1

  公开（公告）日：2006-04-05
• Pharmaceutical compositions including an antihistamine and a stimulant and method of use thereof
  申请人：PediaMed Pharmaceuticals, Inc.

  公开号：US20040259809A1

  公开（公告）日：2004-12-23

  The present invention provides pharmaceutical compositions including a sedating antihistamine and a stimulant, and methods of use thereof. The stimulant reduces the sedation caused by the antihistamine, thereby allowing potent, but sedating, antihistamines to be used effectively.